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PPAR and NOX Agonist_ Savior of Underserved Primary Biliary Cholangitis Patients

Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is an autoimmune condition that causes the periportal inflammatory cholestasis that results from the slow death of intrahepatic bile ducts. Cirrhosis and portal hypertension are the results of persistent hepatic cholestasis.<br>

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PPAR and NOX Agonist_ Savior of Underserved Primary Biliary Cholangitis Patients

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  1. PPAR and NOX Agonist: Savior of Underserved Primary Biliary Cholangitis Patients Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is an autoimmune condition that causes the periportal inflammatory cholestasis that results from the slow death of intrahepatic bile ducts. Cirrhosis and portal hypertension are the results of persistent hepatic cholestasis. UDCA and OCALIVA – The Only Available Therapies for Primary Biliary Cholangitis Treatment Despite Controversies Ursodeoxycholic acid (UDCA) and obeticholic acid are the only two primary biliary cholangitis drugs that the Food and Drug Administration (FDA) has approved for treating primary biliary cholangitis (OCALIVA). UDCA is still the go-to first-line treatment for primary biliary cholangitis despite the introduction of promising second-line therapies for PBC patients who are UDCA-intolerant or UDCA-naive. The UDCA's good long-term efficacy and safety profile and affordable primary biliary cholangitis treatment are the main reasons for the sustained trust. By enhancing hepatobiliary secretory function and lowering bile toxicity, UDCA has anti-cholestatic effects. Obeticholic acid (OCA), OCALIVA was the second medication to be approved for use in patients who had an inadequate response to UDCA or were intolerant as well as those who were UDCA-naive. For 40 to 80% of people with primary biliary cholangitis, fatigue is the most often reported symptom of their condition. Fatigue has crippling physical repercussions that affect patients' capacity to accomplish everyday tasks, and it also negatively affects their mental health, social life, family life, sexual life, and work performance. Musings on the Primary Biliary Cholangitis Treatment Seladelpar, being developed by CymaBay Therapeutics, elafibranor, setanaxib, saroglitazar Mg, and linerixibat are some of the promising PBC medications to hit the primary biliary cholangitis therapy market (GlaxoSmithKline). For the management and first treatment of biliary cholangitis in the 7MM+ China, all assets are now in the late stages of development. Primary Biliary Cholangitis Treatment Market All Set to Grow Significantly The market environment will benefit from the development of disease-specific medicines for the treatment of primary biliary cholangitis, which will then enable major changes during the forecast period (2019–2032). With improved diagnosis and safe and effective primary biliary cholangitis treatment options, the market for treating this condition is anticipated to increase significantly. However, difficulties with price and reimbursement, as well as related long-term side effects of approved medications, are two key factors that affect the market success of the future therapies for the primary biliary cholangitis treatment. Related Reports

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