Office for Technology Licensing & Industry Collaboration Business Development Activities

1. Office for Technology Licensing & Industry CollaborationBusiness Development Activities Start-up efforts (15%) Market outreach (20%) Research agreements (25%) Inventor outreach /IP strategy (30%) Licensenegotiations (10%)

2. Benchmarking Tufts University Technology Transfer2005 Survey, Association of University Technology Managers (AUTM)

3. Benchmarking Tufts University Technology TransferAssociation of University Technology Managers (AUTM) Surveys Adjusted Gross Income* * Net of payments made to other institutions that report to AUTM

5. Tufts University Technology TransferLegal Expense Reimbursements

6. Tufts University’s Commitment to Developing Intellectual Property Portfolios

7. Tufts University Start-Up Companies Operational as of October 2006 (1 of 2)

8. Tufts University Start-Up Companies Operational as of October 2006 (2 of 2)

10. Tufts–New England Medical CenterStart-Up Companies Operational as of October 2006

11. Tufts–New England Medical Center

12. 900 802 Out-of-Pocket Capitalized 600 466 403 336 282 Millions of 2000 $ 300 121 0 Preclinical Clinical Total Out-of-Pocket (Cash Outlay) and Capitalized Cost per Approved Drug Source: DiMasi et al, J Health Economics 2003;22(2):151-185

13. Research Day on Drug Discovery and Development – September 27, 2006

14. Research Day on Drug Discovery and Development – September 27, 2006 Corporate and Investment Entities in Attendance • MPM Capital – Boston, MA • Novartis Pharmaceuticals – Cambridge, MA • Novocyte – MA • Paloma Pharmaceuticals, Inc. – Boston, MA • PhRMA – Washington, DC • Prism Venture Partners – Westwood, MA • Research Corporation Technologies – Cambridge, MA • Rishi Pharmaceuticals, Inc. – Newton, MA • Rutgers-Wellgen, Inc. – New Brunswick, NJ • SMC – Chelmsford, MA • Still River Funds – Waltham, MA Angel Healthcare Investors – Newton, MA Ascent Therapeutics, Inc. – Sherborn, MA Curis, Inc. – Cambridge, MA Clinquest, Inc. – Hudson, MA CytRx Corporation – Worcester, MA Fusionview LLC – Cambridge, MA Genzyme – Cambridge, MA HealthCare Ventures LLC – Cambridge, MA MDS Pharma Services - King of Prussia, PA Merck - Whitehouse Station, NJ Mizuho Trust & Banking Co. – Tokyo, Japan

15. Challenges and Strategies • Invest long term in early-stage technologies • Build robust pipeline through diversity of Tufts University and Tufts–New England Medical Center technologies • Involve inventors as stakeholders • Build relationships with investors and corporate partners

21. Research Funding ExpensesAUTM Licensing Survey, 2003

22. Invention Disclosures / $10MM in Total Research ExpensesAUTM Licensing Survey, 2003

23. New Patent Applications / $10MM in Total Research ExpensesAUTM Licensing Survey, 2003

24. Licensing Activity Ranked by New Licenses in 2003AUTM Licensing Survey, 2003

25. Total and New Licenses / $10MM in Research ExpensesAUTM Licensing Survey, 2003

26. 2003 Licensing Income AUTM Licensing Survey, 2003

27. Licensing Income/Program AgeAUTM Licensing Survey, 2003

28. Research Funding Related to Licensing AgreementsAUTM Licensing Survey, 2003