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1. www.wisepowder.com wise12@wisepowder.com Nootropics powder Wisepowder has a full range of raw materials of Nootropics powder , and has a total quality management system. Nootropics Nootropics powder or smart drugs are well-known compounds or supplements that enhance the cognitive performance. They work by increasing the mental function such as memory, creativity, motivation, and attention. Recent researches were focused on establishing a new potential nootropics derived from synthetic and natural products. The influence of nootropics in the brain has been studied widely. The nootropics affects the brain performances through number of mechanisms or pathways, for example, dopaminergic pathway. Previous researches have reported the influence of nootropics on treating memory disorders, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Those disorders are observed to impair the same pathways of the nootropics. Thus, recent established nootropics are designed sensitively and effectively towards the pathways. Natural nootropics such as Ginkgo biloba have been widely studied to support the beneficial nootropics benefits. Nootropics Classify  There are two different nootropics: synthetic, a lab created compound such as Piracetam powder, and notable natural and herbal nootropics, such as Ginkgo biloba and Panax quinquefolius (American Ginseng). Nootropics are proven in boosting the brain function while at the same time making the brain healthier.  Mechanisms of Action of Nootropics  Best Nootropics powder decreases malondialdehyde levels in brain, increases levels of antioxidant molecules such as; glutathione and superoxide dismutase. v  Interaction with dopamine-D2, serotonergic and GABAB receptors. v 1 / 5

2. www.wisepowder.com wise12@wisepowder.com  Reduction of MAO-A and plasma corticosterone levels. v  Reduces the concentration of noradrenaline and decrease turnover of central monoamines. v  Inhibition of acetylcholinesterase activity in brain. v  Increases content of lipids and phospholipids in brain. v  Protects neurons against glutamate-induced toxicity. v  Modulation of NMDA receptor activity. v  Free-radical-scavenging activity; reduces H2O2- induced cytotoxicity and DNA damage. Nootropics Applications: ·Boost Learning and Memory: Learning is the process of acquiring new knowledge or modifying existing knowledge, while memory is the ability of the brain to encode, store, and retrieve information when needed. Both learning and memory are vital to enjoying experiences, planning future actions, and maintaining a high quality of life. ·Improve Focus and Attention: Focus and attention are the ability to concentrate one’s mind on a single task while ignoring extraneous environmental stimuli. There are several different aspects of attention, and they underlie many other cognitive functions. ·Improve Your Brain Energy: 2 / 5

3. www.wisepowder.com wise12@wisepowder.com The brain consumes approximately 20 percent of the body’s energy, and brain energy has been associated with overall brain health. Without sufficient energy, all cognitive processing of the brain will be slowed down. ·May Lead to a Better Mood Mood encompasses a wide variety of states of mind, including anxiety and depression. A poor mood has been shown to impact brain energy, stress resistance, and brain circulation. ·Increase Your Stress Resilience Stress clearly impacts mental performance and overall well-being. While stress management should be a key part of any program to improve cognitive function, some nootropics powder may also help. ·Offer Neuroprotection While many people use these substances for an instant brain boost, the long-term neuroprotective benefits of nootropics should not be overlooked. Some research suggests that aspects of age-related cognitive decline can begin in healthy, educated adults even while they’re in their 20s and 30s. In other words, it’s never too early to start taking care of your brain—and nootropics Powders could play a role. How to Use Nootropics? If you’re going to start experimenting with nootropic supplements Powder, you will need to make a couple of small investments to get started. Most high-quality best nootropics are sold in their pure form as nootropics bulk powders. Naturally, you may be wondering how you’re supposed to measure and nootropic powder how to take. Since most of these compounds are present in nature, you can add such plant-based foods to your diet. Besides, you can use vegan and organic supplements to your diet to get their full potential benefits. Or, you can add them in powder form to smoothies, tea, or juices. Some people are allergic to a few substances; For this reason, you need to listen to your body and your doctor and use these nootropic 3 / 5

4. www.wisepowder.com wise12@wisepowder.com supplements accordingly. No supplement can outdo the harmful effects of poor lifestyle choices that don’t support your brain health. Hence, you need to make positive changes inyour lifestyle to gain the most advantages of these smart drugs. Are Nootropics Safe? Determining nootropic safety is more complex than it may seem. Unlike pharmaceutical drugs, nootropic supplements do not have to undergo clinical trials demonstrating their safety before being sold. All the process of nootropics production may affect the nootropic safety. From nootropics powder source to nootropics drugs final use. Nootropics powder is the most important ingredient of nootropics supplements, nootropics powder manufacturer is the direct nootropics powder source. A good nootropics powder factory must have manufacturing facilities designed with safety as the top priority. Other factors affect Nootropics safe are include: (1) Research-backed safety The best way to verify a nootropic’s safety is with human clinical trials. (2) Advanced nootropic forms When nootropic ingredients(high nootropics powder) are presented in higher-quality forms, their safety may improve (3) Careful formulation (4) Clean delivery What good are safe nootropics if the capsules that carry them are bad for you? In nootropic supplements, we sometimes see manufacturers using capsules, additives and questionable ingredient choices that have been associated with potential health risks. (4) Clean delivery (5)Take nootropics correctly Buy Nootropics? 4 / 5

5. www.wisepowder.com wise12@wisepowder.com If you want to buy nootropics, the first thinking maybe is “Are nootropics safe?” . It is difficult to give a straight yes or no answer. Because there are far too many variables that can affect nootropic safety, from ingredient to ingredient and brand to brand. Before buy nootropics powder, it is better do more search, from nootropics powder source to delivery. Reference: 1. Lanni C., Lenzken S. C., Pascale A., et al. Cognition enhancers between treating and doping the mind. Pharmacological Research. 2008;5 7(3):196–213. doi: 10.1016/j.phrs.2008.02.004. 2. Dartigues J.-F., Carcaillon L., Helmer C., Lechevallier N., Lafuma A., Khoshnood B. Vasodilators and nootropics as predictors of dementia and mortality in the PAQUID cohort. Journal of the American Geriatrics Society. 2007;55(3):395–399. doi: 10.1111/j.1532-5415.2007.0108 4.x. 3. Kessler J., Thiel A., Karbe H., Heiss W. D. Piracetam improves activated blood flow and facilitates rehabilitation of poststroke aphasic pati ents. Stroke. 2000;31(9):2112–2116. doi: 10.1161/01.STR.31.9.2112. 4. Raichle M. E., Mintun M. A. Brain work and brain imaging. Annual Review of Neuroscience. 2006;29:449–476. doi: 10.1146/annurev.neu ro.29.051605.112819. 5. Kumar V., Khanna V. K., Seth P. K., Singh P. N., Bhattacharya S. K. Brain neurotransmitter receptor binding and nootropic studies on India n Hypericum perforatum Linn. Phytotherapy Research. 2002;16(3):210–216. doi: 10.1002r.1101. 6. Nootropic drugs: Methylphenidate, modafinil and piracetam – Population use trends, occurrence in the environment, ecotoxicity and re moval methods – A review. Wilms W, Woźniak-Karczewska M, Corvini PF, Chrzanowski Ł. Chemosphere. 2019 Jun 4;233:771-785. doi: 10.10 16/j.chemosphere.2019.06.016. Review.PMID: 31200137 5 / 5