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Publication of all aspects of the scientific process: Open Source Science / Open ... Third Party Time-Stamp on Experiment Versions. Monitoring experimental ...
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Open Notebook Science: Research in Real Time Sigma Xi Swarthmore College Chapter Jean-Claude Bradley E-Learning Coordinator College of Arts and Sciences Associate Professor of Chemistry Drexel University Nov 27, 2007
Open and Closed Science Open Notebook Science (full transparency) Traditional Lab Notebook (unpublished) Traditional Journal Article Open Access Journal Article RESEARCH OPEN CLOSED TEACHING Archived Lectures Public and free online textbooks Lectures Notes public Traditional Paper Textbook F2F lectures Assigned problems public
Where is Science headed? WE ARE HERE
How will this happen? • Self-organizing redundant processes • Fully Open Access (Read and Write) • Publication of all aspects of the scientific process: Open Source Science / Open Notebook Science • Using semantically rich formats and automation at zero publication cost – is this the way to the technological singularity?
How can machines know what is important? Ask the humans
Malaria is a Logical Application of Open Science • Very large problem: 300-500 million cases per year with one million deaths • Not a lucrative market: IP control less important
Diketopiperazine Library First iteration: Solid Support Synthesis Evolves to: on pot Ugi reaction/cyclization
The blog as an integrative tool usefulchem.blogspot.com
Graphical Mining of Data with JSpecView usefulchem.wikispaces.com/Exp070 (48h 7 min)
Student assignment on NMR using live research data and JSpecView
Open Primary Research in Drug Design using Web2.0 tools(blogs, wikis, Second Life, mailing lists) Rajarshi Guha Indiana U Tsu-Soo Tan Nanyang Inst. Docking JC Bradley Drexel U Synthesis Phil Rosenthal UCSF (malaria) Dan Zaharevitz NCI (tumors) Testing
Open science connectivity More info on open source science here http://usefulchem.wikispaces.com
Falcipain-2 inhibitor? Khalid Mirza http://usefulchem.wikispaces.com/Exp148
Raw Experimental Data neurodatabase.org
Selected Experiments (some failed) Orgprepdaily.wordpress.com
Generalized Protocols Openwetware.org
Vendor Reliability Orgprepdaily.wordpress.com
Lab Notebook for intra-group communication Openwetware.org
Discussing Hypotheses RRResearch.blogspot.com
UsefulChem and Open Science in Second Life scifooliveson.wikispaces.com
Question: Is it really a good thing to let anyone who thinks they have a scientific breakthrough have access to free, open, public, Googleable media? • YES • Question: What if I make a mistake in my data, never fix it, no one catches it, and then someone dies because a medical decision was based on my "findings"? Isn't this exactly why we have formal peer review in formal publications? • Peer review is not designed to catch errors from the analysis of raw data • Open Notebook Science is more difficult where human subjects are involved • Question: Who is the audience for science blogs and wikis anyway? Scientists or laypeople? • For UsefulChem, wiki is for chemists, blog for wider audience • Question: Can you get published if you've already posted your results to your blog/wiki? • We’ll find out…. • Question: Can scientists establish their credibility/reputation by writing blogs and wikis? • Certainly we’ve found collaborators this way