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Where does the JRC fitin the European Commission?. The Joint Research Centre. Centre of scientific and technical referencefor the conception, development and monitoring of EU policies. 7 Institutes in 5 Member States ? 2800 staff. IE - Petten The NetherlandsInstitute for Energy IRMM - Geel Belgium- Institute for Reference Materials and Measurements ITU - Karlsruhe Germany - Institute for Transuranium ElementsIPSC - IHCP - IES - Ispra Italy- Institute for Environment and Sust9442
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1. NOTES
1. PLACE, DATE AND EVENT NAME
1.1. Access the slide-set place, date and event name text box beneath the JRC logo from the Slide Master.
1.2. Do not change the size nor the position of that text box.
1.3. Replace the mock-up texts for the place (“Place”), the date (“dd Month YYYY”) and the event name (“Event Name”) with your own texts.
1.4. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
1.5. Keep the original flush-left justification.
1.6. Keep the original font colour (white).
1.7. Keep the original font body size (7 pt) and the text on one single line.
2. SLIDE NUMBER
2.1. The slide number on the banner’s lower right-hand side is automatically generated.
3. SLIDES
3.1. Duplicate the first slide as needed.
3.2. Do not change the size nor the position of the slide’s text box.
3.3. Try not to place more text on each slide than will fit in the given text box.
3.4. Replace the mock-up heading text (“Joint Research Centre (JRC)”) with your own text heading.
3.5. Set it in Eurostile Bold Extended Two or in Helvetica Rounded Bold Condensed, if you own one of these typefaces. Otherwise, keep the original typeface – Arial.
3.6. Keep the original flush-left justification.
3.7. Keep the original font colour (100c 80m 0y 0k).
3.8. Keep the original font body size (28 pt) and the heading on one single line whenever possible. Reduce the font body size if needed.
3.9. Replace the mock-up text (“The European Commission’s Research-Based Policy Support Organisation)”) with your own text.
3.10. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
3.11. Keep the original flush-left justification.
3.12. Keep the original font colour (100c 80m 0y 0k). Use black if you need a second colour.
3.13. Keep the original font body size (22 pt) or reduce it if unavoidable.
3.14. Replace the EU-27 map mock-up illustration with your own illustration(s).
3.13. Try to keep your illustration(s) right- and top- or bottom-aligned with the main text box whenever possible.
NOTES
1. PLACE, DATE AND EVENT NAME
1.1. Access the slide-set place, date and event name text box beneath the JRC logo from the Slide Master.
1.2. Do not change the size nor the position of that text box.
1.3. Replace the mock-up texts for the place (“Place”), the date (“dd Month YYYY”) and the event name (“Event Name”) with your own texts.
1.4. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
1.5. Keep the original flush-left justification.
1.6. Keep the original font colour (white).
1.7. Keep the original font body size (7 pt) and the text on one single line.
2. SLIDE NUMBER
2.1. The slide number on the banner’s lower right-hand side is automatically generated.
3. SLIDES
3.1. Duplicate the first slide as needed.
3.2. Do not change the size nor the position of the slide’s text box.
3.3. Try not to place more text on each slide than will fit in the given text box.
3.4. Replace the mock-up heading text (“Joint Research Centre (JRC)”) with your own text heading.
3.5. Set it in Eurostile Bold Extended Two or in Helvetica Rounded Bold Condensed, if you own one of these typefaces. Otherwise, keep the original typeface – Arial.
3.6. Keep the original flush-left justification.
3.7. Keep the original font colour (100c 80m 0y 0k).
3.8. Keep the original font body size (28 pt) and the heading on one single line whenever possible. Reduce the font body size if needed.
3.9. Replace the mock-up text (“The European Commission’s Research-Based Policy Support Organisation)”) with your own text.
3.10. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
3.11. Keep the original flush-left justification.
3.12. Keep the original font colour (100c 80m 0y 0k). Use black if you need a second colour.
3.13. Keep the original font body size (22 pt) or reduce it if unavoidable.
3.14. Replace the EU-27 map mock-up illustration with your own illustration(s).
3.13. Try to keep your illustration(s) right- and top- or bottom-aligned with the main text box whenever possible.
2. NOTES
1. PLACE, DATE AND EVENT NAME
1.1. Access the slide-set place, date and event name text box beneath the JRC logo from the Slide Master.
1.2. Do not change the size nor the position of that text box.
1.3. Replace the mock-up texts for the place (“Place”), the date (“dd Month YYYY”) and the event name (“Event Name”) with your own texts.
1.4. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
1.5. Keep the original flush-left justification.
1.6. Keep the original font colour (white).
1.7. Keep the original font body size (7 pt) and the text on one single line.
2. SLIDE NUMBER
2.1. The slide number on the banner’s lower right-hand side is automatically generated.
3. SLIDES
3.1. Duplicate the first slide as needed.
3.2. Do not change the size nor the position of the slide’s text box.
3.3. Try not to place more text on each slide than will fit in the given text box.
3.4. Replace the mock-up heading text (“Joint Research Centre (JRC)”) with your own text heading.
3.5. Set it in Eurostile Bold Extended Two or in Helvetica Rounded Bold Condensed, if you own one of these typefaces. Otherwise, keep the original typeface – Arial.
3.6. Keep the original flush-left justification.
3.7. Keep the original font colour (100c 80m 0y 0k).
3.8. Keep the original font body size (28 pt) and the heading on one single line whenever possible. Reduce the font body size if needed.
3.9. Replace the mock-up text (“The European Commission’s Research-Based Policy Support Organisation)”) with your own text.
3.10. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
3.11. Keep the original flush-left justification.
3.12. Keep the original font colour (100c 80m 0y 0k). Use black if you need a second colour.
3.13. Keep the original font body size (22 pt) or reduce it if unavoidable.
3.14. Replace the EU-27 map mock-up illustration with your own illustration(s).
3.13. Try to keep your illustration(s) right- and top- or bottom-aligned with the main text box whenever possible.
NOTES
1. PLACE, DATE AND EVENT NAME
1.1. Access the slide-set place, date and event name text box beneath the JRC logo from the Slide Master.
1.2. Do not change the size nor the position of that text box.
1.3. Replace the mock-up texts for the place (“Place”), the date (“dd Month YYYY”) and the event name (“Event Name”) with your own texts.
1.4. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
1.5. Keep the original flush-left justification.
1.6. Keep the original font colour (white).
1.7. Keep the original font body size (7 pt) and the text on one single line.
2. SLIDE NUMBER
2.1. The slide number on the banner’s lower right-hand side is automatically generated.
3. SLIDES
3.1. Duplicate the first slide as needed.
3.2. Do not change the size nor the position of the slide’s text box.
3.3. Try not to place more text on each slide than will fit in the given text box.
3.4. Replace the mock-up heading text (“Joint Research Centre (JRC)”) with your own text heading.
3.5. Set it in Eurostile Bold Extended Two or in Helvetica Rounded Bold Condensed, if you own one of these typefaces. Otherwise, keep the original typeface – Arial.
3.6. Keep the original flush-left justification.
3.7. Keep the original font colour (100c 80m 0y 0k).
3.8. Keep the original font body size (28 pt) and the heading on one single line whenever possible. Reduce the font body size if needed.
3.9. Replace the mock-up text (“The European Commission’s Research-Based Policy Support Organisation)”) with your own text.
3.10. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
3.11. Keep the original flush-left justification.
3.12. Keep the original font colour (100c 80m 0y 0k). Use black if you need a second colour.
3.13. Keep the original font body size (22 pt) or reduce it if unavoidable.
3.14. Replace the EU-27 map mock-up illustration with your own illustration(s).
3.13. Try to keep your illustration(s) right- and top- or bottom-aligned with the main text box whenever possible.
3. The Joint Research Centre
4. NOTES
1. PLACE, DATE AND EVENT NAME
1.1. Access the slide-set place, date and event name text box beneath the JRC logo from the Slide Master.
1.2. Do not change the size nor the position of that text box.
1.3. Replace the mock-up texts for the place (“Place”), the date (“dd Month YYYY”) and the event name (“Event Name”) with your own texts.
1.4. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
1.5. Keep the original flush-left justification.
1.6. Keep the original font colour (white).
1.7. Keep the original font body size (7 pt) and the text on one single line.
2. SLIDE NUMBER
2.1. The slide number on the banner’s lower right-hand side is automatically generated.
3. SLIDES
3.1. Duplicate the first slide as needed.
3.2. Do not change the size nor the position of the slide’s text box.
3.3. Try not to place more text on each slide than will fit in the given text box.
3.4. Replace the mock-up heading text (“Joint Research Centre (JRC)”) with your own text heading.
3.5. Set it in Eurostile Bold Extended Two or in Helvetica Rounded Bold Condensed, if you own one of these typefaces. Otherwise, keep the original typeface – Arial.
3.6. Keep the original flush-left justification.
3.7. Keep the original font colour (100c 80m 0y 0k).
3.8. Keep the original font body size (28 pt) and the heading on one single line whenever possible. Reduce the font body size if needed.
3.9. Replace the mock-up text (“The European Commission’s Research-Based Policy Support Organisation)”) with your own text.
3.10. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
3.11. Keep the original flush-left justification.
3.12. Keep the original font colour (100c 80m 0y 0k). Use black if you need a second colour.
3.13. Keep the original font body size (22 pt) or reduce it if unavoidable.
3.14. Replace the EU-27 map mock-up illustration with your own illustration(s).
3.13. Try to keep your illustration(s) right- and top- or bottom-aligned with the main text box whenever possible.
NOTES
1. PLACE, DATE AND EVENT NAME
1.1. Access the slide-set place, date and event name text box beneath the JRC logo from the Slide Master.
1.2. Do not change the size nor the position of that text box.
1.3. Replace the mock-up texts for the place (“Place”), the date (“dd Month YYYY”) and the event name (“Event Name”) with your own texts.
1.4. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
1.5. Keep the original flush-left justification.
1.6. Keep the original font colour (white).
1.7. Keep the original font body size (7 pt) and the text on one single line.
2. SLIDE NUMBER
2.1. The slide number on the banner’s lower right-hand side is automatically generated.
3. SLIDES
3.1. Duplicate the first slide as needed.
3.2. Do not change the size nor the position of the slide’s text box.
3.3. Try not to place more text on each slide than will fit in the given text box.
3.4. Replace the mock-up heading text (“Joint Research Centre (JRC)”) with your own text heading.
3.5. Set it in Eurostile Bold Extended Two or in Helvetica Rounded Bold Condensed, if you own one of these typefaces. Otherwise, keep the original typeface – Arial.
3.6. Keep the original flush-left justification.
3.7. Keep the original font colour (100c 80m 0y 0k).
3.8. Keep the original font body size (28 pt) and the heading on one single line whenever possible. Reduce the font body size if needed.
3.9. Replace the mock-up text (“The European Commission’s Research-Based Policy Support Organisation)”) with your own text.
3.10. Set it in MetaPlus Book Roman, if you own the typeface. Otherwise, keep the original typeface – Arial.
3.11. Keep the original flush-left justification.
3.12. Keep the original font colour (100c 80m 0y 0k). Use black if you need a second colour.
3.13. Keep the original font body size (22 pt) or reduce it if unavoidable.
3.14. Replace the EU-27 map mock-up illustration with your own illustration(s).
3.13. Try to keep your illustration(s) right- and top- or bottom-aligned with the main text box whenever possible.
5. Mission of JRC Institute for Reference Materials and Measurements The mission of the IRMM is to promote a common
and reliable European measurement system
in support of EU policies
IRMM - CONFIDENCE IN MEASUREMENTS®
6. Mutual recognition of measurement data to avoid unnecessary duplication of efforts
to foster confidence in certificates of analysis
to promote international trade
driven by ISO/IEC 17025 and accreditation bodies
ISO/IEC 17025 requires uncertainty and traceability statements
7. Pillars of analytical quality control
8. Standard development
9. Standard A document established
by consensus, and
approved by a recognized body, that provides, for common and repeated use,
guidelines or characteristics for activities or their results, aimed at the
achievement of the optimum degree of order in a given context.
ISO/IEC Guide 2 (1996)
10. Standards as knowledge resource Easily available
Complete documentation
Proven performance
Acceptance
Consensus
Market driven
11. Method performance criteria applicability (matrix and concentration range)
calibration, linearity, working range, sensitivity
limit of detection
limit of quantification
precision (repeatability, reproducibility)
trueness (recovery)
selectivity / specificity
ruggedness
(measurement uncertainty)
12. EURACHEM Guide: The Fitness for Purpose of Analytical Methods: A Laboratory Guide to Method Validation and Related Topics
It is often assumed that standard methods can be used straight off the shelf and the published performance data achieved straight away by whoever uses the method. This is not a safe assumption.
Competence might be established in terms of the analyst’s ability to achieve the levels of performance stated in the method, such as repeatability, limit of detection, etc. Performance verification of standardised methods (I)
13. Performance verification of standardised methods (II) IUPAC Harmonized Guidelines for Single Laboratory
Validation of Methods of Analysis
A laboratory using a collaboratively studied method, which has been found to be fit for the intended purpose, needs only to demonstrate that it can achieve the performance characteristics stated in the method
The laboratory should undertake precision studies, bias studies (including matrix variation studies), and possibly linearity studies
14. ALAAC Guide
15. Exercise Design an experimental plan to demonstrate that your laboratory has the competence to implement a standardised method for the analysis of aflatoxin B1 in peanut butter and achieve equivalent performance characteristics as given in AOAC 999.07
16. Considerations Selection of suitable test materials
Selection of suitable reference standards
Deviations from collaborative study testing conditions with respect to sampling, sample pre-treatment, and matrix effects
Number of experiments to be carried out (e.g. calibration, precision and bias study)
Statistical data treatment
Regulatory aspects
17. Work flow
18. Work flow (cont’d)
19. Sources of suitable reference materials Certified Reference Materials
NIST http://ts.nist.gov/measurementservices/referencematerials/index.cfm
IRMM http://irmm.jrc.ec.europa.eu/html/reference_materials_catalogue/catalogue/index.htm
COMAR http://www.comar.bam.de/
Quality Control Materials
FAPAS http://www.fapas.com/tmsales.cfm
20. Boundary conditions Actual testing conditions do not differ to a large extent from those during the collaborative study:
Sample pre-treatment
Instrumentation
Immunoaffinity columns
Peanut butter considered a uniform product
Blank materials for recovery (spiking) experiments and certified calibration materials available
Well characterised quality control materials available (low level and high level contamination)
21. Study design
22. Selectivity/Specificity
23. Aflatoxin B1 in peanut butter by HPLC Calibration
5 levels
2 dilutions per level
2 injections/dilution
24. Calibration function MS Excel functions
25. Weighted regression Weights=1/s2
26. Comparison of calibration models Unweighted regression
Weighted regression
27. Spiking (recovery) experiments
28. Naturally contaminated material
29. Verification of precision
30. Demonstrating control of bias
31. Conclusions Verification gives objective proof that laboratory has competence to carry out standardised procedure in compliance with specified performance criteria
Intended purpose of the method governs performance criteria to be verified
Verification results can be used to estimate measurement uncertainty
32. www.jrc.cec.eu.int
www.jrc.irmm.be
franz.ulberth@ec.europa.eu
Useful links and contacts
