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DOE Genomics:GTL Roadmap

DOE Genomics:GTL Roadmap. BERAC Advisory Committee Meeting. April 30, 2004. John Houghton ... (1) DEVELOPMENT OF PLAN. Not later than 1 year after the date of enactment of this Act, ...

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DOE Genomics:GTL Roadmap

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    1. DOE Genomics:GTL Roadmap

    BERAC Advisory Committee Meeting April 30, 2004 John Houghton John.Houghton@science.doe.gov

    2. Energy Bill (not passed) Requires Roadmap

    (c) PLAN (1) DEVELOPMENT OF PLAN.—Not later than 1 year after the date of enactment of this Act, the Secretary shall prepare and transmit to Congress a research plan describing how the program authorized pursuant to this section will be undertaken to accomplish the program goals established in subsection (b). (2) REVIEW OF PLAN.—The Secretary shall contract with the National Academy of Sciences to review the research plan developed under this sub-section. The Secretary shall transmit the review to Congress not later than 18 months after transmittal of the research plan under paragraph (1), along with the Secretary’s response to the recommendations contained in the review. NSF recently advised to make more use of roadmaps for facilities

    3. Roadmap Outline

    Executive Summary: Introduction; *Vision: Frazier Science and the Research Plan: Facilities: Computation: *Environmental Remediation: Fryberger, Bolton, Hochella *Energy: Houghton, Davison, Siebert *Terrestrial sequestration and climate science: Amthor, Rogers *Ocean sequestration and climate science: Drell, Armbrust Ancillary Benefits: basic science, unforeseen events, etc. ELSI: Governance: * breakout session attached to GTL meeting March 3,4

    1. Problem Statement: The problem that exists and the solution that is sought. 2. Vision for 20XX: 3. Mission End Points And Requirements 4. Today’s State of The Art in Knowledge And Capabilities 5. Major Milestones in Science and Capabilities ………. ……… ……. ….. … … . ………. ……… ……. ….. … … . ………. ……… ……. ….. … … . ………. ……… ……. ….. … … . March 3 Template for Functional Roadmap – In sequence 1. Problem Statement: The problem that exists and the solution that is sought. 2. Vision for 20XX: 3. Mission End Points And Requirements 4. Today’s State of The Art in Knowledge And Capabilities 5. Major Milestones in Science and Capabilities ………. ……… ……. ….. … … . ………. ……… ……. ….. … … . ………. ……… ……. ….. … … . ………. ……… ……. ….. … … . March 3 Template for Functional Roadmap – In sequence March 4: Delineate Technologies and Computing T T T T C C C T T T T C C C T T T T C C C T T T T C C C PHOTOSYNTHETIC PATHWAYS (light reactions) O2 2H2O PS II PQ-pool PS I Fd H2ase H2 e- e- Chl antenna Chl antenna CO2 starch Sun H+ H+ H+ ADP + P ATP H+ INSIDE OUTSIDE MEMBRANE ANTENNA ORNL WSC24335 Carbon Fixation and Sequestration Agriculture Land Forest Land Wetlands Degraded Lands Liquid Fuels Biogas Biopower Biohydrogen Bioenergy and Carbon Cycling Biopolymers and Plastics Food, Feed, and Fiber Specialty Products Bioproducts and Carbon Cycling Basic Plant Research Water Management Photosynthetic Efficiency Nutrient Use Efficiency Cell Wall Assembly COFixation 2 Genomics and Gene Expression

    8. Selected Clean Energy Capabilities

    Protein production Improved heterologous expression. Suite of heterologous expession hosts (i.e., control the redox state, codon usage, small molecule partners, and recombinant production of metal-containing proteins). Assays Measure target metabolite in situ (# per cell). Design assays to match cellular milieu. Activity-based assays. Rational design of molecular machines Survey diversity of hydrogenases or glycosyl hydrolyses. Full characterization of partners, energetics, structures, PTMs, etc. Computation tools for rational design/recombination.

    9. Selected Clean Energy Technology Requirements

    Imaging Needs: Single Molecule Sensitivity Molecular to >cm scale, 3-D resolution High sensitivity and spatial resolution MR including phosphorus and 13C X-Ray and Electron based microscopies High sensitivity optical with enhanced spatial resolution Imaging of opaque samples The ability to make multiple assays simultaneously Combined scanning probe (AFM, STM, nano-sensor) and optical imaging Simultaneous use of multiple optical probes Two/Three Photon, CARS, High-Speed, SERS, FRET, FLASH, etc. Simultaneous MR/Confocal and Scanning-MS/Confocal Real-time, 3-D measures of time and spatial distributions Redox potential, protein & metabolite concentrations, lipids, energetic species, cofactors, etc. Molecular probes Highly sensitive, multiple analytes, functionally sensitive, inert, and accessible to the cell interior. Affordable and accessible Tools User facilities should foster the development and export of easily usable versions of new technologies.

    10. Products of Technology Deep Dive Specifications Workshop

    Science Driven Capabilities specifications Analysis of technologies specifications related to identified capabilities – identifying strengths, weaknesses, and gaps Roadmaps for development of technologies to required performance Analysis of computing needs of science, capabilities, and technologies Roadmaps for computing environment development Analysis of natural groupings or suites of technologies which might drive facilities specifications.

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