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2002 Protocol Updates. Phenergan (Promethazine)Anti-nauseant, enhance narcoticNorcuron (Vecuronium)Long acting paralyticVersed (Midazolam)Anticonvulsant, CNS depressant, amnestic. Phenergan (Promethazine). Phenothiazine derivativeEffectsH1 receptor antagonistAntiemeticSedating agentAnticholinergic effectsIndicationsAntiemeticPotentiate narcotics.
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1. January 2002 Protocol Updates Lynn K. Wittwer, MD, MPD
Clark County EMS
2. 2002 Protocol Updates Phenergan (Promethazine)
Anti-nauseant, enhance narcotic
Norcuron (Vecuronium)
Long acting paralytic
Versed (Midazolam)
Anticonvulsant, CNS depressant, amnestic
3. Phenergan (Promethazine) Phenothiazine derivative
Effects
H1 receptor antagonist
Antiemetic
Sedating agent
Anticholinergic effects
Indications
Antiemetic
Potentiate narcotics
4. Phenergan (Promethazine) Side effects
CNS depression
EPS
Arteriospasm (if inadvertent arterial injection)
Vascular irritation
May lower seizure threshold
Not recommended for patients less than 2 years
Not to be given SC.
May cause temporary sexual dysfunction
5. Phenergan (Promethazine) Administration/Dosage
Can be given deep IM or IV
Dose is 12.5 – 25 mg (1/2 – 1 cc)
Use lower dose for IV administration.
Follow IV dose with fluid flush to prevent local irritation
Peds dose (2-12 years) ˝ adult dose
6. Norcuron (Vecuronium) Pharmacology
Non-depolarizing neuromuscular blocker
Competes for cholinergic receptor sites
Indications
Identified need for long term paralysis
Patient INTUBATED and arousing and/or combative
Risk of losing patent airway
Continued transport time
7. Norcuron (Vecuronium) Contraindications
Known hypersensitivity
Initial induction agent
Use as a sedative
Side Effects
Looooooonnnnngggg term paralysis in Myasthenia Gravis
Malignant hyperthermia (book says so)
8. Norcuron (Vecuronium) Administration/Dosage
0.1mg/kg IV bolus
Ensure adequate oxygenation/ventilation
Capnography mandated
Patient clinical response
Provide necessary sedation per protocol
Valium/Versed
Notify receiving physician of long-term paralytic use
9. Versed (Midazolam) Pharmacology
Benzodiazepine, short acting
CNS depressant, anticonvulsant, amnestic
Indications
Seizures
Sedating agent for TCP, Cardioversion, RSI, long term paralytic use
Stimulant OD
10. Versed (Midazolam) Side Effects
Respiratory depression
Hypotension
Ataxia
Administration/Dosage
2.5 – 5mg IV/IM Max 10 mg
Peds dose 0.1mg/kg IV, 0.2mg/kg IM,IO