Champions of Health Spotlight On Leaders Shaping Germany's Healthcare

1. April Issue 04 2024 Trends, Challenges and Opportuni?es The Future of Corporate Healthcare Champions of Health: Spotlight on Leaders Shaping Germany's Healthcare Transforma?onal and Emo?onal Competence Healthcare Leadership in the Digital Age Dr. Cornelius Glismann CEO CorporateHealth Dr. Dr. Cornelius Cornelius Glismann Leading Tech-Driven Transforma?on in Corporate Health Preven?on

4. Editor’s Note

5. Sculpting a Healthier Future f or Germany ermany has long been admired for G ranking among the best in the world. It stands as a global leader in medical innovation and healthcare delivery. At the forefront of this excellence are the brilliant minds and dedicated professionals who tirelessly strive to enhance patient care and innovate novel treatments and technologies. leading profound changes that are modernizing healthcare delivery, accelerating medical breakthroughs, and improving the health and well-being of people across Germany. its high-quality and universal healthcare system, consistently As the global population continues aging and the prevalence of chronic diseases rises, the need for accessible, affordable, and effective healthcare has never been greater. The champions featured in this edition are rising to meet these daunting challenges head-on through pioneering research, groundbreaking treatments, digital health solutions, and progressive policies and regulations. However, the nation’s healthcare system is not stagnant – it is continuously evolving thanks to the innovative leaders working tirelessly to improve patient outcomes, drive efficiencies, and embrace the latest advancements in medical science and technology. Their stories showcase the depth of expertise, passion for improving lives, and spirit of innovation that is driving Germany’s healthcare industry forward. We hope this window into their impactful work inspires others to join them in creating a healthier future for all. In this exclusive issue, ‘Champions of Health: Spotlight on Leaders Shaping Germany’s Healthcare,’ we feature some of the country’s most influential healthcare visionaries across various sectors. From forward-thinking physicians and researchers to health tech entrepreneurs and policymakers, these inspiring individuals are Immerse yourself into an enlightening read ahead! Natalie May Natalie May - Natalie May

6. 08 Dr. Cornelius Glismann Leading Tech-Driven Transformation in Corporate Health Prevention Cover Story

7. Profiles 20 Daniel Vitt Pioneering Biotech Leadership 30 Wolfgang Ries Driving Change in Spinal Care Through Innovation and Expertise Articles 26 Trends, Challenges and Opportunities The Future of Corporate Healthcare 36 Transformational and Emotional Competence Healthcare Leadership in the Digital Age

8. L E A D E R S EUR Health Editor-in-Chief Thanh Truong Managing Editor Pearl Shaw Executive Editor Natalie May Visualiser David King Art & Design Head Samuel Martinez Co-designer Paul Belin Art & Picture Editor Grace Brown Business Development Manager Emily Jones Business Development Executives Anna Smith, Jack Miller Marketing Manager Bill Thompson Sales Executives Mike, Carl, Lisa Technical Consultants David, Robert Assistant Technical Head Joseph Taylor Technical Head Jacob Smile Assistant Digital Marketing Manager Daniel Jones Digital Marketing Manager Alina Sege SME-SMO Executive Gemson Research Analyst Eric Smith Circulation Manager James Carter sales@eurohealthleaders.com APRIL, 2024 Contact Us: Insights Success Media and Technology Pvt. Ltd. Survey No.133/134, Brand Square, Office No. 512, Kunjir Chowk, Pimple Saudagar, Pune, Maharashtra 411027. Phone - India: 7410033802, 8956487823 Email: info@eurohealthleaders.com For Subscription: www.eurohealthleaders.com https://twitter.com/eurohealthleaders Insights Success Media Tech LLC 555 Metro Place North, Suite 100, Dublin, OH 43017, United States Phone - +1614-602-4132 Email: info@eurohealthleaders.com For Subscription: www.eurohealthleaders.com Follow us on : www.facebook.com/eurohealthleaders/ We are also available on : Copyright © 2024 Insights Success Media and Technology Pvt. Ltd., All rights reserved. The content and images used in this magazine should not be reproduced or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from Insights success. Reprint rights remain solely with Insights Success Media and Technology Pvt. Ltd. Euro Health Leaders is powered by Insights Success Media and Technology Pvt. Ltd.

9. CHAMPIONS OF HEALTH: SPOTLIGHT ON LEADERS SHAPING GERMANY'S HEALTHCARE Featuring Person Company Brief Boris Pasche is a distinguished leader with over 30 years of experience in cancer medicine and research. Boris Pasche Co-founder TheraBionic therabionic.de Dr. Cornelius Glismann is a visionary leader driving the transformation of corporate healthcare through the integration of advanced technologies and personalized solutions. CorporateHealth corporatehealth-ag.com Dr. Cornelius Glismann CEO Daniel Vitt is committed to innovative therapies for chronic conditions and is shaping the future of healthcare. Daniel Vitt CEO & President Immunic Therapeutics imux.com Tino Galgon, an experienced professional, brings strategic vision and leadership to the forefront, driving innovation and excellence in the industry. Lyocontract lyocontract.de Tino Galgon Managing Director Wolfgang Ries's expertise drives innovation in minimally invasive spinal surgery, elevating patient care to new heights. Joimax joimax.com Wolfgang Ries CEO & Founder

10. Dr. Dr. Cornelius Cornelius Glismann Leading Tech-Driven Transforma?on in Corporate Health Preven?on I always had a high affinity for the IT sec?on and got more involved in the development of the latest technology for preventa?ve medical diagnos?cs.

11. Cov Story Dr. Cornelius Glismann CEO CorporateHealth

12. Champions of Health: Spotlight On Leaders Shaping Germany's Healthcare T reshaping the way we approach medical care. As the worlds of health and technology converge, the need for adept leaders who can navigate this dynamic intersection becomes imperative. This exclusive feature spotlights one such figure – Dr. Cornelius Glismann, the CEO of CorporateHealth. CorporateHealth he landscape of healthcare and preventative medicine is undergoing a profound transformation, with the integration of advanced technologies Failures, a project for the FDA that laid the foundation for his expertise in health diagnostics and the complex relationship between healthcare and technology. Following his academic pursuits, Dr. Glismann dived into the professional field with Beckman Coulter, a diagnostic company. His role in a specialized think tank focused on developing next-generation large laboratory haematology diagnostics for a global program deepened his insights into diagnostics within a specific domain. Subsequently, he returned to Europe, his home country, after spending a significant period in the United States. With over two decades of experience in national and international healthcare business development, Dr. Glismann has engraved a lasting mark in the industry. His journey is marked by senior positions and influential consultations with leading global entities such as CIGNA, Fresenius/VAMED, Asklepios, Deloitte, and Beckman Coulter. Armed with an M.Sc. in Industrial Engineering from the Technical University of Aachen, Germany, and a Ph.D. in Biomedical Engineering from the University of Miami, USA, he possesses the necessary blend of technical expertise and strategic vision. Reflecting on his experience in both countries, Dr. Glismann noted, "I spent a large amount in the US, which also shaped my view on healthcare because the US is much more focused on health than on patient repair." Contrasting the German healthcare system, known for its efficiency in patient care during illness, he observed a broader focus on health itself (and disease prevention) in the US. Upon his return to Europe, Dr. Glismann joined Deloitte Consulting, specializing in life sciences. In this capacity, he consulted with global and mid-sized companies, offering strategic insights into the intersection of healthcare and technology. He revealed, "My focus was mainly on health diagnostics but also using the latest technological innovations. So, throughout my whole development, I always had a high affinity for the IT section and got more involved in the development of the latest technology for preventative medical diagnostics." In our era health prevention is increasingly becoming synonymous with personalized solutions, and Dr. Glismann's vision is right on point. His commitment to a 'segment of one' approach, even within large corporate environments like Porsche, Henkel, or Nestlé, sets CorporateHealth apart in the german industry of corporate health prevention and medical diagnostics for employees. Recently, CorporateHealth initiated the implementation of state-of-the-art AI-driven solutions that bear the potential to redefine diverse diagnostic processes. Dr. Glismann emphasized the power of these technologies, explaining how a simple scan of an individual's face can yield a comprehensive health status within a mere 30 seconds. This breakthrough not only expedites the diagnostic process in the future but also provides individuals with personalized health insights, avoiding traditional lengthy doctor visits. Quest for Innovative Prevention Medicine Dr. Glismann's journey was ignited by his experiences, particularly in the United States. Witnessing the strides made in preventive medicine and cutting-edge technology, he recognized the contrast with the state of preventative Medicine in Europe. He envisioned an efficient health promotion program based on best-practice preventative medical diagnostics that could extend beyond traditional boundaries, allowing individuals to manage their health seamlessly, even from the comfort of their homes. He emphasized, "So it's managing your health rather than just diagnosing it." The central aspect lies in empowering individuals with the knowledge and technology needed to understand and easily take actions, in an independent and convenient manner, regarding their health in daily life. Our editorial team had the privilege of interacting with Dr. Glismann, unveiling the strategic decisions and innovative approaches. Venturing in Healthcare, Preventative Medicine and Technology Dr. Glismann started his career in the United States by securing a scholarship for biomedical engineering at the University of Miami. His early contributions included establishing the National Healthcare Test Center for Heart Practical healthcare management, according to Dr. Glismann, centers on enabling individuals to monitor critical parameters daily.

13. Dr Glismann at the Sports, Medicine and Health Summit 2023 in Hamburg This proactive approach allows for early intervention or consultation, preventing the need for deeper medical interventions; with the former mitigating health-related deterioration in the affected person and the latter entailing significant savings for the healthcare systems. Establishing CorporateHealth During his tenure at Deloitte, Dr. Glismann gained invaluable insights into the strategic development and modelling of various healthcare businesses and diagnostics. Following his professional period at Deloitte, he assumed the role of director for one of Germany's largest local hospital chains. Under his leadership, the hospital underwent a transformative journey, transitioning into a private entity. This endeavour involved significant structural changes and analytical processes, providing him with a profound understanding of healthcare provisioning. Dr. Glismann's vision is anchored in the proac?ve promo?on of health, striving to create a paradigm shi? from trea?ng diseases to preserving and enhancing well-being. His next venture led him to the Fresenius Group, where he played a pivotal role in developing and designing healthcare centres.

15. Notably, one of these centres focused on prevention, sparking Dr. Glismann's interest in scaling up preventive medicine initiatives. He recognized a gap in Germany's healthcare system, which predominantly concentrated on patient support and treatment rather than preventive measures. Driven by this insight, Dr. Glismann founded his first company—a five-star health center in Hamburg focused on preventative medicine and health promotion rather than patient repair. With a sprawling 1000 square meters of top-notch diagnostics, the center housed two leading professors from the University of Munich. Together, they developed the center from scratch, catering to private patients and corporate managers. Building on this success, Dr. Glismann joined forces with new partners and established CorporateHealth in 2012. Starting with the vision to create a prevention medicine company, CorporateHealth has since evolved into a corporate diagnostics entity. His strategic approach involved rolling out a stepwise model that has now expanded to 25 cooperating health centres across Germany. These centres are strategically contracted and integrated under an IT platform, forming a virtual chain entirely dedicated to offer health promotion programs and medical screenings for corporations, senior executives and employees. Dr. Glismann envisions CorporateHealth transforming into a comprehensive disease prevention and medical diagnostics company, transcending its initial role as a corporate diagnostics and health promotion provider for its corporate customers and patients. Pioneering Preventive Medicine and Remote Diagnostics CorporateHealth, today a frontrunner in the field of preventive medicine for corporates, Innova?on in a box: The IntelliGI® pa?ent box for performing colon capsule endoscopy procedures

16. CorporateHealth Interna?onal Headquarter in Inverness (Scotland), United Kingdom has ventured into the world of E-health technologies. Dr. Glismann proudly highlights the transformation of an innovative IT platform that not only manages electronic health records but also seamlessly integrates E-Health and AI-based solutions from top providers in the market. their home. In this easy and reliable procedure they can scan their personal risk-level without the need for sedation or hospitalization. This technology, is especially transformative for remote areas like islands in Scotland, providing patients with challenging access to healthcare. Dr. Glismann emphasizes that this specific field focuses on early diagnostics through remote tele-diagnostics, catering to patients who benefit from remote access to healthcare. With the click of a button, individuals can now schedule appointments, access E-Health, and run AI-based solutions from the comfort of their homes. Dr. Glismann emphasizes, "We have initiated the process to soon be able to offer the full width of totally remote, hybrid, or life diagnostics, basically head to toe." This comprehensive approach allows individuals to track various health parameters, from heart health to stress levels, using smartphone technology, with the results seamlessly recorded in their electronic health records. These records can be shared with physicians for remote diagnostics or utilized for in-person life checks. CorporateHealth's commitment extends internationally, with a focus on health IT and preventive diagnostics. In 2015, Dr. Glismann, in collaboration with a partner from New York, founded CorporateHealth International. Headquartered in Denmark, the company pioneered tele- remote diagnostics, initially in regions in Denmark and later expanding to the UK and the US. We have ini?ated the process to soon be able to offer the full width of totally remote, hybrid or life diagnos?cs, basically head to toe. He explains the revolutionary and minimally-invasive "capsule endoscopy", which enables patients to undergo comprehensive colon cancer screenings from the comfort of

17. Fostering Connections Dr. Glismann actively participates in various healthcare forums, such as the Health Captain's Club, an international gathering of healthcare leaders. Additionally, he is engaged in national healthcare communities, maintaining close connections to understand the dynamics within the ecosystem at different levels. Driven by his passion for cutting-edge technologies, Dr. Glismann remains closely tied to developments in AI, E- Health, and telehealth. His involvement in these networks not only keeps him current with the latest advancements but also shapes the next steps in the development of CorporateHealth's vision. Building upon a robust platform that incorporates electronic records and appointment booking systems, CorporateHealth takes a proactive approach. They integrate the latest solutions from the market securely, ensuring the incorporation of state-of-the-art diagnostic tools. Dr. Glismann emphasizes the integration of advancements like AI-driven applications, particularly those emerging through smartphones. Leadership Anchored in Trust With his experience as a leader of various organizations, Dr. Glismann displays a leadership philosophy built on the bedrock of trust. According to him, trust is not just a guiding principle; it forms the very essence of his approach to running these organizations. Sustainable Health Prevention Solutions Considering the emerging innovations and prospective changes in the health promotion landscape in Germany, Dr. Cornelius Glismann identifies several critical factors, with health-IT standing out as a prominent catalyst for change. Equally important is the element of building confidence and trust among CorporateHealth´s stakeholders, such as cooperation partners, clients and users, with a particular emphasis on GDPR compliance, a factor highly esteemed in Germany due to the country's historical context. Trust becomes the cornerstone of effective leadership in a modern work landscape where employees operate remotely, spanning different countries and continents. Dr. Glismann underscores the significance of trust, confidence, and empowerment, especially as many of his team members work from home or in diverse locations like Asia, Spain, the UK, and the US. Dr. Glismann highlights the importance of sustainability, emphasizing solutions that save resources by eliminating the need for extensive travel, doctor visits, laboratories, and blood tests. However, he notes that the effectiveness of these solutions hinges on widespread trust and adaptation by the population. The acceptance of these methods is crucial for their adoption to yield positive results. He states, "I believe in having highly empowered employees that are passionate and whom I can trust. These employees will in return provide me with their trust because they are passionate, intrinsically motivated and engaged in their work." This reciprocal trust forms the cornerstone of a corporate culture where employees feel motivated and empowered to contribute their best. Dr. Glismann places considerable value on the conviction and dedication of his team members, relying on their passion and commitment to drive initiatives forward. This collaborative and trust-based approach not only reinforces the team's cohesion but also empowers individuals to excel in their roles. He underscores the concept of acceptance preceding adaptation, stressing that even if a product or solution is well-suited for an industry or country, it must gain acceptance, especially if trust is a factor hindering adoption.

18. Together on the front line: Dr Glismann and CorporateHealth Business Director Franziska Saller To establish and earn trust, CorporateHealth leverages strong partnerships with renowned medical centres from universities, ensuring the highest quality of medical services, whether delivered in person or through digital platforms. Industry partnerships with trusted names like IBM, Porsche, and Henkel further reinforce the reliability and safety of the technology, which is certified for GDPR compliance. contribute to building trust among the people, ultimately ensuring the successful integration and acceptance of innovative solutions in preventative medicine and health diagnostics. Future-Forward Health Dr. Glismann firmly believes in the transformative impact of early detection and preventive medicine, asserting that it makes a significant difference in people's lives. His philosophy centers on keeping individuals healthy, ensuring they have the Highest Level of Care (HLC), thus optimizing the quality and value of their lifespan. Beyond technology, CorporateHealth places emphasis on personal connections and communication. Dr. Glismann notes the importance of being available around the clock, offering advice, and ensuring that a human touch is maintained. This human-centric approach, combined with innovative technology, aims to bridge the gap between cutting-edge solutions and the personal nature of health promotion services. The essence of this approach lies in proactively supporting health, emphasizing the importance of early detection to prevent the onset and progression of diseases. Dr. Glismann sees this as a means to enhance customers' quality of life and a pathway to a more efficient and effective healthcare system. Dr. Glismann emphasizes the role of physicians, not just IT experts, as leaders in driving technology at CorporateHealth. Collaborative partnerships, credibility, and a deep understanding of patients and the human body In terms of efficiency, Dr. Glismann emphasizes the cost- effectiveness of preventive measures. Investing €1.00 in

19. prevention, he notes, can potentially save 10 to 100 times the cost that might be incurred in later stages of intervention and treatment. This economic efficiency aligns with the broader goal of delivering value to customers/patients while ensuring a sustainable and resource-efficient healthcare model. Dr. Glismann's vision is anchored in the proactive promotion of health, striving to create a paradigm shift from treating diseases to preserving and enhancing well-being. By focusing on early detection and preventive measures, CorporateHealth aims to not only contribute to the quality of life for individuals but also to revolutionize the efficiency and effectiveness of healthcare delivery. In Germany, CorporateHealth has established collaborations with leading centres in preventive diagnostics, renowned for their expertise in treating athletes. These partnerships include institutions such as the University of Heidelberg, Charity in Berlin, and the University of Munich, recognized for their roles in overseeing the health of Olympic athletes. Dr. Glismann actively engages with leaders in Scotland and Denmark, contributing to the continuous enhancement of program quality. Dr. Glismann's Guide to Thriving in Corporate Health Promotion Dr. Glismann shares valuable advice for aspiring leaders venturing into the field of corporate health promotion and medical services in prevention medicine. He emphasizes the importance of being curious and open-minded, considering the rapid evolution occurring in this sector. However, he compares this need for curiosity with the necessity for patience, emphasizing the conservative nature of the healthcare industry in Germany and its slow yet steady cycles. CorporateHealth is actively involved in comprehensive studies analyzing the outcomes of remote diagnostics provided. The company actively supports research trials through various partnerships, encompassing both private-public and university-public collaborations. It is not standalone but integral to a preventive healthcare community ecosystem. The interconnection of various healthcare sections, departments, and companies forms a collective effort to derive insights that contribute to individual well-being and corporate performance. Dr. Glismann underscores the long-term commitment required in this industry, distinguishing it from more fast- paced consumer-centric industries. He stresses that success in medical health promotion and all related sectors comes from understanding and embracing the enduring nature of the field. Highlighting these unique challenges of medical businesses, Dr. Glismann describes it as a complex yet fascinating system. The complexity spans from the details of the human body to the broader societal aspects, including financing and politics. According to him, the layers of complexity create a captivating environment for those who are fascinated by challenges. Dr. Glismann acknowledges the continuous advancements in AI, health promotion and telehealth. These innovations, he believes, contribute to improving overall health outcomes and addressing issues such as mental health in the workplace. He points out that the slow development in the field offers a distinct advantage – the ability to learn from other sectors and adapt those learnings to their own business. This adaptability and a genuine fascination for the complexities and challenges inherent in medical services make it the right field for those who want to make a meaningful difference.

21. “ The role of a leader in healthcare is to create an environment where people feel empowered to provide the best possible care to patients. - Rana Awdish

22. Daniel Vitt CEO and President Immunic Therapeutics Daniel Vitt Pioneering Biotech Leadership April 2024 www.eurohealthleaders.com 20

23. Champions of Health: Spotlight On Leaders Shaping Germany's Healthcare,,,,,,,, B chemistry and a passion for computational modeling, Dr. Vitt co-founded 4SC AG, a pioneering biotech firm. His journey continued with the establishment of Immunic Therapeutics, where as CEO and President, he leads a mission to develop innovative therapies for chronic inflammatory and autoimmune conditions. Through creative approaches and unwavering dedication to patient welfare, Dr. Vitt is shaping the future of biotechnology, offering new avenues of treatment and hope for those in need. iotechnology is at the forefront of transformative healthcare advancements, and pioneering it is Daniel Vitt, Ph.D. With a background steeped in OUR FOCUS IS AND HAS ALWAYS BEEN ON THE PATIENTS. AND PATIENTS DESERVE TO BENEFIT FROM SCIENTIFIC ADVANCEMENTS – WHICH ARE NATURALLY TIED TO COMMERCIAL SUCCESS. Let’s dive into the detailed interview to explore the transformative journey of Daniel Vitt, shaping the future of biotechnology with passion and resilience! Daniel, can you share with our readers a bit about your professional background and what inspired you to pursue a career in the biotechnology industry? Munich. I joined Immunic in January 2017 as CEO. Searching for access to public markets, we completed a reverse takeover transaction with the US company Vital Therapies, following which we became public on NASDAQ with headquarters in New York in 2019. Since then, I have been serving as Chief Executive Officer, President and Director of Immunic. In addition to my core role at Immunic, I am currently a member of the advisory board of a venture capital fund of Bayern Kapital GmbH. On top of this, I also co-founded Brauhaus Germering GmbH, a local Bavarian specialty brewery as a kind of escalated hoppy hobby. Well, this started pretty unspectacular. I studied chemistry in Siegen and Würzburg in Germany where I graduated focusing on quantum-chemical calculations of organic reactions. I liked these computer simulations very much – and still do – and this drove my interest towards the potential to use computers for simulating chemistry and designing new molecules. Therefore, I received my Ph.D. from the Institute of Organic Chemistry at the University of Würzburg with my doctoral thesis focusing on the molecular design of small molecule therapeutics. Starting from my Ph.D. work, I wanted to translate some of these interesting concepts on adaptive computer modeling into a professional setup and thus, I founded 4SC AG together with three colleagues, where we developed a leading in silico screening technology – today, you would call this an AI technology. 4SC became a publicly traded biotech company and I was responsible for technology and research in the role of the Chief Scientific Officer (CSO) and Chief Development Officer (CDO). While there, we successfully transitioned the company from a technology play into an advanced therapeutic development company with several clinical-stage product candidates in the pipeline and brought the company public on Frankfurt Stock Exchange in 2005. Looking back, I think that two things inspired me most: the use of computer simulations for design purposes and the possibility to develop new therapeutics which may finally end up in a pharmacy, offering patients with severe diseases new hope. Could you elaborate on the mission and vision of Immunic Therapeutics? What sets it apart from other companies in the biotechnology sector? We founded Immunic with the mission to develop a pipeline of next generation selective oral therapies focused on offering patients with chronic inflammatory and autoimmune diseases new and clinically meaningful treatment options. We have built an advanced, diversified pipeline of clinical development candidates, ranging from preclinical to phase 3 development across different therapeutic areas and indications in immunology. In 2016, together with three colleagues, we took the opportunity to buy out the immunology assets from 4SC, who narrowed their development pipeline focusing on an oncology pivotal study. So, we founded Immunic in April 2024 www.eurohealthleaders.com 21

24. 381 assets. IMU-856 is a pretty cool new approach to treating gastrointestinal disorders, aiming to regenerate the gut wall and barrier function by a new innovative targeted mechanism. We have already demonstrated clinical proof- of-concept for the molecule in celiac disease and are currently evaluating its further development path, including options in celiac disease, but also, for example, IBD or short bowel syndrome. IMU-381 is a development candidate with improved overall properties to specifically address the needs of gastrointestinal diseases. Could you discuss a key milestone or achievement during your tenure at Immunic that you are particularly proud of, and how it reflects your leadership style? I am convinced that good science and entrepreneurial spirit pave the way to success in our industry. The biggest challenge in biotech, however, is financing drug development. Looking back, it was a smart move to reverse merge with Vital Therapies in 2019 to become listed on NASDAQ – this gave us access to the capital markets and to the US investor base. Meanwhile, we were able to advance the development of our lead molecule vidofludimus calcium into clinical phase 3 in relapsing multiple sclerosis – and we also were able to demonstrate that our drug has a very unique mode of action which could change the life of millions of people suffering from MS. And I think we are on the right track to achieve our mission. In particular, with our late-stage clinical program in multiple sclerosis, our vidofludimus calcium asset, we were already able to show clear separation from existing, approved MS drugs with regards to safety, tolerability and efficacy, specifically mentioning neuroprotective effects, which no other drug has shown so far. We think vidofludimus calcium has the potential to be a unique treatment option targeted to the complex biology of MS, differentiated by its combined neuroprotective, anti- inflammatory, and antiviral effects. We hope that many patients with this serious autoimmune disease and its devastating consequences for their daily life will be able to benefit from the treatment in the not too far away future. What are the most significant challenges and opportunities facing the biotechnology industry today, and how is Immunic positioned to address them under your leadership? On top of this, we have a diversified earlier stage development pipeline, including our IMU-856 and IMU- I think that the financing of biotech is still by far the biggest challenge, and this needs intelligent and creative www.eurohealthleaders.com April 2024 22

25. Insights for Asping aders I believe in two key success factors: passion and resilience. Without passion, it is hard to reach any goal and without resilience, you may fail even before you start the journey. Resilience also covers an important aspect in our industry: if you are convinced and you have sufficient data and a strong scientific rationale, you should focus on the goal and not let yourself be frightened too much. However, one should keep a certain level of self- reflection – personally and professionally: Am I the ghost rider – are the other 1000 coming against me? - Daniel Vitt April 2024 23

26. does not come with the typical safety and tolerability concerns of patients. approaches by leaders to be solved. At Immunic, we always followed an adaptive approach and tried to build a portfolio of development programs that allows us some flexibility and independent efforts on financing, including dilutive and non-dilutive financing. Could you share a glimpse into the future of Immunic Therapeutics under your guidance, highlighting any upcoming projects or initiatives that our readers should look out for? The second biggest challenge from my point of view is the changing environment, including an aging population and political headwinds, such as the Inflation Reduction Act (IRA). We all need to stand together and focus on messaging to the public how important fair pricing of new treatments for unmet medical needs is, because this is the only way to finance breakthroughs in the healthcare space. Our key focus at the moment and the upcoming milestone we are most excited about is the readout of our phase 2 CALLIPER trial of vidofludimus calcium in progressive MS, which is expected in April 2025. If this data set continues to show a neuroprotective effect of the drug, we may be able to position vidofludimus calcium as the first oral treatment option for advanced Secondary Progressive MS (SPMS) – an indication with a particularly high unmet medical need within the MS space. How do you approach promoting innovation and driving growth within Immunic Therapeutics, ensuring a balance between scientific advancement and commercial success? In addition, we eagerly await the readout of our two phase 3 ENSURE trials of vidofludimus calcium in relapsing MS, both expected in 2026. Considering the promising clinical activity observed thus far, along with vidofludimus calcium's established safety and tolerability profile, we believe that the ENSURE program will enable a straightforward path toward potential regulatory approval. For every biotech company, this is the one key milestone to achieve, and I hope that we will see this not too far from now. Our focus is and has always been on the patients. And patients deserve to benefit from scientific advancements – which are naturally tied to commercial success. At Immunic, we start with the question “How can we improve the patient’s life?” and “What innovations can help us to be better with our approaches?” One example is our lead product vidofludimus calcium: offering patients a potential neuroprotective treatment could be a major breakthrough in the treatment landscape and change the life of many patients around the world in a sustainable way, while offering a treatment option that April 2024 www.eurohealthleaders.com 24

28. May 2024 www.eurohealthleaders.com 26

29. Trends, Challenges and Opportuni?es The Future of Corporate Corporate HEALTHCARE T changing workforce demographics, and evolving regulatory environments. As businesses strive to attract and retain top talent while managing rising healthcare costs, the way they approach employee health and well-being is evolving rapidly. he corporate healthcare landscape is undergoing a significant transformation, driven by a confluence of factors such as technological advancements, In this article, we explore the key trends, challenges and opportunities shaping the future of corporate healthcare. Trends: 1. Embracing Digital Health Solutions: The rapid proliferation of digital health technologies, such as telemedicine, mobile health apps, and wearable devices, is revolutionizing the way healthcare is delivered within corporate settings. These technologies offer convenience, cost-effectiveness, and real-time monitoring capabilities, enabling employees to access care more readily and employers to better manage healthcare expenses. 2. Focus on Preventive Care and Wellness: Recognizing the long-term benefits and cost savings associated with preventive care, many corporations are shifting their focus toward comprehensive wellness programs. These initiatives aim to promote healthy lifestyles, improve employee engagement, and reduce the risk of chronic conditions, ultimately leading to a healthier, more productive workforce. April 2024 www.eurohealthleaders.com 27

30. 3. Personalized Healthcare: With the advent of precision medicine and advanced data analytics, corporate healthcare is moving towards a more personalized approach. By leveraging employee health data, employers can tailor wellness programs, preventive screenings, and treatment plans to meet the unique needs of their workforce, leading to better health outcomes and cost optimization. Opportunities: 1. Leveraging Partnerships and Collaborations: Collaborating with healthcare providers, insurers, and technology companies can unlock new opportunities for corporations to enhance their healthcare offerings. By leveraging the expertise and resources of these partners, employers can gain access to cutting-edge solutions, streamline processes, and provide comprehensive care to their employees. 4. Workplace Mental Health Support: Mental health issues have become a growing concern in the corporate world, with stress, burnout, and anxiety taking a toll on employee well-being and productivity. As a result, companies are increasingly recognizing the importance of providing comprehensive mental health support, including employee assistance programs, counseling services, and mental health awareness initiatives. 2. Integrating Workforce Analytics: By harnessing the power of workforce analytics, corporations can gain valuable insights into employee health trends, risk factors, and the effectiveness of their healthcare programs. These insights can inform data-driven decision-making, allowing employers to optimize their strategies and allocate resources more effectively. Challenges: 1. Rising Healthcare Costs: Despite efforts to control expenses, healthcare costs continue to rise, straining corporate budgets and posing a significant challenge for employers. Balancing the need to provide comprehensive healthcare coverage while managing costs remains a delicate equilibrium for many organizations. 3. Promoting Corporate Wellness Cultures: Creating a culture of wellness within the organization can have far- reaching benefits beyond just healthcare cost savings. A healthy workforce is often more engaged, productive, and resilient, contributing to overall organizational success. Employers have the opportunity to foster a positive work environment that prioritizes employee well-being. 2. Data Privacy and Security Concerns: As digital health technologies become more prevalent, concerns around data privacy and security have emerged. Employers must navigate complex regulations and implement robust data protection measures to safeguard sensitive employee health information while still leveraging the benefits of these technologies. 4. Exploring Innovative Benefit Models: As the healthcare landscape evolves, employers can explore innovative benefit models that better align with their workforce needs and organizational goals. This could include adopting value-based healthcare models, exploring alternative care delivery methods, or implementing consumer-driven health plans. 3. Employee Engagement and Adoption: Implementing effective corporate healthcare programs requires active employee engagement and adoption. Overcoming barriers such as lack of awareness, resistance to change, and cultural norms can be challenging, necessitating thoughtful communication strategies and incentives to encourage participation. Conclusion A complex interplay of trends, challenges and opportunities shapes the future of corporate healthcare. By staying abreast of these developments and proactively addressing the challenges, corporations can position themselves to provide comprehensive, cost-effective, and innovative healthcare solutions that support the well-being of their employees and drive organizational success. 4. Managing a Multigenerational Workforce: With multiple generations in the workforce, corporate healthcare programs must cater to diverse needs and preferences. Tailoring programs to address the unique health concerns and communication styles of different age groups can be a complex undertaking for employers. - Natalie May April 2024 www.eurohealthleaders.com 28

32. Wolfgang Ries CEO & Founder joimax® April 2024 www.eurohealthleaders.com 30

33. Champions of Health: Spotlight on Leaders Shaping Germany's Healthcare Wolfgang Driving Change in Spinal Care Through Innovation and Expertise its excellence, marked by world-class medical infrastructure, stringent standards, and a steadfast Ries ermany boasts a healthcare sector distinguished by G dedication to patient welfare. With a robust healthcare system emphasizing accessibility, quality, and innovation, Germany serves as a cornerstone in shaping the future of global healthcare. continuously followed this path. I started joimax in 2001 in the basement and garage of my house together with my wife Irmgard. Before founding joimax , I worked for 9 years in various positions in sales, product and marketing management, was VP Business Development Europe at the Baxter CardioVascular Group, now Edwards LifeScience. I was Managing Director of the Franco-German company Saphir Medical for 2 years and held during my 3 years as a consultant the position of VP Marketing & Business Development at HydroCision Inc, Andover, MA. ® ® Wolfgang Ries, the CEO and Founder of joimax , emerges as a prominent figure within this dynamic healthcare environment. Through his entrepreneurial drive and visionary leadership, Ries has not only navigated but also significantly influenced the German healthcare landscape. As the driving force behind joimax , he has leveraged Germany’s healthcare expertise to propel endoscopic minimally invasive spinal surgery to unprecedented levels of success. ® What inspired you to focus on endoscopic minimally invasive spinal surgery within the healthcare industry? ® The human spine is the very sensitive but also strongest structure of the musculoskeletal system and one of its most complex organs. In this edition of ‘Champions of Health: Spotlight on Leaders Shaping Germany’s Healthcare,’ we delve into Ries’ extraordinary journey, his pioneering contributions, and his steadfast commitment to advancing patient care. I believe in fostering a culture of collaboration and teamwork as well as empowerment within the organization. By encouraging open communication and valuing diverse perspectives, I ensure that decisions are well-informed and reflective of the collective wisdom of the team. Let’s dive into the details below! Wolfgang, can you share with our readers a brief overview of your professional journey that led you to ® establish joimax ? As a trained telecommunication technician, I graduated from evening high school and I studied medicine later in Vienna. That was the ideal prerequisite for combining medicine and engineering to constantly drive new ideas. My motivation has always been to help people, and I have April 2024 www.eurohealthleaders.com 31

34. If there are problems within this complex system specialists are required and special technologies are needed to treat as gentle but also powerful as possible the various diseases. In 2000 I arrived in the spine field and on one hand I was shocked, how crude standard surgery was still done for small diseases then, and on the other hand how well and fast I could develop specific instruments and tools for curing with first pioneering surgeons such widespread diseases. joimax focuses on innovative technologies, systems and methods for endoscopic minimally invasive spinal surgery. On one hand, we guarantee the best possible and particularly gentle treatment technologies for patients and, on the other hand, complete systems ensure that the surgeon can work most safely and cost-optimized on a daily basis. ® In line with the joimax philosophy “Endoscopic Spine Experts”, we develop professional medical applications using endoscopy - always adapted to the increasing needs of users and patients globally. joimax constantly tries to implement the latest scientific findings and technologies. In addition, the day-to-day practical experience of our customers and their ongoing feedback helps us to continuously improve our products and processes. ® Endoscopic minimally invasive spinal surgery has the potential to make a significant impact on patient care and healthcare delivery. By minimizing surgical trauma, reducing hospital stays, and speeding up recovery times, these techniques not only benefit individual patients but also contribute to overall healthcare efficiency and cost-effectiveness. This potential for highly meaningful clinical impact motivates me to focus efforts on advancing endoscopic spinal therapy. ® How does joimax differentiate itself in the market, and what sets it apart in the field of endoscopic minimally invasive spinal surgery? ® What is the core mission of joimax , and how does it guide the company’s strategic direction under your leadership? joimax offers highly specialized complete systems for endoscopic minimally invasive spinal surgery techniques and is fully focused on this market segment. ® ® April 2024 www.eurohealthleaders.com 32

35. Our strength lies in the development, manufacturing, marketing and even educating and training of all application systems, methods and devices to users around the globe. On the base of over 500 patents and trademarks to date joimax products are marketed in more than 60 countries, in Europe, America, Asia, Middle East and Africa. Under ESPINEA , the in 2019 inaugurated and joimax powered “Endoscopic Spine Academy,” more than 6,000 surgeons had been trained on the more than 15 systems for treating spinal diseases. Having a clear vision of the company’s purpose, goals, and direction provides a roadmap for success. This vision inspires and motivates both myself and my team to work towards common objectives, but also users facing the ® enthusiasm of joimax employees acting as a team driven by patient demand. Focus on our mission and prioritization on currently required tasks and duties had always been and will be key drivers for our long term and lasting success. ® ® ® Embracing innovation and fostering a culture of creativity and forward thinking enables us to stay ahead of the curve in a rapidly evolving industry. Placing the needs and interests of our customers at the center of everything we do ensure that our products and services are relevant, valuable, and impactful. Building strong customer relationships and actively soliciting feedback helps us continuously improve and adapt to changing market demands. Our surgical solutions enable the gentlest possible treatment, always with the patient’s well-being in mind. All systems and applications are constantly monitored and users ongoingly publish their findings and results with ® joimax systems treated patients in international well recognized journals. Outstanding product quality is guaranteed by certified quality management systems in place in accordance with international standards. In addition, products are “Made in Germany”. Above all that, ® joimax is constantly expanding the range of methods, instrument sets and the associated electronic devices. Recognizing that individual success, but also global acting ® joimax teams performance, together with our customers, has to do with looking in every detail for being collectively a top performer. I value very high collaboration, teamwork, and diversity of thought within my organization. How do you approach leadership and decision-making ® within joimax , considering your extensive experience in healthcare and business? Could you highlight a significant challenge you faced in your career and how you overcame it to drive joimax ’s growth? ® My approach is always multifaceted and adaptable to the specific needs and challenges of the organization and industry. I believe in fostering a culture of collaboration and teamwork as well as empowerment within the organization. By encouraging open communication and valuing diverse perspectives, I ensure that decisions are well-informed and reflective of the collective wisdom of the team. This approach not only enhances the quality of decision-making but also promotes employee engagement and ownership. We started to FDA register joimax products in 2005 already ® and incorporated joimax Inc. as a Delaware corporation in 2006. Until 2011 we could start developing the endoscopic spine surgery market in the USA, but as of January 2012 the reimbursement all of a sudden was blocked due to a new language in the AMA (American Medical Association) CPT Codebook. From that time onwards only cash pay and very special indications for endoscopic spinal procedures had been reimbursable. On this basis one of our start-up competitors went bankrupt and others left the US market. Together with our investors we analyzed the situation and finally decided that I will fight the US reimbursement system for obtaining a specific reimbursement schematic, which took 5 years to achieve. ® The healthcare industry is characterized by rapid technological advancements and changes, evolving regulatory frameworks, and shifting patient demands and needs. In such a dynamic environment, I prioritize adaptability and agility in leadership and decision-making processes. This entails being receptive to change, proactively seeking opportunities for innovation, anticipating market needs and swiftly adjusting course when necessary. As of January 2017, the new AMA CPT Codebook contained the special language which from that time onwards allowed reimbursement of endoscopic spinal surgery procedures. Moreover, even a special reimbursement code was released stimulating a clear ramp-up of business activity and adoption of endoscopic spinal surgery in the USA. Today US surgeons are key drivers in highly ranked publications in top journals studying the significant cost-/outcome benefit ratios of What key values or principles do you believe have been crucial to your success as the CEO and Founder of ® joimax ? April 2024 www.eurohealthleaders.com 33

36. endoscopic spinal surgery versus traditional open surgery methods. Don’t let fear of failure hold you back from pursuing innovative ideas or opportunities. Learn from mistakes, take those to heart, rise up again and keep driving your ideas to your mission where you are assured new solutions can have its place and finally will be needed. What advice would you share with aspiring healthcare professionals and entrepreneurs looking to make a difference? You will be needed within a special space of activity you identify for yourself. Healthcare has always been but is even more ripe for innovation today, with endless opportunities to improve processes, develop new treatments, and enhance patient care. Embrace innovation and be open to exploring novel ideas and technologies that have the potential to revolutionize the industry. Stay abreast of the latest developments, trends, and challenges in healthcare. Continuously educate yourself through reading journals, attending conferences, and engaging in professional development activities to remain informed and be up to speed in your field. Always prioritize the needs and well-being of patients. Listen to their concerns, involve them in decision-making, and strive to deliver personalized, compassionate care that meets their individual preferences and values. April 2024 www.eurohealthleaders.com 34

38. Transforma?onal and Emo?onal Competence Healthcare Leadership in the Digital Age T this whirlwind of change, healthcare organizations are struggling with the challenge of adapting and succeeding in the digital age. Effective leadership has emerged as a critical success factor, with a growing emphasis on the complementary competencies of transformational leadership and emotional intelligence. he healthcare industry is being reshaped by the forces of digital transformation, introducing new technologies, care delivery models, and patient expectations. Amidst Let us explore how these leadership styles can help attain success in the digital age! Transformational Leadership: Catalyzing Innovation and Driving Change This is a leadership approach that inspires followers to transcend their self-interests for the greater good of the organization. In the context of healthcare, transformational leaders play a crucial role in championing innovation, of cultivating a culture of continuous improvement, and effectively navigating organizational change. At the core of transformational leadership is the ability to articulate a compelling vision for the future. This vision should not only encompass technological advancements but also prioritize patient-centered care, quality improvement, and operational efficiency. By painting a clear picture of the desired future state, transformational leaders can rally their teams around a shared purpose and inspire them to embrace the changes necessary to realize that vision. Moreover, transformational leaders must create an environment that encourages creativity and innovation. Healthcare organiza- tions that cultivate a culture of psychological safety, where employees feel comfortable voicing their ideas and challenging April 2024 www.eurohealthleaders.com 36

39. April 2024 www.eurohealthleaders.com 37

40. the status quo, are better positioned to drive innovation and stay ahead of the digital curve. conflicts constructively – all of which are essential for driving organizational change and fostering a cohesive, high-performing team. Empowering teams and encouraging their participation in decision-making processes is another hallmark of transformational leadership. By delegating authority and involving team members in the change process, transformational leaders can foster a sense of ownership and commitment, ultimately increasing the likelihood of successful change implementation. Integrating Transformational and Emotional Compe- tence While transformational leadership and emotional intelli- gence are distinct concepts, they are inextricably linked in the context of effective healthcare leadership. Transformational leaders who possess emotional intelli- gence are better positioned to inspire and motivate their teams, build trust and credibility, and navigate the complex- ities of the digital age with grace and resilience. Emotional Intelligence: Building Trust, Resilience, and Collaboration While transformational leadership focuses on driving change and innovation, emotional intelligence is equally crucial for healthcare leaders in the digital age. Emotional intelligence encompasses self-awareness, self-regulation, motivation, empathy, and social skills – all of which are essential for building trust, fostering resilience, and navigating the emotional complexities inherent in healthcare settings. Emotionally intelligent transformational leaders can leverage their self-awareness and empathy to tailor their communication and change management strategies to the unique needs and concerns of their teams and stakeholders. By actively listening and addressing concerns with empathy and compassion, they can facilitate a smoother transition to new digital healthcare models and technologies, while minimizing resistance and fostering buy-in. Self-awareness, the cornerstone of emotional intelligence, allows healthcare leaders to have a deep understanding of their strengths, weaknesses, values, and emotions. This self- knowledge enables them to make informed decisions, manage their emotions effectively, and lead with authentic- ity, which is essential for building trust and credibility among their teams and stakeholders. Moreover, emotionally intelligent transformational leaders can role model the behaviors they seek to cultivate in their teams. By demonstrating self-regulation, resilience, and a growth mindset, they can inspire their teams to embrace change, learn from setbacks, and continuously develop their skills and capabilities – essential attributes for thriving in the rapidly evolving digital healthcare landscape. Empathy, another key component of emotional intelligence, is particularly important in the healthcare context. Leaders who can empathize with their teams, patients, and families are better equipped to provide compassionate care and create a supportive environment that prioritizes the well- being of all stakeholders. Conclusion In the era of digital transformation, healthcare organizations are facing unprecedented challenges and opportunities. Navigating this complex field demands a unique blend of leadership competencies that combines the visionary and change-driving qualities of transformational leadership with the interpersonal and emotional intelligence skills necessary for building trust, fostering resilience, and facilitating effective collaboration. By integrating these complementary competencies, healthcare leaders can inspire and guide their organizations through the digital age, delivering better patient outcomes and a more sustainable, future-ready healthcare system. Furthermore, emotional intelligence enables healthcare leaders to build resilience – a critical skill in the face of the ever-changing digital landscape. By effectively managing their emotions and maintaining a positive outlook, emotion- ally intelligent leaders can weather the storms of change and uncertainty, while inspiring their teams to do the same. Collaboration and effective communication are also facilitated by emotional intelligence. Leaders who possess strong social skills can build and maintain productive relationships, facilitate open dialogue, and navigate - Natalie May April 2024 www.eurohealthleaders.com 38

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43. Innovation distinguishes between a leader and a follower.

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