Top 5 Alzheimer's Disease Solution Providers

Top 5 Alzheimer's Disease Solution Providers Health Everything are Transforming Healthcare www.healthcareeverything.com Oct Issue 04 2023 Transformative Approaches Revolutionizing Alzheimer's Treatment Alzheimer's and Memory Understanding the Mechanisms Behind Cognitive Decline Trevor P. Castor President & CEO Aphios Corporation Aphios Corporation Inspired by Nature and Personal Tragedy, Aphios is Taking a Different and Sustainable Approach to Addressing Alzheimer's Disease and Cognitive Dementia

THOUGH THOSE WITH ALZHEIMER’S MIGHT FORGET US, WE AS A SOCIETY MUST REMEMBER THEM - Scott kirshenbaum

Editor’s Note Innovating Hope I doctors. That’s why, in this special edition of Healthcare Everything, we’re digging deep into the world of Alzheimer’s. We want to understand it better and learn about the exciting new treatments and methods that give us hope for the future. n the homes of many families, Alzheimer’s disease brings a heavy heartache. It’s not just a challenge for those who have it but also for their families and This isn’t just about finding a cure; it’s about making life better for people living with Alzheimer’s right now. We’ll share stories of courage and discovery, showing you how ordinary people are doing extraordinary things to fight this disease. So, come along with us on this journey. Let’s explore the hope and determination changing how we think about Alzheimer’s. In these pages, you’ll find the human side of the story – the struggles, the victories, and the incredible progress that gives us a reason to believe in a brighter tomorrow. Imagine Alzheimer’s like a tricky puzzle where people slowly lose their memories and ability to think clearly. For a long time, doctors and scientists have struggled to solve this puzzle. But now, things are changing. We’re learning more, and that knowledge is changing how we care for people with Alzheimer’s. Hope you have an informative read! In this recent edition,Top 5 Alzheimer’s Disease Solution Providers, we’re closely examining our progress. We’re talking about the smart and creative ways doctors and scientists approach Alzheimer’s. They’re using new techniques and treatments like shining lights in the darkness of this disease. Pja Sh -Pooja Shah

v e o C r Mitochon Pharmaceuticals 08 20 Channeling the Ability of Mitochondria to Create Resilient, Protective Cells in Neurodegeneration and Aging North Star Senior Advisors 28 Providing a Guided Path for Senior Living Alzheimer's and Memory 16 Inspired by Nature and Personal Tragedy, Aphios is Taking a Different and Sustainable Approach to Addressing Alzheimer's Disease and Cognitive Dementia Understanding the Mechanisms Behind Cognitive Decline Transformative Approaches 24 Revolutionizing Alzheimer's Treatment

Chidiebere Moses Ogbodo Editor-in-Chief Pooja Shah Nisha Mehra Managing Editor Executive Writer Top 5 Alzheimer's Disease Solution Providers David King Sameen Arif Visualiser Art & Design Head Paul Belin Deepanjali Jena Co-designer Art & Picture Editor Eric Jackson Carol Wilson Business Development Manager Marketing Manager James Vincent, Brian Cooper Nick, Elisha and Mary Business Development Executives Sales Executives Jacob Smith Prashanth Hiremath Technical Head Featuring Person Company Brief Assistant Technical Head David, Robert Technical Consultants Aphios Corporation is a biotechnology and nanotechnology company that develops green drug delivery platforms and enhanced therapeutic products for health. Aphios Corporation aphios.com Dr. Trevor P. Castor President & CEO Alina Sege Nikita Khadalkar Digital Marketing Manager Assistant Digital Marketing Manager Gemson SME-SMO Executives Coya Therapeutics is a clinical-stage biotech company focused on developing multiple Treg- modulating therapies for neurodegenerative, autoimmune, and metabolic diseases. Coya Therapeutics coyatherapeutics.com Howard Berman Founder and CEO Carl Vincent Research Analyst Tanaji Fartade Circulation Manager Mitochon Pharmaceuticals is a clinically staged biotech that is focused on developing drugs that target the mitochondria for a host of serious diseases with significant unmet medical needs. sales@healthcareeverything.com John Geisler Co-Founder & CSO Mitochon Pharmaceuticals mitochonpharma.com October, 2023 Contact Us: North Star Senior Advisors is a company that provides a free guided path to senior living by locating communities that meet the needs of seniors and their families. Insights Success Media Tech LLC 555 Metro Place North, Suite 100, Dublin, OH 43017, United States Phone - 614-602-4132 Email: info@healthcareeverything.com For Subscription: www.healthcareeverything.com Insights Success Media and Technology Pvt. Ltd. Survey No.133/134, Brand Square, Office No. 512, Kunjir Chowk, Pimple Saudagar, Pune, Maharashtra 411027. Phone - India: 7410033802, 8956487823 Email: info@healthcareeverything.com For Subscription: www.healthcareeverything.com Ignacio Quinones President North Star Senior Advisors northstarsa.com Wesley Manor Retirement Community is a senior living provider that offers a full continuum of care options, from independent and assisted living to memory care and skilled nursing. Wesley Manor Retirement Community wesman.org Raymond A. Dickison President Follow us on : www.facebook.com/Healthcareeverything/ https://twitter.com/healthcareeverything We are also available on : Copyright © 2023 Insights Success Media and Technology Pvt. Ltd., All rights reserved. The content and images used in this magazine should not be reproduced or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from Insights success. Reprint rights remain solely with Insights Success Media and Technology Pvt. Ltd. Healthcare Everything is powered by Insights Success Media and Technology Pvt. Ltd.

Based on Aphios' technology platforms, we are developing enhanced therapeutic products for cancers and supportive care, infectious diseases such as HIV, and CNS disorders including Alzheimer's disease, pain and opioid addiction in an environmentally-sustainable manner.

Top 5 Alzheimer's Disease Solu?on Providers A Founder—where his mother-in-law not only failed to recognize him and his wife but also stopped eating and passed away at the age of 70—he and his team knew that it was time to develop innovative solutions to such a devastating condition. Inspired by nature, this event catalyzed them to start Aphios Corporation. lzheimer's disease could be a frightening disease to witness and/or experience. When a tragic life event hit the the Frost & Sullivan North American Nanodrug Excellence in Healthcare Technology Innovation Award, Santa Fe, NM, and Cleantech Venture and Partnering Award, Pharma & Biotech, Santa Clara, CA as well as recognition as a top Alzheimer's disease solution developer. and sad process to watch a vibrant woman with an inquisitive and thoughtful intellect wither away and die, unlike the quick fading of a beautiful flower," says the Founder. He continues, "Her physician estimated that her symptoms began around the age of 50, with each decade demonstrating a significant decline in cognitive functioning. The death of an Alzheimer's disease patient begins long before the physical signs of life cease to function. Patients are lost in their own, isolated neurological space." Overall, Aphios Corporation is a biotechnology company that is making a meaningful difference in the lives of patients suffering from Alzheimer's disease and other debilitating conditions. Its commitment to sustainability, innovation, and scientific excellence is evident in all aspects of its work, from drug discovery and delivery to business operations. Aphios Corporation is a green biotechnology company that is taking a different approach to addressing Alzheimer's disease and other medical conditions. Driven by a commitment to sustainability and innovation, the company has developed several enabling technology platforms that improve drug discovery and manufacturing, pathogenic drug safety, and nanotechnology drug delivery. One of its flagship proprietary nanotechnology platforms based on SuperFluids™ allows for the efficient delivery of natural products to the brain. This technology platform has shown promise in preclinical models of Alzheimer's disease, and the company is now exploring its potential in other neurological disorders such as multiple sclerosis. Alzheimer's disease and dementia are debilitating diseases affecting over 6.7 million people in the United States and over 55 million people worldwide. Black Americans are twice as likely Let's dive in to learn about the company's innovative and sustainable operations to address Alzheimer's Disease and Cognitive Dementia. Source of Inspiration Trevor P. Castor President & CEO Aphios Corporation Alzheimer's disease is a debilitating and frightening disease for everyone but especially when you encounter it first-hand. The Founder's mother-in-law Dr. Alma Lowry-Palmer was a Professor of Nursing at the University of Tennessee Medical School. She was going to the wrong classrooms and making errors in scheduling and teaching and eventually wandered off to her home turf in California. She was 58 years old. He brought her back to live with his family in Massachusetts where she was diagnosed at the MGH- Memory Disorder Clinic with Alzheimer's disease. Aphios' focus is on developing environmentally- sustainable therapeutic products for a range of medical conditions, including Alzheimer's disease and cancers. It thus develops several novel therapies from medicinal plants and marine organisms, leveraging their ability to manage cellular replication without mutation and live for hundreds of years. Aphios Corporation was founded with a mission to prevent disease, maintain health and improve quality of life, and, if it could not, to treat certain chronic diseases such as Alzheimer's disease, cancers, HIV and supportive care in an environmentally sustainable manner while minimizing climate change. "After further debilitation and memory lapse errors, we decided it would be safer for her to be placed in a memory care facility. At some point, she failed to recognize my wife and me but was aware of her two grandsons' presence. Around the age of 70, she stopped eating, passing away within 60 days. An autopsy indicated she had died of Alzheimer's disease. It was a slow, arduous, The company's dedication to sustainability extends beyond its drug development efforts. It is committed to minimizing its environmental impact, using sustainable and ethical practices in all aspects of its business operations. Aphios has received several awards for its efforts, including

HIV/AIDS, influenza, and COVID-19, and CNS disorders including Alzheimer's disease, pain and opioid addiction in an environmentally- sustainable manner," says the Founder. Aphios has also developed SuperFluids™ to pretreat cellulosic biomass for ethanol manufacturing and the production of biofuels from cellulosic waste as well as algae. He continues, "In our journey, we utilized SuperFluids™ to first discover and then manufacture our lead Alzheimer's disease therapeutic from a marine organism. We used scuba divers to harvest this abundant and invasive species off the southern coast of California. We have found that this compound not only prevents the formation of amyloid plaques but stimulates the formation of synapses." "We believe that while the prevention of amyloid plaques is necessary for the treatment of Alzheimer's disease, it is not sufficient for a cure. While most of the FDA-approved Alzheimer's disease drugs only partially treat the symptoms of the disease, a drug by Biogen and Eisai was recently approved by the FDA because it reduced the formation of amyloid plaques." improving healthcare outcomes in an environmentally sustainable manner. They have developed several enabling technology platforms for improving drug discovery and manufacturing, pathogenic drug safety and nanotechnology drug delivery. These technologies are based on exploring the properties of naturally occurring, nontoxic SuperFluids™. When compressed, these fluids exhibit enhanced thermodynamic properties of penetration, selection, solvation and expansion. They simultaneously behave like a gas and a liquid, having properties of both. Aphios has explored the unique properties of SuperFluids™ on a cellular level to minimize product degradation and to eliminate or significantly reduce toxic organic solvent usage. To improve our therapeutics for Alzheimer's disease patients, we are pursuing the discovery of new molecules that will improve our extant product being developed, as well as combination therapies to combat the complex biology of the brain and the management of genes that are associated with dementia and Alzheimer's disease. "While this is a great achievement, we do not believe it is sufficient enough to reverse or cure Alzheimer's disease. Additionally, it was only approved for early-stage dementia or early-stage Alzheimer's disease and there is a potential for brain swelling side effects. Our approach is to both prevent the formation of amyloid plaques and regenerate synapses through synaptogenesis to recover both long- and short-term memory," explains the Founder. as white Americans, and Hispanics are about 1.5x times the rate of white Americans to be impacted by Alzheimer's disease. "What are the causes and what are the reasons? These questions and my experience with Alma combined with the drive to protect my wife whom I love, have inspired my quest to address this horrible disease," says the Founder. Aphios' Approach to Addressing Alzheimer's Disease From the Depths of the Ocean "Based on these platforms, we are developing enhanced therapeutic products for cancers and supportive care, infectious diseases such as Alzheimer's disease is associated with multiple factors, including but not limited to amyloid From its very inception, Aphios Corporation under the Founder's leadership has focused on

mice, which was reversed by inhibiting this receptor. The company is also focused on reducing brain inflammation and swelling caused by anti-amyloid drugs, and envisions combination drugs to address Alzheimer's disease and cognitive dementia. entrepreneurs to manage memory and aging. These targets, new and old, remain challenged by the blood-brain barrier (BBB) that protects our brain from adventitious and therapeutic molecules. Thus, drug delivery to the brain will remain, as it is today, the Trojan horse that will transport therapeutic molecules across the BBB so that they can manage enzymes, synaptogenesis and genes in our brain. For example, we have explored the impact of microgravity on the International Space Station for making nanoparticles into smaller particles that approach molecular dimensions to improve penetration into the brain across the BBB." As our knowledge of biology, the brain, and aging increase with the significant amount of fundamental research being conducted, new targets will be discovered generating new opportunities for scientists, engineers and entrepreneurs to manage memory and aging. Mission and Vision Aphios Corporation is a "green" biotechnology company. It follows the ESG principles. Aphios Corporation was founded with a mission to prevent disease, and maintain health and improve quality of life, and, if it could not, to treat certain chronic diseases such as Alzheimer's disease, cancers, HIV, and supportive care in an environmentally sustainable manner while minimizing climate change. Scaling 2023 and Beyond Looking at the future ahead, in 2023 and beyond, the company plans to scale its services and operations by establishing financial and strategic corporate partnerships to progress its lead Alzheimer's disease drugs that target amyloid reduction, synaptogenesis and brain inflammation through a Special Purpose Vehicle (SPV). "We also plan to work with our university partners and contract research organization to accelerate our drug development activities to bring these drugs to Alzheimer's disease patients in need of treatment," adds the Founder. The company's vision is not only to treat but develop cures for certain diseases like Alzheimer's disease and HIV. "We have been inspired by nature and enabled by science to develop enhanced therapeutic products from medicinal plants that have learned how to manage cellular replication without mutation, marine organisms such as some sharks that can live for hundreds of years, and our amazing biology," adds the Founder. therapeutic modalities for Alzheimer's disease. We look forward to their support in our journey to address this debilitating disease," says the Founder. Endeavors at Present and in the Far Frontiers of Space plaque formation, tau protein entanglement, enzyme activity, and inflammation. "To improve our therapeutics for Alzheimer's disease patients, we are pursuing the discovery of new molecules that will improve our extant product being developed, as well as combination therapies to combat the complex biology of the brain and the management of genes that are associated with dementia and Alzheimer's disease. We are particularly focused on a specific gene that could be knocked down by small molecules and siRNA to improve patient's memories," explains the Founder. As humans age, certain neuronal enzymes in their bodies degrade. Enzymes are protein catalysts that will typically promote the reaction between other proteins. Eventually, after repeated reactions, they do degrade. In some respects, they are very similar to catalytic converters in cars that eventually degrade with use. Aphios is focused on targeting enzymes that are responsible for the formation of amyloid plaques and the regeneration of synapses. "I remain inspired to develop solutions for Alzheimer's disease from my experience with Dr. Alma Lowery-Palmer who always said, 'I know you can do it,'" concludes the Founder. Leveraging Technological Support To advance Aphios' products through the clinic, the company needs both financial and technological support to accelerate development plans. The former would come from thoughtful and passionate investors, institutions and individuals. "Our progress will be facilitated by experienced contract research organizations, healthcare providers and nonprofit companies. Of course, approvals by the regulatory authorities are a must. The FDA and other regulatory agencies have proven in the past few years to be very encouraging in the advancement of new Inflammation is implicated in many aging diseases; in the central nervous system (CNS), it is associated with the CCR5 gene that increases with age. CCR5 has been correlated with impairments in memory consolidation in aged He continues, "As our knowledge of biology, the brain, and aging increase with the significant amount of fundamental research being conducted, new targets will be discovered generating new opportunities for scientists, engineers and

Alzheimer’sandMemory Neurological Foundations of Memory- The Basics Memory, the cornerstone of cognition, is a product of intricate neural networks and communication between brain cells or neurons. When we learn something new or experience an event, specific neurons in the brain form connections, creating a memory trace. These connections, called synapses, enable the neurons to communicate. It’s akin to a vast, bustling city where messages zip through the neural highways, allowing us to recall past events, learn new information, and make decisions. M emory is the fundamental building block of our experiences, feelings, and identities inside the complex network of the human brain. Our lives are colourful and varied; memory weaves them together to create beautiful events. This mixture is susceptible to deterioration, though. Cognitive decline can arise from memory threads fraying over time, sometimes prematurely. One of the most severe manifestations of this deterioration is Alzheimer’s disease, a degenerative neurological condition that affects memory and other cognitive abilities. Understanding the Mechanisms Behind Cogniti Decline 16 | October 2023 ve At its core, Alzheimer’s is a complex puzzle that challenges researchers and scientists aiming to understand its complex mechanisms. To truly comprehend the enigma of cognitive decline, one must delve into the depths of the brain, exploring the tangled pathways and neural connections that underpin our ability to remember. www.healthcareeverything.com 17 | October 2023 www.healthcareeverything.com

Subscribe Today Alzheimer’s Disease- Resolving the Mystery have the power to modify lifestyle choices, aiming to reduce the risk of Alzheimer’s. Regular physical activity, a balanced diet rich in antioxidants and omega-3 fatty acids, and social engagement can strengthen the brain’s resilience, delaying the onset of cognitive decline. In Alzheimer’s disease, neural communication undergoes a tragic transformation. The hallmark of Alzheimer’s is the accumulation of abnormal protein deposits in the brain. Two types of protein, beta-amyloid and tau, misfold and clump together, forming plaques and tangles, respectively. These plaques and tangles disrupt the normal functioning of neurons, impeding their ability to communicate effectively. Hope on the Horizon- Advances in Research and Treatment While the mechanisms behind Alzheimer’s remain complex, researchers are making remarkable strides in understanding the disease. Advances in neuroimaging techniques, such as PET scans, allow scientists to visualize beta-amyloid plaques in living brains, aiding in early diagnosis and tracking disease progression. Additionally, ongoing clinical trials explore novel treatments, including immunotherapies targeting abnormal proteins and drugs to modulate neuroinflammation. Stay in touch. Imagine a library where books (representing memories) are stored on neatly organized shelves. In a healthy brain, librarians (neurons) can easily access these books. However, in Alzheimer’s, the shelves become cluttered with misfolded, sticky proteins, making it difficult for the librarians to retrieve the books. This disruption in information retrieval leads to memory loss and cognitive decline. Subscribe to Healthcareverything Get Insightssuccess Magazine in print, & digital on www.healthcareeverything.com The Role of Neuroinflammation Moreover, research into lifestyle interventions, such as cognitive training and personalized exercise programs, offers hope for enhancing brain health and delaying cognitive decline. These interventions utilize the brain’s remarkable plasticity and ability to reorganize and form new neural connections, even in Alzheimer’s pathology. Beyond protein abnormalities, neuroinflammation, a response of the brain’s immune system, plays a significant role in Alzheimer’s progression. When the brain detects the presence of abnormal proteins, immune cells are activated. While this response is the body’s attempt to clear the harmful proteins, chronic inflammation can cause collateral damage, harming healthy neurons and further impairing cognitive function. Never Miss an Scientists keep looking into the intricate web of brain connections, strange proteins, and immunological responses to figure out the mysteries of Alzheimer’s and memory loss. While a definitive solution remains elusive, academics’ cooperative efforts and the focus on leading healthy lives offer a glimmer of optimism. Understanding the complexities of cognitive decline is not just an academic pursuit; it is a ray of hope, pointing us toward a time when memories will be clear and our life stories will be passed down through the generations. Issue Think of neuroinflammation as a double-edged sword. On the one hand, it’s the brain’s defense mechanism, attempting to protect itself from invading abnormal proteins. On the other hand, prolonged inflammation can exacerbate neural damage, contributing to the relentless progression of Alzheimer’s. Genetics and Environmental Factors- A Complex Interplay Genetic factors also play a role in Alzheimer’s disease. Certain gene variants cause the risk of developing this condition. These genes influence various aspects of brain function, including the production and clearance of beta- amyloid protein. However, genetics only tell part of the story. Environmental factors, such as cardiovascular health, diet, exercise, and social engagement, also significantly impact the risk of cognitive decline. -Pooja Shah CORPORATE OFFICE Insights Success Media Tech LLC 555 Metro Place North, Suite 100, Dublin, OH 43017, United States Phone - (614)-602 - 1754,(302)-319-9947 Email: info@healthcareeverything.com For Subscription : www.healthcareeverything.com Check should be drawn in favor of : INSIGHTS SUCCESS MEDIA TECH LLC Consider genetics as the loaded gun and lifestyle factors as the trigger. While we can’t change our genetic makeup, we 18 | October 2023 www.healthcareeverything.com

Top 5 Alzheimer's Disease Solution Providers 20 | October 2023 www.healthcareeverything.com 21 | October 2023 www.healthcareeverything.com

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Revolutionizing Alzheimer’s Treatment A lzheimer’s disease is a complex medical science puzzle that has long been difficult to solve despite years of dedicated effort by researchers, physicians, and families worldwide. With incredible progress made in recent years, the field of Alzheimer’s treatment is changing dramatically and providing patients and their families with new opportunities and hope. Understanding Alzheimer’s- Decoding the Enigma To revolutionize Alzheimer’s treatment, it is essential to delve into the heart of the matter: understanding the disease itself. Alzheimer’s, a progressive brain disorder, manifests primarily as memory loss, cognitive decline, and behavioral changes. At its core lies the abnormal accumulation of proteins in the brain, forming plaques and tangles. Decades of research have led scientists to uncover various factors contributing to the disease, including genetic predisposition, lifestyle choices, and environmental influences. Precision Medicine- Tailoring Treatments to Individuals One of the most promising avenues of Alzheimer’s treatment is precision medicine. This approach recognizes that each patient is distinct, and their response to treatment may vary significantly. Using advanced genetic testing and analysis, doctors can now identify specific genetic markers associated with Alzheimer’s risk. Armed with this knowledge, they can tailor treatments, therapies, and medications to suit individual patients, optimizing the effectiveness of interventions and potentially slowing down the progression of the disease. 24 | October 2023 www.healthcareeverything.com 25 | October 2023 www.healthcareeverything.com

Immunotherapy- Connecting the Power of the Immune System significantly reduce the risk of developing Alzheimer’s. Moreover, these lifestyle choices are now being integrated into comprehensive treatment plans, empowering patients to actively participate in their own well-being. As the phrase goes, prevention is more effective than cure, and in the case of Alzheimer’s, lifestyle interventions offer a proactive approach to combating the risks associated with this devastating disease. Immunotherapy, a groundbreaking approach in the fight against Alzheimer’s, harnesses the body’s immune system to target and eliminate harmful proteins in the brain. Researchers have developed experimental vaccines and antibodies designed to recognize and remove beta-amyloid plaques, a hallmark of Alzheimer’s pathology. These innovative therapies aim to not only halt disease progression but also promote the regeneration of brain cells, offering a glimmer of hope in the quest for a cure. Conclusion- A Hopeful Tomorrow In the ever-changing landscape of Alzheimer’s treatment, these transformative approaches pave the way for a future where the diagnosis is not synonymous with despair. Precision medicine, immunotherapy, cognitive rehabilitation, targeted drug therapies, and lifestyle interventions represent the threads of a new narrative—one where Alzheimer’s is understood, targeted, and, ultimately, conquered. Neuroplasticity and Cognitive Rehabilitation- Exercising the Brain In the ever-evolving field of Alzheimer’s treatment, cognitive rehabilitation has emerged as a promising frontier. Neuroplasticity, the brain’s ability to rearrange itself by forming new neural connections, forms the basis of these therapies. Activities and exercises stimulating various regions of the brain have shown remarkable potential in slowing cognitive decline and enhancing memory retention. From puzzles and games to music therapy and art programs, these interventions provide mental stimulation and improve the general quality of life for Alzheimer’s patients. As researchers continue to resolve the complexities of the disease and innovative therapies make their way from labs to clinics, there is newfound hope for millions affected by Alzheimer’s. Families once bound by the fear of an uncertain future can now look ahead with optimism, knowing that science is steadily weaving a tapestry of solutions, each thread representing a step closer to a world without Alzheimer’s. Targeted Drug Therapies- Precision in Action The development of targeted drug therapies represents a significant milestone in Alzheimer’s treatment. These drugs are designed to interfere with specific processes involved in the development of the disease, such as inhibiting the production of beta-amyloid or regulating neurotransmitter levels. Unlike traditional treatments, which often provide temporary symptomatic relief, targeted drug therapies address the underlying mechanisms of Alzheimer’s, aiming to halt or slow down the disease’s advancement. As these drugs undergo rigorous testing and clinical trials, they offer a beacon of hope for patients and their families, promising a future where Alzheimer’s is not synonymous with helplessness. In this era of relentless scientific pursuit and unwavering determination, the promise of a breakthrough looms large. Alzheimer’s, once an enigma shrouded in despair, is now met with resilience, hope, and a commitment to transform the lives of those it touches. As we navigate the intricate paths of medical progress, one truth remains steadfast: the collective effort to revolutionize Alzheimer’s treatment is a testament to the indomitable spirit of humanity, weaving a future where memories are preserved, minds remain vibrant, and families stand united against the challenges of Alzheimer’s disease. The Role of Lifestyle Interventions- Empowering Patients -Pooja Shah Amidst the scientific advancements, the role of lifestyle interventions in Alzheimer’s treatment cannot be overstated. Research has consistently shown that adopting a healthy lifestyle, encompassing regular exercise, a balanced diet, social engagement, and mental stimulation, can 26 | October 2023 www.healthcareeverything.com

Top 5 Alzheimer's Disease Solution Providers North Star Senior Advisors Providing a Guided Path for Senior Living Ignacio Quinones President About the Leader Ignacio Quinones started his military career as an Infantry soldier in Washington DC, ‘The Old Guard’ where he participated in various key decorated ceremonies, funerals, and parades for the US armed forces. He then began his career as an Army Nurse at Walter Reed Army Medical Center where he cared for wounded soldiers post 9/11. S necessity for specialized care has become increasingly crucial to families everywhere as our population becomes older. However, achieving and sustaining optimal health and wellness for older people is more than just a medical issue. Hence, effective geriatric services have become a crucial necessity. enior parents and other ageing loved ones often require specialized medical care. The Orlando Award Program, as well as listed at number 46 on Feedspot’s Top 100 Senior Care Blogs list for Blogs, Websites and Influencers in 2021. Our mission is to offer free support and guidance through your transition into senior living. As a nurse and veteran-owned and operated firm, Ignacio continues to use his nursing license when assessing seniors to help locate senior living options that can accommodate their level of care, allowing for a proper placement. In the following interview, Ignacio Quinones, the President of North Star Senior Advisors, shares the journey of the company, its mission, and how the company is assisting senior citizens to provide a guided path for senior living. Please brief our audience about North Star Senior Advisors, its mission, and the key aspects of its stronghold within the senior care services niche. Effective geriatric care necessitates collaboration between health providers and caretakers. Both work together to manage their elders’ health concerns and provide a safe, positive environment for them. Assisted Living communities possess different license types where some can only accommodate certain needs. Having a nursing background provides seniors and families with accurate information so they can make the best, informed decision regarding their senior living needs. you choose. We recently expanded our niche and now offer Care Management services, helping you through the aging process. Established in 2014, our mission is to offer free support and guidance through your transition into senior living. We’ll explain the process, provide an overview of senior living communities, and accompany you on tours to ensure that you find that perfect new home in Lake, Seminole, Orange, Osceola, and Volusia Counties. We never charge a fee to families and are paid by the assisted living or memory care community that Tell us more about North Star’s services that give you a distinct edge to stand out from the competition? To cater to this need, senior care companies were established. One promising name in that list is North Star Senior Advisors which is highly experienced in assisting families for senior living. We provide a guided path to senior living by narrowing down options based on budget, location, level of care, and more. What makes us unique to this industry is that not only do we have 30+ years of combined North Star was selected for the 2020 Best of Orlando Award in the Assisted Living Facility category by the 28 | October 2023 www.healthcareeverything.com 29 | October 2023 www.healthcareeverything.com

healthcare/senior living experience, but all staff members are also certified dementia practitioners to assist those with Dementia/Alzheimer’s. residents were asked not to leave unless there was a medical emergency. But once their return, they had to be quarantined for 14 days. This not only impacted our business but also how we operate. Also, we have a nurse on duty to perform accurate assessments for proper placement. We are also veteran owned and have bi-lingual staff upon request. Our team is local to the Central Florida area, and we have personally toured all communities and checked to ensure they are free of abuse and negligence before guiding our seniors and families there. Normally, we meet with families for a consult and then schedule and accompany families on tours of senior living communities, but all of this came to a halt. Fortunately, we were still able to guide families throughout all of the pandemic as we conducted virtual consults and tours. When the governor announced that they were planning to open again, we were grateful to be able to provide in-person visits again. What is your opinion on the effects of the current pandemic on the healthcare sector, and what challenges did North Star Senior Advisors face during the initial phase of the pandemic? With continuous technological development in the healthcare space, what is your prediction about the future of the senior care services market? controlled artificial intelligence assistance also known as ‘Smart Homes’. The current pandemic has affected us all in some form with the healthcare sector being affected the most. What we have seen at the beginning of the pandemic was that most individuals were hesitant to place their loved ones in senior living communities, understandably. Senior Living communities will have fully integrated technology by including Telehealth services for providers in order to conduct clinical appointments to residents in senior living communities. In addition, virtual assistant devices will be added to senior living apartments, so residents can enjoy the benefits of voice As an established leader, what would be your advice to the budding entrepreneurs and enthusiasts aspiring to venture into the senior care services niche? All communities were also forced to go on lock down. So, visitors were no longer allowed inside, and current One would definitely have to have a passion for working with the geriatric population. Ideally, their product or service needs to satisfy a large demand. I would also build a large synergistic network within the healthcare sector they are choosing to work within and always find ways to give back to the community. How do you envision scaling North Star Senior Advisors’ operations and offerings in 2023? We want to continue to approve upon our core business within senior placement and grow our new care management services going into 2023 30 | October 2023 www.healthcareeverything.com

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Top 5 Alzheimer's Disease Solution Providers