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History. Animal Papillomaviruses were first identified in the early 20th century. Studies showed skin warts or papillomas could be transmitted between individuals by a filterable infectious agent. In 1935 Francis Peyton Rous, previously demonstrating the existence of a cancer-causing sarcoma virus in chickens, went on to prove papilloma virus could cause skin cancer in infected rabbits. This condition may have led to the infamous
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