Day 1 lecture “clean-up” issues

1. Day 1 lecture “clean-up” issues

2. What’s wrong with social epi? • Kaplan • Poor theory • Individual focus • Risk-factor thinking • Interdisciplinarity • Berkman • Too few experiments • Poor experimental results

3. What Causes Disease? God Germs Individual Choice & Behavior Market (failures) Social Norms Discrimination Policy Government Failures Social Forces

4. What Causes Disease? D Social Forces Markets Norms Racism; Sexism Physiology Molec. Bio. Genetics Germs Behavior Life-Style Choice Cause of Disease Fundamental/Upstream Immediate/Proximal

5. Oakes, JM. 2005. "An Analysis of AJE Citations with Special Reference to Statistics and Social Science." AJE 161:494-500.

8. Methodological challenges? • i) Outcome measure? • ii) Proximity = Exposure? • iii) Exposure = Disease? • iv) Social stratification • v) Multilevel phenomena

9. Group: time 1 Group: time 2 Individual: time 2 Individual: time 1 v) Multilevel phenomena Source: Oakes JM, JS Kaufman. 2006. "Introduction: Advancing methods in social epidemiology." Pp. 1-18 in Methods in Social Epidemiology, edited by Oakes and Kaufman. San Francisco: Jossey-Bass / Wiley.

10. 3) Counterfactuals or Potential Outcomes Model or Rubin’s Model

11. Idea comes from philosopher David Hume (1711-1776) • “…but for…” • Advanced by philosopher David Lewis in 1973 • “If kangaroos had no tails, they would topple over…” • Statistician Don Rubin advanced ideas in statistics and epi • Potential outcomes model • Recent work takes “closet possible world” assumption seriously • Just what are limits to comparative inference?

12. Ideal is to compare same unit under two scenarios; difference in outcomes is causal effect attributable to scenario. Let’s compare Ivan (and only Ivan) in environment with and without McDonalds, with all else exactly the same. Difference in Ivan’s BMI is effect of McDonald’s on Ivan. Trouble is, we cannot observe Ivan under both scenarios. Ivan either lives in an environment with McDonalds or he doesn’t. The scenario which Ivan does not actually live in is counter to fact, or the counterfactual. Rubin calls same the “potential outcome for Ivan.” In order to have actual data, we must find a substitute for Ivan’s unobservable counterfactual state. Finding a credible counterfactual substitute is the crux of all sound causal inference. In fact, randomization to condition is nothing more than technique to generate credible counterfactual substitutes.

14. Since we cannot observe BLACK under both scenarios, we substitute BLUE for the unexposed scenario.

15. ? BLACK Exposed Observed BLACK Unexposed Counterfactual BLUE Unexposed Counterfactual Substitute If BLUE is a perfect substitute for BLACKbut for the exposure (ie, unexposed BLACK), then causal inference is credible. To extent BLUE is NOT a perfect substitute for BLACK but for the exposure, we have bias or confounding. Background differences complicates inference.

16. So causal inference is all about finding the best counterfactual substitute for the unobservable counterfactual scenario. The best ones are said to be exchangeable. Randomization is a good mechanism to produce a group of subjects that are exchangeable. Simply, it’s all about the comparison group!

17. Agent-based Models Computer simulation to advance theory/concepts See Auchinloss & Diez Rouz. In Press. American J Epidemiology • Methodological individualist • Nonlinear • SUTVA not an issue • Different kind of explanation • But not empirical…