University at Buffalo The State University of New York

1. VAWNYHS School of Medicine & Biomed. Sciences University at Buffalo The State University of New York Buffalo-Niagara Medical Center

2. FLIESLER, Steven J, PhD: Lipid/sterol metabolism; photoreceptor membrane trafficking; animal models of retinal degenerations. • GONZALEZ-FERNANDEZ, Federico, MD, PhD: Photoreceptor - RPE interactions; vitamin A (retinoid) cycle; Interphotoreceptor matrix; structure and function of retinoid binding proteins; Xenopus and zebrafish model systems; human ocular pathology. • MU, Xiuqian, MD, PhD: Retinal development; retinal ganglion cell differentiation; gene regulatory networks; transgenic and knockout mouse models. • *PATEL, Sangita P., MD, PhD: molecular basis of corneal hydration control; corneal endothelial cell physiology: • REYNOLDS, James D., MD:Retinopathy of Prematurity (ROP)- multi-center treatment trials, CRYO-ROP, LIGHT-ROP, ET-ROP, natural history and its implications for screening. • SULLIVAN, Jack M., MD, PhD:  RNA drug discovery for retinal/macular degenerations; gene silencing/gene therapy; humanized mouse models of retinal degeneration; retinal electrophysiology.

3. BAIER, Robert E., PhD: [Oral Diagnostic Sci./Biomaterials] Interfacial biophysics; structure and function of macromolecules at biosurfaces; anterior tear film structure; biomaterials compatibility with ophthalmologic contact tissues. • GOSH, Debashis, PhD:[HWI]X-ray crystallographic studies of protein structure-function relationships • MEYER, Anne E., PhD: [Oral Diagnostic Sci./Biomaterials] Surface analysis; biomaterials; biofilms/biofouling; ophthalmologic friction and lubrication. • SEIGEL, Gail M., PhD:[Center for Hearing & Deafness] Cancer stem cells; retinoblastoma; retinal cell differentiation. [Established the R28 rat retinal precursor cell line (available for collaborative efforts)] • SLAUGHTER, Malcolm M., PhD: [Physiology & Biophysics] Information coding in retina; role of synaptic receptors in synaptic labeled lines. • TITUS, Albert H., PhD: [Electrical Engineering/Integrated Nanostructured Systems] Analog VLSI Design, Silicon-based neuromorphic visual processing systems, Neural networks, Electronic routing and packaging design, Electron beam lithography, Sensors, Optoelectronics.

4. NIH Grant Support FUNDED: • FLIESLER, SJ - NIH/NEI RO1 EY007361 Isoprenoid Metabolism in the Retina • NIH/NEI RO1 EY013623 (subaward) Proteasome Function in the Aging Retina • GONZALEZ-FERNANDEZ, F- NIH/NEI R01 EY009412 Interphotoreceptor Retinoid Binding Protein: Structure and Function • SEIGEL, GM-NIH/NEI R21 CA127061 Tumor-Initiating Cells in Retinoblastoma • NIH/NCI U54 CA143876 (subaward) Center on the Microenvironment and Metastasis • SLAUGHTER, MM- NIH/NEI R01 EY005725 Synaptic Mechanisms in Retina • NIH/NEI R24 EY016662 UB Vision Infrastructure Center PENDING: MU, X- NIH/NEI NIH/NEI RO1 EY020545 Interaction of Isl1 and Pou4f2 in Retinal Development SEIGEL, GM- NIH R01 CA138230 (Subaward) Immune Targeting of Tumor Stem Cells in Retinoblastoma SULLIVAN, JM- NIH/NEI R01 EY13433 A Ribozyme Rescue Strategy for Autosomal Dominant Retinitis Pigmentosa

5. New York State Center of Excellence in Bioinformatics & Life Sciences  (CoE) Hauptman-Woodard Medical Research Institute (HWI)

6. Roswell Park Cancer Institute (RPCI) http://www.roswellpark.org/Home • UB Center for Advanced Biomedical and Bioengineering Technology (UBCAT) http://www.bioinformatics.buffalo.edu/cat.php • UB2020 Integrated Nanostructured Systemshttp://ub2020.buffalo.edu/ins/

7. Potential R24/Collaborative Projects *RNA Drug Discovery for Ocular Diseases [J. Sullivan, P. Reinach, J. Danias, M. Srinivas, and others] *Stem Cell Therapy for Glaucoma [X. Mu, J. Danias, G. Seigel, and others] Structural Biology and Molecular Modeling [F. Gonzalez-Fernandez, D. Gosh, and others] Animal Models of Dysregulated Metabolism [S.J. Fliesler, B. Knox, J. Danias, and others] * More immediate therapeutic development potential