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platelet-derived growth factor alpha polypeptide

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines.

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platelet-derived growth factor alpha polypeptide

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  1. pdgfa pdgfa Official Full Name Official Full Name platelet-derived growth factor alpha polypeptide Background Background The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene Synonyms Synonyms PDGFA; platelet-derived growth factor alpha polypeptide; PDGF1; PDGF-A; PDGF A-chain; platelet-derived growth factor alpha chain; Platelet- derived growth factor subunit A; PDGF subunit A; Platelet-derived growth factor A chain; PDGF-1; OTTHUMP00000199955; OTTHUMP00000199956; platelet-derived growth factor alpha isoform 2 preproprotein Recombinant Recombinant Proteins Proteins  Cell & Tissue Lysates Cell & Tissue Lysates Cat.# Cat.# Product name Product name Source (Host) Source (Host) Species Species Tag Tag Price Price PDGFA-514M Recombinant Mouse PDGFA Protein, His-tagged Yeast Mouse His +Inquiry PDGFA-563H Recombinant Human PDGFA Protein (Ser87-Thr211), His-tagged Yeast Human His +Inquiry PDGFA-923C Recombinant Canine PDGFA Protein (Ser87-Arg196), His-tagged Yeast Canine His +Inquiry

  2. Cat.# Cat.# Product name Product name Source (Host) Source (Host) Species Species Tag Tag Price Price PDGFA-940R Recombinant Rat PDGFA Protein (Ser87-Arg196), His-tagged Yeast Rat His +Inquiry PDGFA&PDGFB-17H Recombinant Human PDGF-AB E. coli Human N/A +Inquiry PDGFA-047H Recombinant Human PDGFA Protein HEK293 cells Human +Inquiry PDGFA-121H Recombinant Human PDGFA E. coli Human N/A +Inquiry PDGFA-1609H Recombinant Human PDGFA, GST-tagged E. coli Human GST +Inquiry PDGFA-174H Recombinant Human PDGFA protein, His/S-tagged E. coli Human His/S +Inquiry PDGFA-375H Recombinant Human Platelet-derived Growth Factor AA HEK293 Human N/A +Inquiry PDGFA-523H Recombinant Human PDGFA HEK293 Human +Inquiry PDGFA-54H Recombinant Human PDGFA, His-tagged E. coli Human His +Inquiry PDGFA-56H Recombinant Human PDGFAA Yeast Human N/A +Inquiry PDGFA-57H Recombinant Human PDGFA protein E. coli Human N/A +Inquiry

  3. Cat.# Cat.# Product name Product name Source (Host) Source (Host) Species Species Tag Tag Price Price Pdgfa-048M Recombinant Mouse Pdgfa Protein HEK293 cells Mouse +Inquiry PDGFA-12567M Recombinant Mouse PDGFA Protein Mammalian Cells Mouse His +Inquiry Pdgfa-175M Recombinant Mouse Pdgfa protein, His/S-tagged E. coli Mouse His/S +Inquiry Pdgfa-298M Recombinant Mouse Platelet Derived Growth Factor AA E. coli Mouse N/A +Inquiry Pdgfa-304M Recombinant Mouse Pdgfa E. coli Mouse N/A +Inquiry Pdgfa-564M Recombinant Mouse Pdgfa protein, His-tagged E. coli Mouse His +Inquiry Pdgfa&Pdgfb-216R Recombinant Rat Pdgfa&Pdgfb E. coli Rat +Inquiry Pdgfa-176R Recombinant Rat Pdgfa protein, His/S-tagged E. coli Rat His/S +Inquiry Pdgfa-215R Recombinant Rat Pdgfa E. coli Rat +Inquiry Pdgfa-2732R Recombinant Rat Pdgfa protein, His & T7-tagged E. coli Rat His/T7 +Inquiry PDGFA-4337R Recombinant Rat PDGFA Protein Mammalian Cells Rat His +Inquiry

  4. Cat.# Cat.# Product name Product name Source (Host) Source (Host) Species Species Tag Tag Price Price PDGFA-1044C Recombinant Canine PDGFA Protein, Fc-tagged HEK293 Canine Fc +Inquiry PDGFA-5879C Recombinant Chicken PDGFA Mammalian Cells Chicken His +Inquiry PDGFA-101H Recombinant Human PDGFA E. coli Human +Inquiry Involved Pathway Pdgfa involved in several pathways and played different roles in them. We selected most pathways Pdgfa participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pdgfa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Name Pathway Related Protein Pathway Related Protein MAPK signaling pathway CACNA1BA; TGFB1A; PPM1A; CACNB3; TGFBR2; MKNK2A; GNA12; CDC42; RASGRF2B; ATF4B1 Ras signaling pathway VEGFB; GNB3; KIT; PLA2G12A; RASAL3; RASGRP3; HGF; RGL1; GNG3; RELA Rap signaling pathway PRKD2; LCP2; RAF1; GNAS; MRAS; CALM2; FGF7; FGF16; RAC3; GRIN2B Cytokine-cytokine receptor interaction LEP; CCL18; CSF1RA; IFNAR1; OSTN; CX3CL1; IL5; LOC100033925; CCR9A; CXCL8 Phospholipase D signaling pathway TSC2; RALGDS; PLCB1; PDGFA; AKT1; PPAP2C; PIP5K1C; HRAS; KRAS; PLCB3 PIK-Akt signaling pathway CCND1; IL2RB; FGFR1; ITGB6; RPS6KB2; PGF; FGF7; HRAS; Kitl; FGF2 Focal adhesion TNK2; CCND1; GSK3B; PTENA; CDC42L2; ITGB1A; COL27A1; RAC3B; AKT2; AASS Gap junction

  5. PLCB4; TUBB6; TUBA3E; TUBA8L4; PDGFC; GUCY1A3; DRD2L; GNA15.4; GNAQ; CX43 Regulation of actin cytoskeleton MLCK2; SSH1; INSB; CDC42L2; MSNB; PAK3; ITGB1A; MRAS; FGF6B; CYFIP2 HTLV-I infection TNFRSF13C; WNT7B; DVL3; WNT5A; STAT5A; NFATC2; ETS1; LTA; TSPO; CD3G Pathways in cancer FZD6; SLC2A1; FGF14; TGFBR2; GNGT1; Fzd4; LAMB2; APC; LAMA2; FGF16 Transcriptional misregulation in cancer SIX1; H3F3C; WNT16; MLLT3; CD14; TCF3; PBX1; TP53; TSPAN7; CCNT1 MicroRNAs in cancer WNT3A; GRB2; ERBB2; MMP16; BCL2L2; TGFB2; CD44; PRKCG; SPRY2; STMN1 Glioma PLCG1; CAMK2B; TRP53; CALML3; SHC2; CAMK2A; PIK3R1; SHC1; CALML5; SHC4 Prostate cancer CPN1; PIK3R5; EP300; INSRR; CCND1; NRAS; PIK3R1; KRAS; PDGFB; NDRG1 Melanoma AKT1; MITF; FGF9; FGF11; TRP53; IGF1R; FGF21; MET; MAPK3; MDM2 Choline metabolism in cancer SLC22A2; EGF; SLC44A1; RPS6KB2; DGKQ; PPAP2B; LYPLA1; GPCPD1; MAPK10; WAS Protein Function Pdgfa has several biochemical functions, for example, collagen binding, growth factor activity, platelet-derived growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pdgfa itself. We selected most functions Pdgfa had, and list some proteins which have the same functions with Pdgfa. You can find most of the proteins on our site. Function Function Related Protein Related Protein Function Function collagen binding Related Protein Related Protein SRGN; ASPN; SERPINH2; MRC2; ANTXR1; MMP13; CTSB; ITGA9; SERPINH1B; NID2 Function Function growth factor activity Related Protein Related Protein LIF; IGF1; LEP; FGF3; REG1A; PDGFAA; FGF10B; OGN; MSTNB; NENF Function Function platelet-derived growth factor binding Related Protein Related Protein PDGFRB; PDGFRA; COL2A1; COL5A1; COL1A1; PDGFB; Pdgfa&Pdgfb; COL3A1; COL6A1; COL1A2 Function Function platelet-derived growth factor receptor binding

  6. Related Protein Related Protein TYMP; LYN; PTEN; PDGFRA; Pdgfa&Pdgfb; PDGFC; PTPRJ; PDGFA; PDGFRB; PDGFD Function Function protein binding Related Prot Related Protein ein HCFC1; MAP3K11; USP25; APPL2; GNMT; C2orf50; ADAM15; PRDX3; RNF41; SYTL2 Function Function protein heterodimerization activity Related Protein Related Protein DRD1A; TBX15; ZHX3; CLCN3; UBXN6; IRAK3; ITGB1; HIST1H4J; XBP1; TAF12 Function Function protein homodimerization activity Related Protein Related Protein FLRT3; KIAA0947; UPK1A; ABCD1; TENM3; MBL1; DMRTA2; NPR3; HMGCL; SPPL3 Interacting Protein Pdgfa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pdgfa here. Most of them are supplied by our site. Hope this information will be useful for your research of Pdgfa. PDGFRA; PDGFRB; PDGFB Pdgfa Related Articles Miro, L; Perez-Bosque, A; et al. Vasopressin regulation of epithelial colonic proliferation and permeability is mediated by pericryptal platelet-derived growth factor A. EXPERIMENTAL PHYSIOLOGY 99:1325-1334(2014). Miller, JD; Benjamin, JT; et al. Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 298:L637-L645(2010).

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