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Nodax Polyhydroxyalkanoate

Vaccine - 4/11/06. 2. POLYHYDROXYALKANOATE COPOLYMERPOLYHYDROXY BUTYRATE

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Nodax Polyhydroxyalkanoate

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    1. Vaccine - 4/11/06 1 Nodax™ Polyhydroxyalkanoate Development of a Low Cost Fermentation and Recovery Process for a Commodity Polymer Phillip Green Karuna Narasimhan Procter & Gamble Co.

    2. Vaccine - 4/11/06 2

    3. Vaccine - 4/11/06 3 Properties of Interest Biological - Made from renewable sources - Aerobically and An-aerobically biodegradable   Thermo –Mechanical - Similar to polyethylene and polypropylene - Strength, flexibility, toughness - Exhibit (Springy) Elasticity Physio-Chemical - Higher surface energy – Dyeability, printability - Chemical digestibility in hot-alkaline medium - Barrier properties

    4. Vaccine - 4/11/06 4 PHA Process Summary

    5. Vaccine - 4/11/06 5 Technical Development Overview What is needed technically to reach commercialization? Yield: organism and fermentation protocol that delivers target composition and yield at large scale. Cost effective and reliable recovery process. Nucleation package to enable finished article processing. Long term Making Cost Target = < $2.30/kg

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    11. Vaccine - 4/11/06 11 PHA Recovery Process Transformations Lysing of Cell – By - Mechanical/Chemical digestion/Enzymatic - Solvents Dissolving PHA in solvents at moderate Temp., high levels Separation of cell debris from PHA Precipitating PHA - modifying the solubility by - Temperature and/or - “Non-Solvents” Separation of PHA from liquid media. Possible Combinations- - LSS- Clean up of unwanted material Biomass - DSPS- Extracting good polymer from Biomass

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    14. Vaccine - 4/11/06 14 Aqueous Isolation Process Concept

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    16. Vaccine - 4/11/06 16 Solvent Extracted Product Composition (Mol % Co-polymer content) MW ( < 20% reduction in MW) DSC (Melting temp.- Target 100-150 0C, matching copolymer content) Purity (> 99-100%) Color (L- > 95, a < +/- 2, b < +/- 4) Odor (no offensive odor) Residual Solvents (typical < 200 ppm Vs. target < 1000 ppm)

    17. Vaccine - 4/11/06 17 Questions ? Thank You .

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