Exam 2 Review

1. Exam 2 Review  Kent Lin and McKenna Wilhelm

2. Lecture 9/23 Lecture Overview  • History  • Lipid components and asymmetry  • Bioactive lipid metabolites  • Membrane proteins  • Amino acids in the membrane  • Lipid modifications  • Subdomains (lipid rafts) 

9. Lecture 9/25 Lecture Overview  • Selective permeability  • Osmolarity and osmotic pressure  • Ionic gradients  • Electrical properties: resistance and capacitance  • Electrochemical equilibrium  • Environmental change  • GHK equation  • Intro to simulation 

12. Nice little website: https://www.medicine.mcgill.ca/physio/vlab/rmp/theory_RMP_n.htm

13. In General: Eion = (60 mV / z) * log ([ion]out / [ion]in) @ 30° 

14. Lecture 9/30 Lecture Overview • Review of cellular electricity  • Recording cellular electricity  • Theories about channel selectivity  • Channel structures and selectivity • Voltage-dependent gating  • Channel-lipid interactions  • Ligand-gated channels • Aquaporins and connexins 

24. The derivative of a function y = f(x) of a variable x is a measure of the rate at which the value y of the function changes with respect to the change of the variable x. It is called the derivative of f with respect to x.

26. Probability in respect to open or closed Time constant for when the system reaches equilibrium if starts out closed with consideration to a and b

30. Hyperinsulinemia in absence of KATP channel activity ? b-cell response to a fall in blood glucose in absence of KATP KATP channel isnot activated, insulin secretion is maintained, andblood glucose drops further…? Glucose Glut2 Glucose Blood Insulin ADP ATP + Ca 2+ KATP

31. Diabetes if KATP channels become overactive? If KATP channel isnot inhibited, insulin secretion remains turned off? Glucose Glucose Glut2 Glucose Blood Insulin ADP ATP 2+ Ca KATP

32. Membrane flux what is it governed by • How types of transporter affects flux of solutes • How transport is determined by membrane potential