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Introductory portion

Physical pharmaceutics -II

Chandrashekhar3
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Introductory portion

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  1. CHHATRAPATI SHIVAJI COLLAGEOF PHARMACY, DEORI PRESENTED BY :- PAVAN BISEN AND GROUP (B. PHARMACY 2ND YEAR) TOPIC :- COLLOIDAL DISPERSION AND IT’S CLASSIFICATION GUIDED BY :- CHANDRASHEKHAR BADWAIK SIR

  2. PHYSICAL PHARMACEUTICS Physical pharmaceutics is the branch of pharmacy that integrates the knowledge of physics and chemistry to the study of pharmacy and pertain them to pharmaceutical dosage form development. • Solution :- A homogenous mixture of two or more substances. • Solute :- The component of a solution that is preset in lesser amount than the solvent. • Solvent:- The component of the solution that is present in greater amount and the substances in which the solute is dissolves. • Dispersed phase:- Substances that is dispersed within another. • Continuous phase:- Substances that extends throughout the system and surrounded the dispersed phase.

  3. COLLOIDAL DISPERSION Colloidal dispersion is a system in which two substances in which one substance is distributed among the another. • Solute- Dispersed phase DISPERESED • Solvent- Continuous phase SYSTEM

  4. CLASSIFICATION ACCORDING TO PARTICLE SIZE 1. Molecular Dispersion:- • These are the system in which particle size of dispersed phase is less than 1nm. • They are visible in electron microscope and they pass through ultrafilter and semipermeable membrane and particle do not settle down they undergo rapid diffusion. 2. Colloidal Dispersion:- • These are the system in which particles size of dispersed phase is 1nm to 0.5nm. • They cannot be seen by ordinary microscope but it can be seen by electron microscope. • This particle pass through filter paper but do not pass through semipermeable membrane. • They can be separated by both centrifugal and ultrafiltration.

  5. 3. Coarse Dispersion:- • In this system the particle size of dispersed phase is more than 0.5nm. • These particle are visible under ordinary microscope. • Dose not pass through filter paper and semipermeable membrane. • Particle settle down under gravity. Example. Emulsions and suspensions.

  6. SHAPE AND SIZE OF COLLOIDAL DISPERSIONS Particle Size:- • Particle lying in the colloidal size having surface area and it compared to large particles. • Platinum is effective as catalyst if any in colloidal form due to their large surface area. • Color of colloidal dispersion is related to size of particles i.e. red gold. • Red gold taken the blue colour when particles size is increases. Red gold solution blue color (when particle size increases)

  7. Gold Number The gold number is defined as minimum weight in milligram of protective colloids (dry weight of dispersed phase) required to prevent a colour from red to violet in 10ml of gold solution on addition to 1ml of 10% solution of sodium chloride. Lower the gold number, grater the protective action.

  8. Particle shape:- Shape of colloidal particle depend on; • Method by which they are prepared. • Type of interaction they have with dispersion medium. • Colloidal particles exist in cubical spherical, spiral thread, cylindrical disc and rod shaped. • Spherical particles of gold is dispersion medium show red color. • When gold disc like particles given blue color.

  9. Fig; Some shapes that can be assumed by colloidal particles: a)Spherical and globular, b)Short rods and prolate ellipsoids, c)Oblate ellipsoids and flakes, d)Long rods and threads, e)Loosely colloid threads, f)Branched threads.

  10. THANK YOU…….!

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