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Tibsovo Targeted Therapy for Acute Myeloid Leukemia (AML)

According to Tibsovo manufacturer, the IDH1 enzyme`s mutated form typically produces a metabolite, 2-hydroxyglutarate (2-HG), which is likely to play a significant role in the development and progression of AML, gliomas, and other cancers.

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Tibsovo Targeted Therapy for Acute Myeloid Leukemia (AML)

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  1. Tibsovo: Targeted Therapy for Acute Myeloid Leukemia (AML) Acute Myeloid Leukemia (AML) is a type of blood cancer that affects the bone marrow and blood cells. It is characterized by the rapid growth of abnormal white blood cells, preventing the production of healthy blood cells. AML is a challenging disease to treat and requires innovative therapies.

  2. Introducing Tibsovo • Tibsovo (generic name: ivosidenib) is a targeted therapy approved by the FDA for the treatment of relapsed or refractory AML with an IDH1 mutation. • It is a small molecule inhibitor that specifically targets and inhibits mutant isocitrate dehydrogenase 1 (IDH1) enzymes. • IDH1 mutations are found in approximately 20% of AML patients.

  3. Mechanism of Action • IDH1 mutations produce a metabolite called 2-hydroxyglutarate (2-HG), which disrupts normal cellular processes. • Tibsovo binds to mutant IDH1 enzymes, blocking their activity and reducing the levels of 2-HG. • By reducing 2-HG levels, Tibsovo helps restore normal cellular differentiation and inhibits leukemia cell growth.

  4. Clinical Efficacy • The approval of Tibsovo was based on a phase 1 clinical trial that showed promising results. • In the study, patients with relapsed or refractory AML and an IDH1 mutation achieved an overall response rate of 32.8%. • The median duration of response was 8.2 months.

  5. Safety Profile • The most common adverse reactions reported with Tibsovo include fatigue, nausea, diarrhea, joint pain, and decreased appetite. • It is important to note that Tibsovo can cause differentiation syndrome, a potentially life-threatening condition.

  6. Conclusion • Tibsovo represents a significant advancement in the treatment of relapsed or refractory AML with an IDH1 mutation. • Targeted therapies like Tibsovo offer a personalized approach by specifically addressing the underlying genetic alterations driving the disease. • Ongoing research and clinical trials continue to explore the full potential of Tibsovo in AML and other IDH1-mutated cancers.

  7. FAQ’s 1. Is Tibsovo Tablet Available In India? Tibsovo is a pharmaceutical prescription medication that can be only dispensed against a valid medical prescription. THE INDIAN PHARMA can facilitate the import of Tibsovo to all locations after fulfilling the legal requirement (if applicable). Please contact us via +919310090915 | TOLL-FREE: 1800-889-1064 or write us at info@theindianpharma.com to buy Tibsovo tablets online in India. 2. Can I get Tibsovo even if I am not based in India? THE INDIAN PHARMA (TIP) helps patients in accessing or importing Tibsovoivosidenib, not approved in their home country against the valid prescription and in conformity with the local laws and regulations of their respective country. 3. Where can I get Tibsovo Tablets at the best price? In order to get the best price of Tibsovo in India and other countries, always buy this medication from a Pharmaceutical Wholesaler Company which is GDP certified. Noida-based The Indian Pharma can offer the best price for Tibsovo Tablets.

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