Swedish Biotech Industry & CONNECT Sweden Orjan Isacson, CEO, CONNECT Sweden BioSpain2004, November 29-30, 2004

1. Swedish Biotech Industry & CONNECT Sweden Orjan Isacson, CEO, CONNECT Sweden BioSpain2004, November 29-30, 2004

2. Swedish Biotech Clusters

3. Brand names of global recognition • Karolinska Institutet • The Nobel Price

4. The largest biotech industries in EuropeNumber of companies Note: Figures apply to December 2000. Source: European Commission, “Innovation and competitiveness in European biotechnology”, 2002

5. Preclinical development Target validation Swedish biotech firms active throughout entire value chain Target identification Clinical development

6. Examples of unique Swedish databases • In-patient care register • Generation register • Swedish twin register • Extensive documentation of bipolar patients • Hubin database (schizophrenia) • Cancer register • Tissue databanks

7. Employment fulltime private sector, 2003 Biotech 5,000 Turnover private sector, 2002 (EUR m) Biotech 1,000 Research & development private sector, 2001 (R&D spending/turnover) Biotech 17.1% Largest life science companies in Sweden, 2003 AstraZeneca (UK) Pfizer (US) Amersham Biosciences (UK) Gambro (Swedish) Fresenius Kabi (Germany) Swedish biotech industry - key statistics Source: Statistics Sweden and ISA, 2004

8. High expenditure on R&D2002, percent of GDP Source: IMD, 2004

9. …..but despite having: • one of the highest R&D expenditures per capita in the world • most new patent applications per capita in the world • the highest number of scientific publications per capita • Sweden has not been creating many new high-tech • companies during the last 30 years • That is why CONNECT in Sweden was started in 1998

10. Mission To link entrepreneurs with the financial, technical and business development resources they need in order to create and develop knowledge-based companies.

11. CONCEPT FOR CONNECT Researchers/ Innovators Organizations Entrepreneurs Entrepreneurs CONNECT Venture Capital Service Providers Industrial Companies

12. CONNECT ACTIVITIES FOR GROWTH LIFE CYCLE STAGE Maturity Take-off Financial Forum Partnership Forum Success Business Angel Networks Accelerator BootCamp Survival Springboard Start FUNDING STAGE Seed Start-up Expansion Pre-start S2B Publications PUBs, Networking Meetings Courses, Seminars Best Spin-out Company from Universities

13. NUMBER OF START-UP COMPANIES 1200 Accumulated Vision (1998) 592 431 280 116 0 18 1998 1999 2000 2001 2002 2003 2008 Year

14. CONNECT SWEDEN’S FIRST 6 YEARS • Regional networks 8 • Regional offices 21 • Member companies 567 • Experienced people in the networks 2300 • Springboards (start-ups packaged) 592 • Financial Forums 11 (248 companies) • Biomedical Partnership Forums 4 (118 companies) • Publications for Entrepreneurs 13

15. FINANCING The CONNECT networks in Sweden are mainly financed by fees for memberships and certain activities and by sponsoring. CONNECT Sweden, the umbrella organization, is financed by the Swedish Industrial Development Fund and the Confederation of Swedish Enterprise. No Government money involved.

16. RESULT FROM SPRINGBOARDS • A total of 592 springboards have been completed at the end • of 2003. Result: • Startups which have received seed money: 225 (38%) • (within one year) • Total amount of capital received: € 113 million • Number of new employees: 1080

17. RESULT FROM FORUMS Financial Forums Number of Swedish companies – 207 Raised capital - €304 million Biomedical Partnership Forums Number of Swedish companies – 75 Raised capital - €196 million

18. CONNECT Nordic CONNECT Sweden (21 locations) CONNECT Norway (5 locations) CONNECT Estonia (2 locations) CONNECT Latvia CONNECT Denmark (4 locations)

19. A few CONNECT companies…. Cella Vision Buyonet Dressmart Prosta Lund Prover Technology Softline Svenska Test YoYo Technologies ZoomOn Cureon Probi Absorber, XCounter Bioinvent Angio Genetics Asta Carotine Bacterium Melacure NeoPharma Sidec UmanGenomics Avancee NeruNova Biolight D-Flow Energy Optikon Hapax Integrum Intermezzon LightUp Technologies Multisoft Nanofactory Textile Solutions Unicorn Got-A-Gene Lifline C Vision Sinova Grozer Shopsense Expoplnet Chemel Prolight Agaton Fitness Tully’s Coffee Swats Skolboken Fogo ToyCity Fodum Senaten Active Care Clinitrac Clinical data Care On Position Alpha Helix Anamar Medical CynerGene AgriSera BioGaía BioPhasia Carlsson Research Global Genomics Personal Chemistry Q-Sense Tripep Vitrolofe Mando Brevas Spotfire Surgical Science Innoventus Funplanet Addsystems Lazybee Crest Computer Spectral DiscMap ProTender MsFreckles Stedman Dev. Per Mail SpaceMetrics Gohandy Bluice Research Satsafe Elink Right Position Solid Entertainment Sifira Castella Media Addnature Tourism Planet ICE International Tacton Carasoft Catasis INID Bluesolid Comperio SnapSend Erri Startloop Ullmann Communications Consumer Response Partitur Celgen Solutions Boldsoft Silicide Feubic Avaris Combio Accuro Immunolgy AngioGenetics MIP Technologies Spectrum Medical Sciences Eutech Medical Micromuscle Sophion Innate Pharmaceuticals Heptahelix Aditus Medical Athera Biotech Cambrex Arexis Biolipox Curonia Research AbSorber Karocell Tissue Engineering Calluna Xenerate Cartella Alligator Bioscience Genovis Bioett Tacton Optimobile Erysave Synergenix Interactive Speedpart Aquaily OptiQ Radarteam Sweden Morphic Technologies Add-X Biotech Ludesi Telenvironment Agency9 Sparetime Zeeme Spiro Knut Cobolt LensWay Viking Helicopter Printon NetOptic Fluido WoodONet Proligo Glucox Lipocore Holdings MCe Med Orexo Angiometer Hansa Medical Comfortzone Kronan Trademark Linus MedCoat NordNav Technologies Mitrion Ray Therapy Scandinavia Sensimor SMM Medical Gatorhole Oncopeptides Cobolt Bio-Innovation EasyChange Micropos Medical Midorion Biotech Systems Nanoxis Oiido Parans Daylight Pho2link Tendera Vasasensor LipoPeptide GasOptics Sweden SLX Hydralics CoolTool Micolo MceMed Vehco BioArtic Neuroscience Ludesi Alfasensor Decuma

20. www.connectsverige.se