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Management of psoriasis with Aloe vera extract in hydrophilic cream: a placebo-controlled, double-blind study

Management of psoriasis with Aloe vera extract in hydrophilic cream: a placebo-controlled, double-blind study. Syed, Tanweer A. et al. 1996. Tropical Medicine and Internal Health 1:505-509 Presented by: Wislaine Coby. PURPOSE.

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Management of psoriasis with Aloe vera extract in hydrophilic cream: a placebo-controlled, double-blind study

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  1. Management of psoriasis with Aloe vera extract in hydrophilic cream: a placebo-controlled, double-blind study Syed, Tanweer A. et al. 1996. Tropical Medicine and Internal Health 1:505-509 Presented by: Wislaine Coby

  2. PURPOSE • To test an aloe vera extract 0.5% in a hydrophilic cream on patients with a skin disease called psoriasis compared to other medications.

  3. RECAP • What is psoriasis? A common skin disease that affects millions of children and adults, more common in Caucasians. It’s characterized by thick, dry scales and inflammation of the skin .

  4. Aloe vera • It is a cactus-like succulent perennial with long, grayish-green, prickly edge leaves. • Aloe has anti-inflammatory, anti-bacterial, and anti-fungal properties. • It heals and help ease the discomfort of minor skin irritations and burns.

  5. Active Agent • Salicylates: a pain reliever and anti-inflammatory • Magnesium lactate: inhibits the irration

  6. METHODS AND MATERIALS • 36 males and 24 females ranging from the age of 18-50 having mild to moderate psoriasis for at least 8 years. (30 patients will be treated with the aloe vera and the other 30 will be treated with a placebo) • Aloe vera extract (0.5%) in a hydrophilic cream with a combination of mineral oil and castor oil. • A double-blind, placebo control study With this study patients do not know if they have been given the active drug or the placebo. Also physicians observing also do not know.

  7. Active treatment done only for 4 weeks. • Patients had to apply the cream 3 times daily for five consecutive days, Monday through Friday excluding Saturday and Sunday. • Each patient received a 100 g tube of the treatment which had to remain at a constant temperature.

  8. Follow-ups • After the four week treatment, patients were examined once a week for 16 weeks. • Then they were followed up on a monthly basis for 8 months.

  9. RATIONALE • Lots of follow ups had to be done to observe any improvements or the severity of the medications

  10. RESULTS • All 60 patients stayed in the study, none withdrew. • A reduction of desquamation, peeling of the top layer skin. • Over all, 27/60 patients were showed improvement.

  11. 356/762 plaques on the body were cured. • There was a low PASI score (psoriasis area and severity index), showing a mean of 9.3 to 2.2. • No hypersensitivity or drug related adverse symptoms.

  12. Patients’ Characteristics

  13. Effectiveness of the aloe extract • The extract was absorbed into the dermal and tissues area of the skin. • Kept the skin moist and inhibited the plaques by suppressing proliferation and stimulatory differentiation of the cells.

  14. Comparing the aloe form the previous experiment with calcipotriol • Calcipotriol is a synthetic vitamin D analogue (most commonly used). • It induces terminal epidermal differentiation and inhibits epidermal proliferation.

  15. Experiment done • There was a total of 50 patients used for the study. • 30 patients in the 4 week trial and 20 in the 6 week trial. • Different concentrations (potent to very potent) of calcipotriol was used daily.

  16. RESULTS • In the 4 week trial with the 30 patients, 88% were cured, but some developed side effects and with drew from the study • In the 6 week trial with the 20 patients, 85% were cured but 2 patients developed adverse effects.

  17. RATIONALE • Patients treated with the calcipotriol (vitamin D analogue) did show some improvements but they were a few who developed more lesions and irritations. • This makes calcipotriol not the best treatment for everyone to use.

  18. CONCLUSION • The aloe vera extract 0.5% in hydrophilic cream was very effective and tolerable. Patients in the study developed no side effects, adverse symptoms or withdrawals. • The placebo was not effective because the patients showed no changes. • Calcipotriol was not effective because there were side effects and withdraws with this treatment.

  19. Aloe vera 0.5% in a hydrophilic cream will be the new medication to treat psoriasis. • Patients suffering from this disease will live a better life.

  20. REFERENCES • Scheer, James F. 1998. Aloe: A summer must-have & so much more. Better Nutrition 60:50-52. • Stern, Robert. 1997. Psoriasis. The Lancet 350:349-353. • Syed, Tanweer A. et al. 1996. Management of psoriasis with Aloe vera extract in hydrophilic cream: a placebo-controlled, double-blind study. Trop Med Int Health 1:505-509

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