Stamlo Tablets (Generic Amlodipine Besylate Tablets)

1. Stamlo Tablets (Generic Amlodipine Besylate Tablets) © The Swiss Pharmacy

2. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Stamlo (Generic Amlodipine Besylate Tablets) is used alone or together with other medicines to treat hypertension (lower high blood pressure) in adults and children. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Amlodipine tablets are also used to prevent certain types of chest pain (angina). © The Swiss Pharmacy

3. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Stamlo Tablets are manufactured by Dr. Reddy's Laboratories Limited, India in the strengths of 2.5 mg, 5 mg and 10 mg. © The Swiss Pharmacy

4. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Chemical Structure © The Swiss Pharmacy

5. Stamlo Tablets (Generic Amlodipine Besylate Tablets) The active ingredient contained in Stamlo tablets is Amlodipine Besylate (Amlodipine Besilate). Each uncoated Stamlo tablet contains Amlodipine Besylate equivalent to Amlodipine 2.5 mg, 5 mg or 10 mg. © The Swiss Pharmacy

6. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Uses of Stamlo 2.5 mg, 5 mg or 10 mg Tablets: Stamlo (Generic Amlodipine Besylate Tablets) is used alone or together with other medicines to treat hypertension (high blood pressure). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Amlodipine is also used to relieve chronic stable angina (chest pain) or vasospastic angina (Prinzmetal's or variant angina). This medicine is also used to lower the risk of hospitalization for angina and heart surgery (eg, coronary revascularization) in patients with recently documented coronary artery disease (CAD) by angiography and without certain heart problems (eg, heart failure or an ejection fraction less than 40%). © The Swiss Pharmacy

7. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Uses of Stamlo 2.5 mg, 5 mg or 10 mg Tablets: Amlodipine Besylate (Stamlo Tablets) is a calcium channel blocker. It affects the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels and lowers blood pressure. A lower blood pressure will increase the supply of blood and oxygen to the heart. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy

8. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Recommended Adult Dosage For most adult patients, the starting dose of Stamlo tablets (Amlodipine Besylate tablets) for the treatment of Hypertension Hypertension is 5 mg once daily, with a maximum dose of 10 mg once daily. Small, fragile or elderly individuals or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding Stamlo (Amlodipine Besilate) to other anti-hypertensive therapy. The starting dose for pediatric patients is 2.5 mg to 5 mg once daily. Stamlo tablets treatment of URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy

9. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Recommended Adult Dosage Chronic Stable or Vasospastic Angina: Chronic Stable or Vasospastic Angina: The starting dose of Stamlo (Amlodipine Besilate) is 5 mg to 10 mg with a lower dose (2.5 mg) in the elderly and in patients with hepatic insufficiency. The recommended dose range for patients with Coronary Artery Disease (CAD) is 5mg to 10 mg once daily. During clinical studies, the majority of patients required 10 mg. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy

10. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Contraindications ➔Stamlo is contraindicated in patients with a known hypersensitivity to Amlodipine Besylate, other dihydropyridines or any component of the tablet. ➔Amlodipine is transferred into human breast milk, therefore Stamlo is contraindicated during breast-feeding. ➔Stamlo, is also contraindicated in patients with severe hypotension, shock including cardiogenic shock, obstruction of the outflow tract of the left ventricle (e.g. high grade aortic stenosis) and haemodynamically unstable heart failure after acute myocardial infarction. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy

11. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Storage Instructions Stamlo Tablets (Generic Amlodipine Besylate Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy

12. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Warnings Symptomatic hypotension is possible, particularly in patients with severe aortic stenosis. However, because of the gradual onset of action, acute hypotension is unlikely. Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of Stamlo, particularly in patients with severe obstructive coronary artery disease. Titrate slowly when administering calcium channel blockers to patients with severe hepatic impairment. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy

13. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Possible Side Effects Most common Amlodipine Besylate (Stamlo tablets) side effects are headache and edema which occurred in a dose related manner. Other side effects not dose related but reported with an incidence more than 1.0% are headache, fatigue, nausea, abdominal pain, and somnolence. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy

14. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Possible Side Effects The following events occurred in less than 1% but more than 0.1% of patients in controlled clinical trials or under conditions of open trials or marketing experience: Cardiovascular: arrhythmia (including ventricular tachycardia and atrial fibrillation), bradycardia, chest pain, peripheral ischemia, syncope, tachycardia, vasculitis. Central and Peripheral Nervous System: hypoesthesia, neuropathy peripheral, paresthesia, tremor, vertigo. Gastrointestinal: anorexia, constipation, dysphagia, diarrhea, flatulence, pancreatitis, vomiting, gingival hyperplasia. General: allergic reaction, asthenia,back pain, hot flushes, malaise, pain, rigors, weight gain, weight decrease. Musculoskeletal System: arthralgia, arthrosis, muscle cramps, myalgia. © The Swiss Pharmacy

15. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Possible Side Effects Psychiatric: sexual dysfunction (male and female), insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization. Respiratory System: dyspnea, epistaxis. Skin and Appendages: angioedema, erythema multiforme, pruritus, rash, rash erythematous, rash maculopapular. Special Senses: abnormal vision, conjunctivitis, diplopia, eye pain, tinnitus. Urinary System: micturition frequency, micturition disorder, nocturia. Autonomic Nervous System: dry mouth, sweating increased. Metabolic and Nutritional: hyperglycemia, thirst. Hemopoietic: leukopenia, purpura, thrombocytopenia. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy

16. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Overdosage Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. In humans, experience with intentional overdosage of Amlodipine Besylate (Stamlo tablets) is limited. Single oral doses of Amlodipine Maleate equivalent to 40 mg Amlodipine/kg and 100 mg Amlodipine/kg in mice and rats, respectively, caused deaths. Single oral Amlodipine Maleate doses equivalent to 4 or more mg Amlodipine/kg or higher in dogs (11 or more times the maximum recommended human dose on a mg/m2 basis) caused a marked peripheral vasodilation and hypotension. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy

17. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Overdosage If massive overdose should occur, initiate active cardiac and respiratory monitoring. Frequent blood pressure measurements are essential. Should hypotension occur, provide cardiovascular support including elevation of the extremities and the judicious administration of fluids. If hypotension remains unresponsive to these conservative measures, consider administration of vasopressors (such as phenylephrine) with attention to circulating volume and urine output. As Amlodipine Besylate (Stamlo tablets) is highly protein bound, hemodialysis is not likely to be of benefit. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy

18. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Stamlo Tablets During Pregnancy Amlodipine Besylate (Stamlo tablets) has been classified by the US FDA as Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. No evidence of teratogenicity or other embryo/fetal toxicity was found when pregnant rats and rabbits were treated orally with amlodipine maleate at doses up to 10 mg Amlodipine/kg/day (respectively, 8 times and 23 times the maximum recommended human dose of 10 mg on a mg/m2 basis) during their respective periods of major organogenesis. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy

19. Stamlo Tablets (Generic Amlodipine Besylate Tablets) Stamlo Tablets Stamlo Tablets (Generic Amlodipine Besylate Tablets) are manufactured by Dr. Reddy's Laboratories Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9583_Stamlo-Tablets.html © The Swiss Pharmacy