1 / 4

Osteoscoop - Issue N°298 – July 2013

Parathyroid hormone (1-34) counteracts the glucocorticoid-induced suppression of Interleukin-11 in osteoblasts. Osteoscoop - Issue N°298 – July 2013. Mature osteoblasts. Preosteoblasts. + Glucocorticoid excess (GC). IL-11. Low bone formation. Low osteoblast maturation

adlai
Download Presentation

Osteoscoop - Issue N°298 – July 2013

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Parathyroid hormone (1-34) counteracts the glucocorticoid-induced suppression of Interleukin-11 in osteoblasts Osteoscoop - Issue N°298 – July 2013

  2. Mature osteoblasts Preosteoblasts + Glucocorticoidexcess (GC) IL-11 Lowbone formation Lowosteoblast maturation High osteoblastapoptosis Low IL-11 expression

  3. Mature osteoblasts Preosteoblasts + Glucocorticoidexcess (GC) IL-11 Lowbone formation Lowosteoblast maturation High osteoblastapoptosis Low IL-11 expression GC + PTH(1-34) FosB DFosB Higherbone formation IL-11 Osteoblast maturation Osteoblastapoptosis Higher IL-11 expression

  4. Mature osteoblasts Preosteoblasts + Glucocorticoidexcess (GC) IL-11 Lowbone formation Lowosteoblast maturation High osteoblastapoptosis Low IL-11 expression GC + PTH(1-34) FosB DFosB Higherbone formation IL-11 Osteoblast maturation Osteoblastapoptosis Higher IL-11 expression PTH(1-34) GC Pkcd DFosB DFosB JunD JunD GR Smad1 Smad1 P P IL-11 Nucleus

More Related