2.2 Pharmacokinetics Drug metabolism

May 31, 2018

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2.2 Pharmacokinetics Drug metabolism

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Drug Metabolism

Drug Metabolism. S.P. Markey Laboratory of Neurotoxicology NIMH, NIH. Nov. 16, 2006. Evolution of Drug Metabolism As a Science Post WWII Pioneers. Richard Tecwyn Williams – Great Britain

1.47k views • 47 slides

Drug Metabolism

Drug Metabolism. S.P. Markey Laboratory of Neurotoxicology NIMH, NIH. Nov. 1, 2007. Evolution of Drug Metabolism As a Science Post WWII Pioneers. Richard Tecwyn Williams – Great Britain

639 views • 48 slides

Drug Metabolism and Pharmacokinetics Core

Drug Metabolism and Pharmacokinetics Core. Goal: To provide comprehensive pharmacology support for preclinical and clinical research. Services:. Pharmacokinetic studies: Quantify drug levels in serum/plasma, tissue or cells

621 views • 16 slides

Pharmacokinetics (Drug disposition)

Pharmacokinetics (Drug disposition). Mental picture of what’s really happening inside…. General Rules. Pharmacokinetics is about processes How things WORK We can only sample from the blood stream. We describe what happens to the MASS (the whole dose) of drug we’ve given.

1k views • 33 slides

Drug Metabolism

Drug Metabolism. Most metabolic products are less pharmacologically active Important exceptions : Where the metabolite is more active (Prodrugs, e.g. Erythromycin-succinate (less irritation of GI) --> Erythromycin) Where the metabolite is toxic (acetaminophen)

911 views • 29 slides

Predicting Human Drug Metabolism and Pharmacokinetics in Drug Discovery

Predicting Human Drug Metabolism and Pharmacokinetics in Drug Discovery. Carl D. Davis, Ph.D. April 17 th 2007 Drug Metabolism and Pharmacokinetics Pharmaceutical Candidate Optimization Bristol-Myers Squibb Company. carl.davis@bms.com. Agenda.

1.64k views • 36 slides

Pharmacokinetics: Drug Excretion

Topic 5. Pharmacokinetics: Drug Excretion. 713 311 PRINCIPLES OF VETERINARY PHARMACOLOGY Dr. Korawuth Punareewattana . Faculty of Veterinary Medicine, Khon Kaen University. Topic Contents. Definition Routes of excretion Renal excretion Processes involved in renal excretion Ion trapping

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Pharmaceutical analysis Bioavailability studies Drug metabolism studies, pharmacokinetics Characterization of potential

Applications of Mass Spectrometry. Pharmaceutical analysis Bioavailability studies Drug metabolism studies, pharmacokinetics Characterization of potential drugs Drug degradation product analysis Screening of drug candidates Identifying drug targets Biomolecule characterization

573 views • 7 slides

Drug metabolism

Drug metabolism. Refers to enzyme-mediated biotransformations (detoxication) that alter the pharmacological activity of both endogenous and exogenous compounds. . Drug metabolism.

2.3k views • 48 slides

Drug Metabolism

Drug Metabolism. Where? First-Pass Effect More than 1 metabolite! Varies depending on species, age, gender, genetic variation, disease. Phase I Oxidations Reductions Hydrolysis. Phase II Synthetic/Conjugation. Phases of Drug Metabolism. Phase I Oxidations.

563 views • 27 slides

Drug elimination ( metabolism , excretion)

Drug elimination ( metabolism , excretion). Anton Kohút. DRUG METABOLISM major site of drug metabolism – liver , exceptions: - suxamethonium and procaine - plasma cholinesterase - tyramine - intestinal wall. Phase 1

1.8k views • 52 slides

Understanding Pharmacokinetics & Drug-Drug Interactions

Understanding Pharmacokinetics & Drug-Drug Interactions. HIV Research Catalyst Forum April 2010 Kimberly Struble, PharmD FDA Tracy Swan, Treatment Action Group. TODAY’S TOPICS What is pharmacokinetics? What is a drug-drug interaction? Examples

878 views • 29 slides

Ethanol Pharmacokinetics, Metabolism and Forensic Aspects

Ethanol Pharmacokinetics, Metabolism and Forensic Aspects. The goal of this lecture is to describe the biochemical pathways which play a role in the metabolism of ethanol.

729 views • 30 slides

Drug Metabolism

Drug Metabolism. Clinical Biochemistry 2003 Nigel Atkinson n.p.atkinson@tees.ac.uk. Topics Fate of drugs in the body Biological Oxidations The Role of the Hepatic MES Drug metabolism reactions Metabolism of Paracetamol Metabolism of Alcohol Metabolism of Methanol. Definitions Drugs

1.44k views • 49 slides

Drug metabolism

Drug metabolism. Dr.S.O. Ogundele. Introduction. Drug metabolism is a process transforming drugs to a more water soluble metabolite within the body Most drugs are hydrophobic Drug metabolism results in the following Prevention of accumulation of drug within the body

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What is the Role of Drug Metabolism and Pharmacokinetics (DMPK) in Drug Discovery

In drug discovery and development, we utilize Drug Metabolism and Pharmacokinetic (DMPK) studies for the assessment of bioavailability, half-life, metabolic properties, and clearance profile of a given drug compound.

129 views • 7 slides

Pharmacokinetics of Drug Absorption

Pharmacokinetics of Drug Absorption. Dr Mohammad Issa. Absorption phase: absorption rate more than elimination rate Postabsorption phase: elimination rate more than absorption rate Elimination phase: no significant absorption occur (only elimination process). Oral absorption.

689 views • 41 slides

Drug Metabolism

967 views • 29 slides

Predicting Human Drug Metabolism and Pharmacokinetics in Drug Discovery

404 views • 36 slides

Pharmacokinetics of Drug Absorption

Pharmacokinetics of Drug Absorption. Absorption phase: absorption rate more than elimination rate Postabsorption phase: elimination rate more than absorption rate Elimination phase: no significant absorption occur (only elimination process). Oral absorption.

557 views • 41 slides

Drug Metabolism and Pharmacokinetics (DMPK)

DiponEd provides comprehensive, cost-effective Drug Metabolism and Pharmacokinetics studies u2013 DMPK Studies support across the drug discovery paradigm for evaluating and optimizing the drug-like properties of new chemical entities and bioanalytical/pharmacokinetic studies that span all stages of drug discovery, Exploratory studies, Hit-to-lead, Lead optimization and Candidate selection, Preclinical IND-enabling studies. So, leverage on our ADME/DMPK services that help you make informed decisions. To know more visit :-https://www.diponed.com/contact-us/

321 views • 1 slides

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2.2 Pharmacokinetics Drug metabolism

2.2 Pharmacokinetics Drug metabolism

Presentation Transcript

Drug Metabolism

Drug Metabolism

Drug Metabolism and Pharmacokinetics Core

Pharmacokinetics (Drug disposition)

Drug Metabolism

Predicting Human Drug Metabolism and Pharmacokinetics in Drug Discovery

Pharmacokinetics: Drug Excretion

Pharmaceutical analysis Bioavailability studies Drug metabolism studies, pharmacokinetics Characterization of potential

Drug metabolism

Drug Metabolism

Drug elimination ( metabolism , excretion)

Understanding Pharmacokinetics &amp; Drug-Drug Interactions

Ethanol Pharmacokinetics, Metabolism and Forensic Aspects

Drug Metabolism

Drug metabolism

What is the Role of Drug Metabolism and Pharmacokinetics (DMPK) in Drug Discovery

Pharmacokinetics of Drug Absorption

Drug Metabolism

Predicting Human Drug Metabolism and Pharmacokinetics in Drug Discovery

Pharmacokinetics of Drug Absorption

Drug Metabolism and Pharmacokinetics (DMPK)

Understanding Pharmacokinetics & Drug-Drug Interactions