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Jakavi 5mg belongs to the type of targeted therapy. It is an oral receptor tyrosine kinase inhibitor. It acts by inhibiting certain enzymes in the body which affect blood cell production
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RUXOLITINIB JAKAVI 5MG
DESCRIPTION INDICATIONS Jakavi 5mg belongs to the type of targeted therapy. It is an oral receptor tyrosine kinase inhibitor. It acts by inhibiting certain enzymes in the body which affect blood cell production. Jakavi 5mg is prescription drug provided under supervision of doctors or pharmacists • Jakavi 5mg is indicated for the treatment in patients with intermediate and high-risk myelofibrosis.
MECHANISM • Ruxolitinib is also knowns kinase inhibitor which is discriminating for the Janus analogue Kinases (JAK) 1 and 2. These kinases are required for the mediation of cytokine and growth factor signalling which in turn effect immune function and hematopoiesis. • The communicate process involves signal transducers and transcription activators (STAT) that modulate gene expression. Patients having myelofibrosis consist of abnormal JAK1 and JAK2 activity,ThereforeRuxolitinibfunction to regulate this.
DRUG INTERACTION • STORAGE Concomitant use with fluconazole doses greater than 200mg daily may increase Ruxolitinib exposure leads to increase the risks of exposure related adverse reaction. Interaction of Jakavi 5mg with strong CYP3A4 inhibitors will increases Ruxolitinib exposure. Interaction of Jakavi 5mg with strong CYP3A4 inducers will decreases Ruxolitinib exposure. • Jakavi 5mg stored at 20° to 25° • Protect away from light and moisture • Dispense in its original container
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