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Lenangio 5mg,10mg,25mg is belongs to anticancer medication which contains Lenalidomide as an active substance which belongs to thalidomide analogue. It is used to the disease condition by combining with dexamethasone. It consist of some other pharmacological activities like immuno modulatory & anti-angiogenesis.
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LENANGIO - 5MG,10MG,25MG DESCRIPTION : Lenangio 5mg,10mg,25mg is belongs to anticancer medication which contains Lenalidomide as an active substance which belongs to thalidomide analogue.Lenangio 5mg,10mg,25mg is used to the disease condition by combining with dexamethasone.Lenangio 5mg,10mg,25mg consist of some other pharmacological activities like immuno modulatory & anti- angiogenesis.Lenangio 5mg,10mg,25mg is a prescription drug that can only use under the supervision of medical oncologist. INDICATION The indications of Lenangio 5mg,10mg,25mg are; Lenangio combination with dexamethasone is indicated to treat the patients suffered from multiple myeloma Lenangio is indicated for the patients having transfusion- dependent anemia because of intermediate 1 risk myelodysplastic syndrome along with deletion 5q cytogenetic abnormality without or without addition cytogenetic abnormalities Lenangio is used to treat the patients with mantle cell lymphoma in which its used whose the disease was relapsed or progressed after two before treatment, especially the disease not response with the bortezomib therapy.
LENANGIO - 5MG,10MG,25MG MECHANISM Lenangio 5mg,10mg,25mg involves in the prudence of tumor and factor alpha arrangement, that reinforcement the T- cells and leads to lessening plasma levels of cytokines vascular endothelial growth factor and fundamental fibroblast growth factor. Lenangio 5mg,10mg,25mg is moreover engaged with the stave off angiogenesis. Lenalidomide is furthermore authorize G1 cell cycle capture and apoptosis of ruinous cells. PHARMACOKINETICS Absorption: Absorbed rapidly with peak plasma concentration is between 0.625 and 1.5 hrs. combining with food will not change the prolong of absorption but dose decrease in Cmax. Distribution: Bounding of plasma protein is 30% Metabolism: Mainly metabolized in two metabolites is hydroxy-lenalidomide and N-acetyl-lenalidomide.
Excretion: Primarily eliminated in renal route and the dose excreted via urine 90% and feces 4% and half-life is 3hrs DRUG INTERACTION Interaction of Lenangio 5mg,10mg,25mg with digoxin leads to increased concentration of digoxin causes increased risk of adverse effects related to digoxin. Interaction of Lenangio 5mg,10mg,25mg with Erythropoietic agents, cause to produced rises in risk of thrombosis. Discuss with the patients prior to starting this combination treatment. Interaction of Lenangio 5mg,10mg,25mg with warfarin, will produce increased exposure of hemorrhage disorders. check the INR value & prothrombin time. CONTRAINDICATION When pregnancy period the drug is contraindicated The patients are contraindicated to hypersensitivity reaction and the Lenangio 5mg,10mg,25mg component. OVER DOSAGE Over dosage of Lenangio 5mg,10mg,25mg will cause neutropenia & thrombocytopenia as mainly common side effects. Give the patient general supportive treatment. check the blood cells counts regularly during the treatment. MISSED DOSE The missed dose of Lenangio 5mg,10mg,25mg should be avoided. If missed dose
founded, then patients should be consulting with doctor specialized in oncologist Regulate the usual dosing schedule. SIDE EFFECTS Second primary malignancies Hepatotoxicity , Hypersensitivity reactions, Thyroid dysfunction, Fetal toxicity, Hematological toxicity, Tumor lysis syndrome, Tumor flare reactions, Increase of mortality rate. Common side effects; Diabetes mellitus, Rash, Insomnia, Depression, Deep vein thrombosis, Myocardial infraction, Renal failure, Squamous cell carcinoma, Basal cell carcinoma, Fatigue, Asthenia, Pyrexia, Pain, Diarrhea, Dyspepsia, Bone pain, Neck pain, Respiratory infections, UTI, Influenza, Sepsis, Headache, Anemia, Loss of appetite, Hypokalemia, Hyperglycemia, Hypocalcaemia, Dehydration, Gout. WARNING The some of the common life-threatening condition like : Venous & arterial thromboembolism Blood clotting effects Embryo fetal damage Hypersensitivity reactions Hematological disorders For all these conditions, some supportive measures should be used and provide safety measures. CONTACTS Phone : +91- 9987711567 Email: applepharmaceutical@gmail.com
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