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Pharmaceutical analysis Bioavailability studies Drug metabolism studies, pharmacokinetics Characterization of potential

Applications of Mass Spectrometry. Pharmaceutical analysis Bioavailability studies Drug metabolism studies, pharmacokinetics Characterization of potential drugs Drug degradation product analysis Screening of drug candidates Identifying drug targets Biomolecule characterization

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Pharmaceutical analysis Bioavailability studies Drug metabolism studies, pharmacokinetics Characterization of potential

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  1. Applications of Mass Spectrometry • Pharmaceutical analysis • Bioavailability studies • Drug metabolism studies, pharmacokinetics • Characterization of potential drugs • Drug degradation product analysis • Screening of drug candidates • Identifying drug targets • Biomolecule characterization • Proteins and peptides • Oligonucleotides • Environmental analysis • Pesticides on foods • Soil and groundwater contamination • Forensic analysis/clinical

  2. What does a mass spectrometer do? 1. It measures mass better than any other technique. 2. It can give information about chemical structures. What are mass measurements good for? To identify, verify, and quantitate: metabolites, recombinant proteins, proteins isolated from natural sources, oligonucleotides, drug candidates, peptides, synthetic organic chemicals, polymers

  3. Ion source:makes ions How does a mass spectrometer work? Sample Mass analyzer: separates ions Mass spectrum:presents information

  4. Mass Spectrometer Block Diagram High Vacuum System Ion source Mass Analyzer Data System Inlet Detector

  5. Background • Mass spectrometry (Mass Spec or MS) uses high energy electrons to break a molecule into fragments. • Separation and analysis of the fragments provides information about: • Molecular weight • Structure

  6. http://www.youtube.com/watch?v=mBT73Pesiog

  7. ISOTOPES Thallium has two stable isotopes, 203-Tl and 205-Tl. Knowing that the atomic weight of Thallium is 204.4, which isotope is the more abundant of the two?

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