Protein Function Diversity: An Introduction

Apr 14, 2013

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Protein Function

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Protein Function Diversity: An Introduction

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Protein Function

Protein Function. Globins and Antibodies 3/10/2003. Hemoglobin and Myoglobin. Because of its red color, the red blood pigment has been of interest since antiquity. First protein to be crystallized - 1849. First protein to have its mass accurately measured.

982 views • 46 slides

Modeling Protein Function

Modeling Protein Function. MED260 Philip E. Bourne Department of Pharmacology, UCSD pbourne@ucsd.edu http://www.sdsc.edu/pb Slides on-line at: http://www.sdsc.edu/pb/edu/med260/med260.ppt. Agenda. Why model protein function? Where does it fit as a technique in modern medical research?

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Protein Function

Protein Function. Structure will determine the function of the protein. Key ideas and terms. protein can bind a ligand in the binding site For an enzyme, the ligand is a substrate and they bind in what is called the active site ligand has to be the correct shape

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An Introduction to Animal Diversity

An Introduction to Animal Diversity. What Is an Animal? An Overview of Animal Phylogeny and Diversity The Origins of Animal Diversity. What Is an Animal?.

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An Introduction to Animal Diversity

An Introduction to Animal Diversity. Chapter 32. Characteristics of Animals. Multi-cellular Heterotrophic eukaryotes - ingestion Lack cell walls – collagen Tissues that develop from embryonic layers Most have nervous & muscular tissue Most reproduce sexually Flagellated sperm Large egg

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Introduction to Rangeland Insects: Diversity and Function

Introduction to Rangeland Insects: Diversity and Function. Steve Cook Department of Plant, Soil and Entomological Science University of Idaho. 1 October 2012. My Prejudice: I am an Entomologist: All of this other stuff is simply for growing insects – and it is not very good for that.

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Function and diversity

Function and diversity. The Portfoilio effect Statistical averaging. David Tilman (1949-. Michel Loreau. If species act indepe n dent the coefficient of variation of aggregate ecosystem properties is expected to decrease to the root of species richness.

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Protein Structure/Function

Protein Structure/Function. C483 Spring 2013. 1. Proteins segments which fold first can promote the folding of other sections of the protein into the native conformation by a process known as A ) renaturation . B ) stabilization. C ) hydrophobic interaction.

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Protein Function

Protein Function. Myoglobin and Hemoglobin. O 2 Binding and Allosteric Properties of Hemoglobin. Hemoglobin binds and transports H + , O 2 and CO 2 in an allosteric manner

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Protein Kinase Structure and Function Introduction

Protein Kinase Structure and Function Introduction  500 protein kinases encoded in the human genome  1.5 % of our genetic diversity Protein kinases regulate at some level almost all cellular processes. Cellular proliferation Cell cycle Replication Translation …..

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Protein Function –Binding

Protein Function –Binding. Chapter 5:. Function of Globular Proteins: Ligand Binding. Learning Goals. 1. Reversible binding of ligands is essential Specificity of ligands and binding sites Ligand binding is often coupled to conformational changes, sometimes quite dramatic (Induced Fit)

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Protein function

C. E. N. T. E. R. F. O. R. I. N. T. E. G. R. A. T. I. V. E. B. I. O. I. N. F. O. R. M. A. T. I. C. S. V. U. Lecture 17:. Protein function. Introduction to Bioinformatics. Domain fusion.

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An introduction to animal diversity

An introduction to animal diversity. BY Carlos Paez. OVERWIEW. WE WILL BE LEARNING ABOUT THE ANIMAL KINGDOM THAT GOES BEYOND HUMANS AND WE WILL ALSO LEARN ABOUT ANIMAL DIVERSITY WHICH IS THE DIFFERENCE OR VARIETY OF ANIMALS. NUTRITIONAL MODE.

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Protein Function

Protein Function. Protoporphyrin. Heme. Spacefill representation of heme. Iron in Mb-bound heme can not be oxidized. Myoglobin. Ligand binding to heme. Mb increases the selectivity of O 2 binding. Ligand binding equilibrium. O 2 binding by Mb. Hb subunits are homologous to Mb.

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Protein Function

Protein Function. Andy Howard Introductory Biochemistry, Fall 2008 11 September 2008. Zymogens and Post-translational modification Allostery Specific protein functions Structural proteins Enzymes Electron transport. Specific functions (continued) Storage & transport Proteins

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Protein Function

Protein Function. Hemoglobin as a model systems for: Ligand binding Quaternary structure and symmetry Cooperative behavior Allosteric conformational effects Genetic variation, selection, disease. Myoglobin (a monomeric form of hemoglobin).

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Protein Function

Protein Function. Quaternary structure of deoxy- and oxyhemoglobin. R-state. T-state. D-2,3-bisphosphoglycerate (BPG). BPD binds to hemoglobin and decreases the oxygen affinity and keeps it in the deoxy form. BPG binds 1:1 with a K=1x10 -5 M to the deoxy form but weakly to the oxy form.

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An Introduction to Animal Diversity

An Introduction to Animal Diversity. Chapter 32. What is an Animal?. Multicellular heterotrophs Tissues develop from embryonic layers Ingest their food Lack cell walls Structural proteins called collagen Contain muscle cells and nerve cells

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Protein Function

Protein Function. A molecular bound reversibly by a protein is called a ligand . A ligand binds at a site on the protein called the binding site, which is complementary to the ligand in size, shape, charge and hydrophobic or hydrophilic character.

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Protein Function Prediction

Protein Function Prediction. Function categories of proteins : Proteins can be divided into 3 categories 1- Biochemical functions. 2- Sub cellular locations. 3- Cell role. Sub cellular locations. 1- Cytoplasm 2- Nuclear 3- Mitochondria 4- Extra cellular 5- Golgi apparatus

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An Introduction for Protein biotinylation

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Function of Protein

Function of Protein. Introduction Oxygen bind to prosthetic group Myoglobin Protein/ligand interaction Oxygen transportation Hemoglobin R&T state Cooperative bind Transport of H + /CO 2 BPG Sickle-cell anemia Immunosystem. Transport Regulatory Motor Fibrous Protein Enzyme

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