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Levamlodipine Besylate New CCB half dose, save efficiency and safety

Levamlodipine Besylate New CCB half dose, save efficiency and safety. Dayi Hu, MD, FACC, FHRS , FESC Medical school of Tongji University, Shanghai People’s Hospital of Peking University,Beijing. Amlodipine

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Levamlodipine Besylate New CCB half dose, save efficiency and safety

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  1. Levamlodipine BesylateNew CCB half dose, save efficiency and safety Dayi Hu, MD, FACC, FHRS, FESC Medical school of Tongji University, Shanghai People’s Hospital of Peking University,Beijing

  2. Amlodipine A typical modern long acting Ca2+ channel blocker with significant antihypertensive effect.

  3. The antihypertensive effect in different age groups

  4. Significant antihypertensive effect *P<0.001

  5. Outstanding antihypertensive effect Amlodipine vs. Lasartan n=93 n=97 P<0.001

  6. Significant antihypertensive effect Amlodipine vs. ACEI , ARB (The Aged Hypertension) Amlodipine vs. ACEI, P=0.008 Amlodipine vs. ARB, P=NS

  7. VALUE Study: Valsartan / Amlodipine The major heart terminals Incidence of heart disease Death of heart diseases All myocardial infarction All congestive heart failure All cerebral apoplexy Death caused by all the reasons New onset diabetes 0.5 1 2 Julius S et al. Lancet. June 2004;363.

  8. P=0.032 P=0.002 P=0.004 P=0.038 Amlodipine is remarkably superior in reducing the rate of cerebral apoplexy compared to other antihypertensive drugs Franz H. Messerli et al. Hypertension. 2006;48:359-361. VS.Placebo VS.ACEI VS.ARB VS. Diuretic /β-Blocker ALLHAT(n=24309)/ASCOT (n=19257) 14% 16% 18% Decrease of the risk of occurrence of cerebral apoplexy(%) IDNT(n=1146)/VALUE(n=15245) ALLHAT(n=18102)/CAMELOT(n=1336) 40% PREVENT(n=825)/CAMELOT(n=1318)/IDNT(n=1136)

  9. Amlodipine can effectively control early morning BP increase Its consistent 24 hour antihypertension effect It’s superior than other CCB in decreasing the rate of early morning BP increase. The speed of early morning BP increase before and after treatment Before treatment After treatment * P<0.05 SBP DBP mmHg/H * * Felodipine 10mg QD N=15 Nifedipine 60mg QD N=20 Nifedipine 60mg QD N=20 Amlodipine 10mg QD N=20 Amlodipine 10mg QDN=20 Felodipine 10mg QD N=15 C. Macchiarulo et al. Cur Ther Res Clin Exp. 2001;62:236-253.

  10. Levamlodipine (Shi Hui Da) • Amlodipine is a racemic compound composed of levorotary and dextrorotary forms. The Ca2+ antagonist activity of levorotary form is approxim-ately 1,000 times of the one of dextrorotary form and twice of the one of racemic compound.. • Levamlodipine: half dose --the same effect of racemic amlodipine. Less side effects. —— The New Generation Products of Amlodipine

  11. Levamlodipine besylate(Shi Hui Da) Similar effectiveness in antihypertension? Safer? Equal organ protection effect? Amlodipine besylate(Norvasc) V.S.

  12. One of the Clinical Studies: Levamlodipine vs Amlodipine Chinese Journal of Medicine, 2002,37(5);46-47

  13. Multi-center clinical study The People’s Hospital of Beijing University (Hu Dayi, PI) Capital Medical University Affiliated Beijing Tongren Hospital Capital Medical University Affiliated Beijing Youyi Hospital Capital Medical University Affiliated Beijing Xuanwu Hospital Sino-Japan Friendship Hospital Armed Police Contingent Hospital of Beijing The No. 3 Hospital of Beijing University Beijing Hospital Capital Medical University Affiliated Beijing Fuxing Hospital Beijing Willow Hospital

  14. The trough / peak value of levamlodipine besylate (Shi Hui Da)

  15. The changes of BP before treatment, after treatment and during drug holidays CBP, n=80 *p<0.05: The value of SBP and DBP at the end of 8 weeks’ treatment compared with those of no drug administered. #p>0.05: The value of SBP and DBP after not administered for 24h or 48h compared with those at the end of 8 weeks’ treatment.

  16. The reduction of SBP and DBP after eight weeks treatment in the two groups

  17. The SBP and DBP Changesduring drug holiday 1 after eight weeks treatment

  18. The SBP and DBP Changes during drug holiday 2 after eight weeks treatment

  19. Adverse Events (eight weeks treatment )

  20. Conclusion • Both 2.5mg Levamlodipine besylate and 5mg Amlodipine besylate reduce BP effectively. • The incidence of Levamlodipine adverse effects is low.

  21. Conclusion • CCB is the most common antihypertensive drug used in Chinese hypertensives. • Levamlodipine besylate (Shi Hui Da) is both save and effective. • Half dosage, Same effect and safety.

  22. Thanks！

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