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Sudden Cardiac Death in Heart Failure Trial

SCD-HeFT. Sudden Cardiac Death in Heart Failure Trial. Presented at American College of Cardiology Scientific Sessions 2004 Presented by Dr. Gust H. Bardy. SCD-HeFT. 2,521 patients with moderately symptomatic CHF (NYHA Class II or III) and LVEF ≤35% Randomized, double-blind, multicenter.

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Sudden Cardiac Death in Heart Failure Trial

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  1. SCD-HeFT Sudden Cardiac Death in Heart Failure Trial Presented at American College of Cardiology Scientific Sessions 2004 Presented by Dr. Gust H. Bardy

  2. SCD-HeFT 2,521 patients with moderately symptomatic CHF (NYHA Class II or III) and LVEF ≤35% Randomized, double-blind, multicenter Conventional CHF Treatment + Placebo Conventional CHF Treatment + ICD Single lead implantable cardioverter defibrillator programmed for ventricular fibrillation (VF) treatment only • Conventional CHF Treatment + Amiodarone • Antiarrhythmic agent • 800 mg Week 1, 400 mg Week 2-4 • Chronic therapy: • 200 mg/day if <150 lbs • 300 mg/day if 150-200 lbs • 400 mg/day if >200 lbs Treatment • Endpoints (median 45.5 months): All-cause mortality Presented at ACC Scientific Sessions 2004

  3. SCD-HeFT All-cause mortality at 5 years Amiodarone vs placebo HR 1.06, p=0.529 ICD vs placebo HR 0.77, p=0.007 • Medication use at end of follow-up included 72% ACE-inhibitors, 78% beta-blockers, 80% loop diuretics, and 55% ASA • Prior duration of CHF was 24.5 months at baseline • No difference in all-cause mortality between amiodarone and placebo arm • Mortality was lower in ICD arm vs placebo % Mortality Presented at ACC Scientific Sessions 2004

  4. SCD-HeFT • Among patients with NYHA Class II or Class III CHF and reduced left ventricular ejection fraction, treatment with an implantable ICD was associated with a reduction in all-cause mortality compared with placebo, but there was no difference between amiodarone and placebo • Secondary endpoint data not yet reported

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