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Sudden Cardiac Death Syndrome

Sudden Cardiac Death Syndrome. Alexis Cortez-Bautista University of California, Merced. What is SCD?. SCD has a broad definition depending on who is studying it. Who does it affect.

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Sudden Cardiac Death Syndrome

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  1. Sudden Cardiac Death Syndrome Alexis Cortez-Bautista University of California, Merced

  2. What is SCD? • SCD has a broad definition depending on who is studying it

  3. Who does it affect Anyone can be affected by this disorder and is most of the time unexpected, however a group that has seem to be commonly affected is Athletes and active healthy people

  4. Risk Factors • Studies have shown that there are many risk factors that may contribute to Sudden Cardiac Death including • Congenital heart disease • Mutations in SQTS genes • Epilepsy

  5. Congenital Heart Disease • Hamilton, Leslie E., Lew,Emma O., Matshes, Evan W. (2011) ‘‘Grown-Up’’ Congenital Heart Disease and Sudden Death in a Medical Examiner’s Population. Journal of Forensic Sciences. 56:1206-1213 • Koyak, Zeliha. Harris, Louise,. de Groot,,Joris R., Silversides, Candice K., Oechslin,Erwin N., Bouma, Berto J., Budts, Werner., Zwinderman, Aeilko H., Van Gelder, Isabelle C., Mulder, Barbara J.M.(2012). Sudden Cardiac Death in Adult Congenital Heart Disease.Circulation. 1944-1954.

  6. Mutations • Lahtinen, Annukka M., Noseworthy , Peter A., Havulinna, Aki S., Jula, Antti , Pekka J. Karhunen, Kettunen, Johannes, Perola, Markus., Kontula, Kimmo, Newton-Cheh, Christopher.,Salomaa, Veikko. Common Genetic Variants Associated with Sudden Cardiac Death: The FinSCDgen Study. PLOS ONE. 7.7:1-7 • Wisten, Aase., Bostrom, Ida Maria., Morner, Stellan., Stattin, Eva Lenna. (2012) Mutation analysis of cases of sudden unexplained death, 15 years after death:Prompt genetic evaluation after resuscitation can save future lives. Resuscitation. 83:1129-1234

  7. Epilepsy • Bardai, Abdennasser., Lamberts, Robert J., Blom, Marieke., Spanjaart, Anne M., Berdowski Jocelyn., van der Staal, Sebastiaan R., Brouwer, Henk J., Koster, Rudolph W., Sander, Josemir W., Thijs Roland D., Hanno L. Tan. (2012) Epilepsy Is a Risk Factor for Sudden Cardiac Arrest in the General Population. Plos one. 7.8:1-5

  8. Approaches • Because this disorder is so spontaneous, the most common approach to study this disorder is through retrospective observations • There might be an advantage to performing research on people with the risk factors

  9. Screenings • Screenings using ECG have the potential to identify changes in the heart that could lead to SCD

  10. Questions

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