Altamofen Tablets (Generic Tamoxifen Citrate Tablets)

1. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) © The Swiss Pharmacy

2. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Altamofen (Generic Tamoxifen Citrate Tablets) is used for the treatment of breast cancer, the treatment of anovulatory infertility and the primary prevention of breast cancer in women at moderate or high risk. This medication can block the growth of breast cancer. It works by interfering with the effects of estrogen in the breast tissue. © The Swiss Pharmacy

3. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Altamofen Tablets are manufactured by Alpha Pharma Healthcare Private limited, India in the strength of 20 mg. © The Swiss Pharmacy

4. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Chemical Structure © The Swiss Pharmacy

5. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) The active ingredient contained in Altamofen tablets is Tamoxifen Citrate. Each 20 mg tablet of Altamofen contains 30.4 mg of Tamoxifen Citrate which is equivalent to 20 mg of Tamoxifen. © The Swiss Pharmacy

6. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Uses of Altamofen 20 mg Tablets: Tamoxifen Tablets are used to treat breast cancer. Tamoxifen citrate tablets are effective in the treatment of estrogen receptor-positive metastatic breast cancer in women and men. Tamoxifen Citrate tablets are indicated for the treatment of node- positive breast cancer in postmenopausal women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation. In women with DCIS, following breast surgery and radiation, Tamoxifen Citrate tablets are indicated to reduce the risk of invasive breast cancer . For adjuvant treatment of adult patients with early stage estrogen receptor-positive breast cancer URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

7. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Uses of Altamofen 20 mg Tablets: Altamofen (Generic Tamoxifen Citrate Tablets) are also used to treat infertility in women caused by a failure to produce and release eggs (ovulate) properly. Tamoxifen Citrate Tablets can also reduce the risk of developing breast cancer occurring in those women who have an increased likelihood of developing breast cancer (your risk). It is important that your healthcare professional calculates your risk of developing breast cancer and discusses the result with you before commencing treatment. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

8. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) How Does Altamofen 20 mg Tablets Work? Tamoxifen blocks the effects of estrogen — a reproductive hormone that influences the growth and development of many breast cancers. Tamoxifen belongs to a class of drugs known as selective estrogen receptor modulators (SERMs). The drug reduces the effects of estrogen in most areas of the body, including the breast. In the uterus, however, Tamoxifen acts like an estrogen and encourages the growth of the lining of the uterus. Tamoxifen is usually prescribed as a pill taken once a day by mouth. For breast cancer risk reduction, tamoxifen is typically taken for a total of five years. The risk reduction benefit continues for five additional years after you stop taking Tamoxifen. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

9. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Recommended Adult Dosage Breast Cancer: For patients with breast cancer, the recommended daily dose of Altamofen Tablets Altamofen Tablets (Generic Tamoxifen Tablets) is 20 mg to 40 mg. Dosages greater than 20 mg per day should be given in divided doses (morning and evening). Ductal Carcinoma in Situ (DCIS): The recommended dose is 20 mg of Altamofen daily for 5 years. Reduction in Breast Cancer Incidence in High Risk Women: The recommended dose is 20 mg of Altamofen daily for 5 years. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

10. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Recommended Adult Dosage Infertility (Anovulatory Disorders): The possibility of pregnancy must be excluded before the commencement of treatment, whether initial or subsequent. The recommended dosage of Altamofen Tablets (Tamoxifen Citrate) iIn women with regular menstruation but with anovular cycles, treatment should commence with 20 mg daily in either one or two doses administered on the second, third, fourth and fifth days of the menstrual cycle. In unsuccessful cases further courses may be given during subsequent menstrual periods, increasing the dosage to 20 mg then 40 mg twice daily. In women with irregular menstruation, the commencement of treatment may take place on any day. If this initial course is not successful then a further course may be initiated after an interval of 45 days with the higher dosage level (20 mg to 40 mg twice daily). © The Swiss Pharmacy

11. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Contraindications ➔Altamofen is contraindicated in patients with a known hypersensitivity to Tamoxifen Citrate or any component of the tablet. ➔Pre-menopausal patients must be carefully examined before treatment for all indications to exclude the possibility of pregnancy. ➔Concurrent Anastrozole therapy is contraindicated. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

12. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Contraindications ➔For the treatment for infertility, Tamoxifen should not be used in patients with a personal or family history of confirmed idiopathic venous thromboembolic events or a known genetic defect. ➔For the indication of primary prevention of breast cancer, Tamoxifen should not be used in Women with a history of deep vein thrombosis or pulmonary embolus and women who require concomitant coumarin-type anticoagulant therapy. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

13. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Storage Instructions Altamofen (Generic Tamoxifen Citrate Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

14. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Warnings There is evidence of an increased incidence of thromboembolic events, including deep vein thrombosis and pulmonary embolism, during tamoxifen therapy. Risk of thromboembolic effects increases with coadministered chemotherapy. For treatment of breast cancer, consider risks and benefits in patients with a history of thromboembolic events. In the Swedish trial using adjuvant Tamoxifen 40 mg/day for 2-5 years, 3 cases of liver cancer have been reported in the tamoxifen-treated group vs. 1 case in the observation group. In other clinical trials evaluating tamoxifen, no cases of liver cancer have been reported to date. One case of liver cancer was reported in NSABP P-1 in a participant randomized to Tamoxifen. © The Swiss Pharmacy

15. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Warnings Tamoxifen has been associated with changes in liver enzyme levels, and on rare occasions, a spectrum of more severe liver abnormalities including fatty liver, cholestasis, hepatitis and hepatic necrosis. A number of second primary tumors, occurring at sites other than the endometrium, have been reported following the treatment of breast cancer with Tamoxifen in clinical trials. Can cause fetal harm. Advise females of reproductive potential of the potential risk to a fetus and to use effective contraception. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

16. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Warnings Ocular disturbances, including corneal changes, decrement in color vision perception, retinal vein thrombosis, and retinopathy have been reported in patients receiving Tamoxifen. An increased incidence of cataracts and the need for cataract surgery have been reported in patients receiving Tamoxifen. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

17. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Possible Side Effects In patients treated with Tamoxifen Citrate Tablets (Altamofen) for metastatic breast cancer, the most frequent side effect to Tamoxifen is hot flashes. Other side effects which are seen infrequently are hypercalcemia, peripheral edema, distaste for food, pruritus vulvae, depression, dizziness, light-headedness, headache, hair thinning and/or partial hair loss, and vaginal dryness. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

18. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Overdosage Acute overdosage of Tamoxifen Citrate Tablets (Altamofen) in humans has not been reported. In a study of advanced metastatic cancer patients which specifically determined the maximum tolerated dose of Tamoxifen tablets in evaluating the use of very high doses to reverse multidrug resistance, acute neurotoxicity manifested by tremor, hyperreflexia, unsteady gait and dizziness were noted. These symptoms occurred within 3 to 5 days of beginning Tamoxifen and cleared within 2 to 5 days after stopping therapy. No permanent neurologic toxicity was noted. No specific treatment for Tamoxifen Citrate overdosage is known and treatment must be symptomatic. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

19. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Altamofen Tablets During Pregnancy Tamoxifen Citrate (Altamofen Tablets) has been classified by the US FDA as Pregnancy Category D. Tamoxifen Tablets (Altamofen) may cause fetal harm when administered to a pregnant woman. Women should be advised not to become pregnant while taking Altamofen or within 2 months of discontinuing Altamofen and should use barrier or nonhormonal contraceptive measures if sexually active. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

20. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Altamofen Tablets During Pregnancy There have been a small number of reports of vaginal bleeding, spontaneous abortions, birth defects, and fetal deaths in pregnant women. If this medicine is used during pregnancy, or the patient becomes pregnant while taking this medication, or within approximately two months after discontinuing therapy, the patient should be apprised of the potential risks to the fetus including the potential long-term risk of a DES-like syndrome. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy

21. Altamofen Tablets (Generic Tamoxifen Citrate Tablets) Altamofen Tablets Altamofen Tablets (Generic Tamoxifen Citrate Tablets) are manufactured by Alpha Pharma Healthcare Private limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9948_Altamofen-Tablets.html © The Swiss Pharmacy