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Chapter 1 Immunity system

Chapter 1 Immunity system. 陳連城博士 ( 成大基礎醫學博士 ) 行政院衛生署藥物食品檢驗局 2009.2.27. Innate immunity - A set of disease-resistance mechanisms that are not specific to a particular pathogen. - Respond immediately. It is the 1 st line of defense during the critical period just after

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Chapter 1 Immunity system

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  1. Chapter 1 Immunity system 陳連城博士 (成大基礎醫學博士) 行政院衛生署藥物食品檢驗局 2009.2.27

  2. Innate immunity - A set of disease-resistance mechanisms that are not specific to a particular pathogen. - Respond immediately. It is the 1st line of defense during the critical period just after the host’s exposure to a pathogen. -macrophages

  3. Adaptive immunity • - Displays a high degree of specificity. • Occurs within 5 or 6 days after the initial • exposure to an Ag. • Exposure to the same Ag some time in the • future results in a memory response: • respond more quickly, stronger, and often • more effective in neutralizing and clearing • the pathogen. • - lymphocytes & Ab

  4. Hematopoietic stem cell (HSC) Pluripotent (self renewal): cytokines 1. T progenitor 2. B progenitor cytokines 1. T cell 2. B cell Lymphoid stem cell 1. Monocyte, macrophage, neutrophil 2. Eosinophil 3. Basophil 4. Erythrocyte 5. platelets 1. Granulocyte/monocyte progenitor 2. Eosinophil progenitor 3. Basophil progenitor 4. Erythroid progenitor 5. megakaryocyte cytokines cytokines Myeloid stem cell

  5. Figure 1-3

  6. Figure 1-7

  7. Figure 1-8 part 1 of 2

  8. Figure 1-9

  9. Figure 1-9 part 2 of 3

  10. Figure 1-10 part 1 of 2

  11. Figure 1-24

  12. Figure 1-32

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