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Explore how the application of International Health Regulations (IHR) to Antimicrobial Resistance (AMR) events can help preserve antimicrobials. Discover why the IHR should be used to combat the global AMR threat and the challenges in implementation.
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Can the Application of the International Health Regulations to Antimicrobial Resistance Events Help to Preserve Antimicrobials? AMR 1, abstract N° 406 Didier Wernli, Thomas Haustein, John Conly, Stephan Harbarth Service prévention et contrôle de l‘infection Hôpitaux Universitaires de Genève
Background (1) • Legal framework for international effortsto contain the risk from public health threats that may spread between countries • scope not limited to a list of diseases, but covering “illness or medical condition, irrespective of origin or source, that presents or could present significant harm to humans” • Adopted by WHA in 2005, entered into force 2007 • 194 states parties + WHO as “hub” .
Background (2) • States Parties to develop certain minimum core public health capacities • States Parties to notify WHO of significantpublic health events • At the request of a State Party, WHO shall collaborate in the response […] by providing technical guidance and assistance (Art. 13.3) .
Background (3) – Notification • All events which may constitute a public health emergency of international concern (PHEIC) within its territory (≥2 x yes to the following questions) • Is the public health impact of the event serious? • Is the event unusual or unexpected? • Is there a significant risk of international spread? • Is there a significant risk of international travel or trade restrictions? • DG to determine whether event constitutes a PHEIC[this has happened once so far: H1N1 2009] .
Are AMR events notifiableunder the IHR? Example: International spread of“new” types of resistancecarbapenem-resistantEnterobacteriaceae .
Are AMR events notifiableunder the IHR? • At least 3 of the 4 criteriacouldbeaffirmed • If theycould, shouldthey? .
Why should the IHR be applied to the global AMR threat? • AMR requires a coordinated international response. • “wake-up call” to strengthen global AMR surveillance and response • early warning system: allow early implementation of screening measures and prevent the establishment of new resistant strains • societalinvestment in core surveillance and response capacities at different levels by setting minimum standards .
Outlook • IHR ultimately “owned” by the States Parties • WHO to provide leadership on the role of the IHR for combating AMR • Many practical obstacles for realizing the full potential of the IHR • Window of opportunity for an open debate about the applicability of the IHR to AMR. .
Thank you! PLoS Med. 2011 Apr;8(4):e1001022. .