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Group 3

Group 3. Members of the group : Syamimi bt. Haslan (A 127285) Muhammad Jefri bin Mohd Yusof (A 127105) Noor Khairatul Azni bt Mat (A 127222) Chai Lee Chin (A 129966) Yosmetha a/p Mayalvanan (A 126816). JACOB’S SYNDROME. What is Jacob’s Syndrome?.

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Group 3

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  1. Group 3 Members of the group : Syamimi bt. Haslan (A 127285) Muhammad Jefri bin Mohd Yusof (A 127105) Noor Khairatul Azni bt Mat (A 127222) Chai Lee Chin (A 129966) Yosmetha a/p Mayalvanan (A 126816)

  2. JACOB’S SYNDROME.

  3. What is Jacob’s Syndrome? • A rare chromosomal disorder that affects males. It is caused by the presence of an extra Y chromosome. Males normally have one X and one Y chromosome. However, individuals with Jacob's syndrome have one X and two Y chromosome. • Males with Jacob's syndrome, also called XYY males.

  4. JACOB’S SYNDROME.

  5. Explanation. • XYY syndrome is an aneuploidy of the sex chromosomes in which a human male receives an extra Y chromosomes, giving a total of 47 chromosomes instead of the more usual 46. This produces a 47, XYY karyotype.

  6. Chemical Signs Of Jacob’s Syndrome High level of testosterone 2. Have 47 chromosomes, XYY karyotype 3. Delayed emotional maturity

  7. Physical Symptoms Of Jacob’s Syndrome • Large hand and feet • Skeletal malformation • Slightly taller than average • Having more severe acne than normal • Learning problems at school • Speech problem • Normal sexual libido and potency • Swollen joints • Joints stiffness • Arthritis • Camptodactyly • Impaired joint mobility • Inflammed pericardium • Chest pain

  8. What causes this disease? • It is not inherited • Occurs as a random event during the formation of sperm cells. • Error in chromosome separation during anaphase II (of meiosis II) called nondisjunction can result in sperm cells with an extra copy of the Y chromosome. If one of these atypical sperm cells contributes to the genetic makeup of a child, the child will have an extra Y chromosome in each of the body's cells.

  9. continue… • In some cases, the addition of an extra Y chromosome results from nondisjunction during cell division during a post-zygotic mitosis in early embryonic development. This can produce 46, XY/47, XYY mosaics.

  10. How common is the disease?. • About 1 in 1,000 boys are born with a 47, XYY karyotype. The incidence of 47, XYY is not affected by advanced paternal or maternal age. • In Malaysia, when the population of the male is about 12,751.9 million, the number of those who are affected to this disease is 11,761. This is about 0.09%.

  11. Thank You.

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