MW 11:00-12:15 in Redwood G19 Profs: Serafim Batzoglou, Gill Bejerano TA: Cory McLean

MW 11:00-12:15 in Redwood G19 Profs: Serafim Batzoglou, Gill Bejerano TA: Cory McLean http://cs273a.stanford.edu [Bejerano Aut07/08]

Lecture 13 • Insulators in the Human Genome • Regulatory Potential http://cs273a.stanford.edu [Bejerano Aut07/08]

Insulators: A Reminder http://cs273a.stanford.edu [Bejerano Aut07/08]

CTCF [Ohlsson et al., 2001] http://cs273a.stanford.edu [Bejerano Aut07/08]

The Glass Ceiling [Ohlsson et al., 2001] http://cs273a.stanford.edu [Bejerano Aut07/08]

ChIP-chip reminder http://cs273a.stanford.edu [Bejerano Aut07/08]

Breaking the Glass Ceiling [Kim et al., 2007] http://cs273a.stanford.edu [Bejerano Aut07/08]

A known locus http://cs273a.stanford.edu [Bejerano Aut07/08]

More & less interesting correlations http://cs273a.stanford.edu [Bejerano Aut07/08]

Outliers http://cs273a.stanford.edu [Bejerano Aut07/08]

Consensus! http://cs273a.stanford.edu [Bejerano Aut07/08]

Not all are captured http://cs273a.stanford.edu [Bejerano Aut07/08]

From in vitro to in silico [Xie et al., 2007] http://cs273a.stanford.edu [Bejerano Aut07/08]

http://cs273a.stanford.edu [Bejerano Aut07/08]

Predicting Distal Elements http://cs273a.stanford.edu [Bejerano Aut07/08]

ChIP-Seq http://cs273a.stanford.edu [Bejerano Aut07/08]

Example: NRSF http://cs273a.stanford.edu [Bejerano Aut07/08]

With original motif http://cs273a.stanford.edu [Bejerano Aut07/08]

Pancreatic Islet beta cell-specification GRN http://cs273a.stanford.edu [Bejerano Aut07/08]

… http://cs273a.stanford.edu [Bejerano Aut07/08]

MW 11:00-12:15 in Redwood G19 Profs: Serafim Batzoglou, Gill Bejerano TA: Cory McLean