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Diuretics - Osmotic and carbonic anhydrase inhibitors

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  1. Diuretics - Osmotic and carbonic anhydrase inhibitors MOA AND SIDE EFFECTS 90-99

  2. CARBONIC ANHYDRASE INHIBITORS SITE OF ACTION PROXIMAL CONVULATED TUBULE MOA IN THE KIDNEY:Inhibit carbonic anhydrase enzyme in the renal tubules → decrease absorption of bicarbonate and sodium → diuresis IN THE EYE:Inhibit carbonic anhydrase enzyme in the eyes → decrease production of the aqueous humor → decrease intraocular pressure

  3. SIDE EFFECTS Metabolic acidosis Hypokalemia Hyperchloremia Neurological side effects, e.g., headache, seizures, mental status changes, paraesthesia Gastrointestinal side effects, e.g., altered sense of taste, nausea, vomiting and diarrhea

  4. OSMOTIC DIURETICS SITE OF ACTION 1.PCT 2.Descending limb of loop of henle 3.Collecting duct MOA =>Freely filtered into the tubules → increases osmolality of the tubular fluid → draws water into the tubules for excretion along with mannitol

  5. SIDE EFFECTS 1.Aggravate of fluid overload conditions 2.Dehydration 3.Hypotension 4.onfusion 5.Nausea 6.Vomiting

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