1 / 34

Pediatric Case ManagementBy Richard Lirio

Hodgkin lymphoma can be cured with radiation therapy, chemotherapy, or a ... Standard treatment regimens for pediatric Hodgkin lymphoma are as follows: ...

Roberta
Download Presentation

Pediatric Case ManagementBy Richard Lirio

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


    Slide 1:Pediatric Case Management By Richard Lirio,MD 16th June 2010

    Slide 2:History

    14 y/o Caucasian Female h/o seizure disorder, autism, developmental delay Referred to Hem-Onc clinic for: Progressively worsening cough Neck swelling Abnormal chest x-ray

    Slide 3:History

    Over the past 3 mos Increasing cough Initially treated with Abx ? improved Exacerbated by lying supine Associated with respiratory distress Axillary lymphadenopathy ~ 2 mos prior Also treated with Abx ? improved Past few weeks b/l neck swelling Swelling of face 5-6 lbs weight loss No fevers, N/V/D, bone pain, or neuro changes

    Slide 4:Past Medical History

    No prior hospitalizations No surgical hx + seizure disorder Levetiracetam Clonazepam Lamotrigine + autism + developmental delay

    Slide 5:Physical Examination

    NAD, slightly anxious, slightly thin female, interactive, leaning forward T = 35.8, RR 22, HR 133, BP 102/69, O2 sats 98% on RA HEENT - WNL B/L supraclavicular adenopathy Large, firm, 5x8cm each, NT

    Slide 6:Physical Examination

    Some swelling noted on anterior chest wall with increased prominence of anterior chest wall veins No breath sounds on the left; clear on the right PMI shifted to the midline; no m/r/g Abdo soft, NT, ND, No HSM

    Slide 7:Labs

    15.3 9.4 30.3 695 6 B, 66 N, 12 L, 10 M ESR 94 3.7 99 27 12 .72 138 84 10.5 Phos 7.7, Mg 2.3 Alb 3.9 , TP 7.7 LDH 686, AP 91 AST 24, ALT 8, TB 0.3 Uric Acid 5.2

    Slide 10:Differential DiagnosisDifferential Diagnosis

    Slide 11:Differential Diagnosis

    Non-Hodgkin lymphoma Metastatic adenopathy from other primary tumors Toxoplasmosis Mycobacterium EBV SLE Malignant, infectious, inflammatory Thymoma, thyroid dz or cancer, teratoma, rhabdomyosarcoma, germ cell tumor or T cell lymphoblastic lymphoma Malignant, infectious, inflammatory Thymoma, thyroid dz or cancer, teratoma, rhabdomyosarcoma, germ cell tumor or T cell lymphoblastic lymphoma

    Slide 12:Pathology

    Biopsy Classical Hodgkin Lymphoma Nodular sclerosis subtype Bone marrow aspirates Active tri-lineage haematopoiesis No evidence of malignancy

    Slide 13:Objectives

    To discuss the epidemiology, presentation, & diagnostic evaluation for Hodgkin’s Lymphoma To discuss the differential diagnosis for anterior mediastinal masses To discuss the treatment for Hodgkin’s Lymphoma To discuss new development regarding prognostic indicators for Hodgkin’s Lymphoma

    Slide 14:History

    Highly curable malignant disease First cancer to be cured with radiation or with a combination of several chemotherapy agents Therapeutic success ? long-term toxicities 30-year survivor is more likely to die of therapy-related complications than from HL current risk-adapted, response-based approach to treatment

    Slide 15:Pathophysiology

    B-cell malignant disorder that affects the reticuloendothelial and lymphatic systems Can affect other organs and systems, predominantly the lungs, bone, bone marrow, liver parenchyma, and, rarely, the CNS

    Slide 16:Pathophysiology

    Epidemiologic data suggest environmental, genetic, and immunologic factors are involved Clustering of cases in families or racial groups supports the idea of a genetic predisposition or a common environmental factor In identical twins of patients with HL, the risk of developing HL is higher than that of other first-degree relatives Subjects with acquired or congenital immunodeficiency disorders also have an increased risk of developing HL

    Slide 17:Pathophysiology

    Findings from several epidemiologic studies suggest links between HL and certain viral illnesses The strongest case to date is a relationship to EBV EBV viral DNA can be found in Hodgkin-Reed-Sternberg (HRS) cells 25-50% of cases of classical HL in developed countries are EBV +

    Slide 18:Incidence

    Age-adjusted standardized rate (ASR) in North America, western Europe, and Oceania is usually just below 7 cases per million For children and adolescents younger than 15 years, the incidence is 5.5 cases per million For individuals aged 15-20 years, the incidence is 12.1 cases per million Western Asia (from the Mediterranean to northwest India), the ASR is consistently higher than 7 cases per million

    Slide 19:Incidence

    In the US, the incidence among whites and blacks is essentially the same. However, the ratio is 1.4:1 in children older than 10 years A significant male-to-female predominance of 3:1 is observed in children younger than 10 years In older children and adults, the male-to-female ratio is about 1:1

    Slide 20:Incidence

    The incidences by age show a bimodal distribution In developed nations, the first peak occurs at approximately age 20, and the second peak is observed in patients aged 55 years or older HL is uncommon before age 5 years. However, in developing countries, the first peak is shifted into childhood, usually before adolescence

    Slide 21:History

    Persistent painless adenopathy More than 70% of patients with HL present with cervical lymphadenopathy Patients with mediastinal adenopathy may present with respiratory symptoms such as shortness of breath, chest pain, or cough at risk for respiratory failure, especially if they undergo sedation or anesthesia for diagnostic procedures 17-40% of children with HL have a mediastinal mass on CXR at initial presentation; can initially c/o dysphagia, dyspnea, cough, stridor, or SVC syndrome17-40% of children with HL have a mediastinal mass on CXR at initial presentation; can initially c/o dysphagia, dyspnea, cough, stridor, or SVC syndrome

    Slide 22:History

    Patients with HL may present with symptoms associated with advanced disease & adverse prognosis (B – designation) Unexplained fever with temperatures above 38°C for 3 consecutive days Unexplained weight loss of 10% or more in the previous 6 months Drenching night sweats Fewer than 20% of children with HL have the classic fever and night sweats seen in adults. Pts can also present with pruritis, urticaria, fatigue postulated to be secondary to cytokine release from HRS cellsFewer than 20% of children with HL have the classic fever and night sweats seen in adults. Pts can also present with pruritis, urticaria, fatigue postulated to be secondary to cytokine release from HRS cells

    Slide 24:Diagnostic Evaluation

    In addition to stage and male sex, certain laboratory findings suggest poor prognostic factors Hemoglobin < 10.5 g/dL WBC count of 15,000/µL or less Absolute lymphocyte count < 800/µL Albumin level < 4 g/dL ESR > 50

    Slide 25:Imaging

    Chest XR – AP and lateral Mediastinal mass with a thoracic ratio of 33% or greater is of prognostic importance CT or MRI of neck, chest, abdomen, and/or pelvis to assess sites of disease (nodal and extranodal) as well as to assess liver and spleen involvement PET scans to identify the extent of disease at diagnosis and for follow up

    Slide 26:Staging

    The most widely used staging system is the Ann Arbor staging system. Stage I - Single lymph node region or single extranodal site Stage II - Two or more lymph node regions on the same side of the diaphragm Stage III - Lymph node regions on both sides of the diaphragm Stage IV - Diffuse or disseminated involvement of one or more extralymphatic organs (liver, bone marrow, lung) or tissues with or without associated lymph node involvement (The spleen is considered a nodal site.) A vs B

    Slide 27:Treatment

    Hodgkin lymphoma can be cured with radiation therapy, chemotherapy, or a combination of both. Acute and late toxicities vary depending on treatment Balance between reducing late effects of therapy vs. maintaining cure rates

    Slide 28:Treatment based on Stage

    Standard treatment regimens for pediatric Hodgkin lymphoma are as follows: Early or favorable disease (stage IA or IIA with <3 nodal sites) 2-4 chemotherapy cycles without alkylators (VAMP; etoposide, bleomycin, vinblastine, and prednisone [EBVP]; OEPA; or ABVE) plus low-dose, involved-field radiation of 15-30 Gy or 6 chemotherapy cycles (alternating COPP and ABVD or derivatives of these regimens) and no irradiation. The use of very limited doses of chemotherapy (2-3 cycles) should be administered only as part of a clinical trial. Intermediate-risk disease (stage IA, IIA, or IIA bulky disease with extension or >3 nodal sites): 4-6 chemotherapy cycles (OPPA and COPP, Stanford V) plus low-dose, involved-field radiation of 15-30 Gy or 6 chemotherapy cycles (alternating COPP and ABVD or their derivatives) or a dose-intense, hybrid regimen (eg, Stanford V, ABVE-PC, or BEACOPP) and no irradiation. Advanced or unfavorable disease (stages IIB, IIIB, or IV): 6-8 chemotherapy cycles (OPPA and/or COPP, ABVE-PC, BEACOPP) plus low-dose involved-field radiation of  15-30 Gy or 6-8 chemotherapy cycles (alternating COPP and ABVD or their derivatives) or a dose-intense, hybrid regimen (ABVE-PC or BEACOPP) and no irradiation.

    Slide 29:Acute Effects of Treatment

    Radiation Erythema +/- hyperpigmentation Transient hair thinning GI sx Dry mouth or altered taste Chemotherapy N/V Alopecia Myelosuppression Immunosuppression Most children and adolescents with HL have EXCELLENT prognosis with current therapy regimens. Overall 5 year survival rate for early disease >90%. The overall 5 year survival rate in patients with advanced stage disease treated with chemo + radiation ~93%Most children and adolescents with HL have EXCELLENT prognosis with current therapy regimens. Overall 5 year survival rate for early disease >90%. The overall 5 year survival rate in patients with advanced stage disease treated with chemo + radiation ~93%

    Slide 30:Late Complications

    Impaired growth of soft tissue and bones Thyroid dysfunction Gonadal dysfunction Cardiopulmonary toxicity Second malignancies Functional impairment and reduced overall general health A majority of these late complications are dose and volume related to the amount of chemo +/- radiation receivedA majority of these late complications are dose and volume related to the amount of chemo +/- radiation received

    Slide 31:Steidl et al.

    New England Journal of Medicine About 20% of HL patients cannot be cured About 20% of HL patients are over-treated "An increased number of tumor-associated macrophages was strongly associated with shortened survival in patients with classic Hodgkin's lymphoma, and provides a new biomarker for risk stratification" The tumor-associated macrophages were identified by a single marker of CD68+ cells Steidl et al. Tumor-Associated Macrophages and Survival in Classic Hodgkin’s Lymphoma. N Engl J Med. 2010; Vol 362, No 10:875-85 Using gene-expression profiling – analyzed 130 frozen samples obtained from patients with classic HL during diagnostic LN bx to determine which cellular signatures were correlated with treatment outcome. Then they confirmed these findings in an independent cohort of 166 patients using immunohistochemical analysis for CD68 markers on macrophages – which per the study can be done by all pathology departmentsUsing gene-expression profiling – analyzed 130 frozen samples obtained from patients with classic HL during diagnostic LN bx to determine which cellular signatures were correlated with treatment outcome. Then they confirmed these findings in an independent cohort of 166 patients using immunohistochemical analysis for CD68 markers on macrophages – which per the study can be done by all pathology departments

    Slide 32:Tumor-Associated Macrophages

    Previously, thought that macrophages were a manifestation of an immune response against the tumor Currently, Lewis et al (2006) link the presence of tumor-associated macrophages with a poor prognosis Possibly by increasing blood-vessel formation through the secretion of vascular endothelial growth factor Steidl et al.. N Engl J Med. 2010; Vol 362, No 10:875-85 Along with Lewis et al - Pollard et al 2009; Mantovani et al 1992 Possibly, the number of tumor associated macrophages leads to a poor response to treatment because their increased number signals a deregulation of apoptosis in Reed-Sternberg cells that inhibits cell death in response to cytotoxic agents???? Along with Lewis et al - Pollard et al 2009; Mantovani et al 1992 Possibly, the number of tumor associated macrophages leads to a poor response to treatment because their increased number signals a deregulation of apoptosis in Reed-Sternberg cells that inhibits cell death in response to cytotoxic agents????

    Slide 33:Implications of CD68 marker

    Identify the subgroup of patients with HL who have a poor prognosis and prescribe aggressive treatment with both radiotherapy and combination chemotherapy Would spare majority of the patients from over treatment and associated toxicities Steidl et al.. N Engl J Med. 2010; Vol 362, No 10:875-85 FUTURE = Catering therapy!!!FUTURE = Catering therapy!!!

    Slide 34:References

    Jemal et al. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225 Alexander et al. Risk factors for Hodgkin’s disease by EBV antibodies – a prospective study. Br J Cancer 2000; 82:1117 Steidl et al. Tumor-Associated Macrophages and Survival in Classic Hodgkin’s Lymphoma. N Engl J Med. 2010;Vol 362; No 10: 875-85 Lewis et al. Distinct role of macrophages in different tumor microenvironments. Cancer Res 2006;66:605-12 Pollard et al. Trophic macrophages in development and disease. Nat Rev Immuno 2009;9:259-70 Montovani et al. The origin and function of tumor-associated macrophages. Immunol Today 1992;13:265-70 DeVita et al. A selective history of the therapy of Hodgkin’s disese. Br J Haematol 2003;122:718-27 www.instantanatomy.net (figure)

More Related