Conducting Stem Cell Research: Requirements and Application Procedures

1. Conducting Stem Cell Research: Requirements and Application Procedures Presented by: UCONN STEM CELL INSTITUTE OFFICE OF RESEARCH AND SPONSORED PROGRAMS (UCHC) OFFICE FOR SPONSORED PROGRAMS (STORRS) Application Deadline: January 14, 2011, 4:30PM December 2010

2. Types of Proposals • Seed Grants $200,000 (including indirect costs) for 2 years. • Established Investigator $750,000 (including indirect costs) for up to 4 years. • Core Grants $2.5Million (including indirect costs) for up to 4 years.

3. Types of Proposals (continued) • Group Projects a. Disease Directed Collaboration Project $2Million (including indirect costs) for up to 4 years. b. Group Project $1.5Million (including indirect costs) for up to 4 years. Please note: The Disease Collaboration Group Project is new this year and will be given priority over the “regular” group project.

4. Common Abbreviations and Websites SCRO = Stem Cell Research Oversight CommitteehESC = Human Embryonic Stem Cell iPSCS = Induced Pluripotent Stem Cells CI = Connecticut Innovations • Website of Applicationhttp://www.ctinnovations.com/about/2011 RFP Final.pdf • SCRO Websitehttp://www.escro.uconn.edu • Audrey ChapmanChair, SCRO Committeeachapman@uchc.edu

5. Application Components 5. Evidence of Commitment 6. Biographical Sketches 7. Budget (Attachment III) 8. Special Considerations 9. Appendix 1. Cover Page (Attachment I) 2. Project Summary (Attachment II) 3. Table of Contents 4. Project Description A. Project Objectives and Significance of Proposed Work B. Project Plan C. Intellectual Property D. Bibliography

6. 4.c. Intellectual Property The following statement was provided by the Center for Science and Technology Commercialization (CSTC) and suggested to be included in all UConn applications: “Per University of Connecticut policy, any invention, whether patentable or not, developed during the course of this project will be disclosed to the University’s Center for Science and Technology Commercialization, which oversees patenting and licensing for the University.”

7. 5. a. Commitment of Institution, Hospital or Company and other Collaborators UConn Letters of Commitment will be provided from 1. President Austin (must be included) 2. Ren-He Xu, Director, UConn Stem Cell Core Lab (optional) 3. Janet Hager, Director, Translational Genomics Core (optional) 4. H. Leonardo Aguila, Director, Flow Cytometry Facility (optional) For a copy of above letters to be included with your application contact the UConn Stem Cell Institute UCSCI_Admin@uchc.edu , OSP (Storrs), or ORSP (UCHC).

8. 5.c. Commitment to Sharing Resources 5.d. Financial Commitment from other Sources Examples of Possible Wording: 5c. Commitment to Sharing Resources Protocols, reagents and significant findings will be shared with the State of Connecticut Stem Cell Research Community. 5d.Financial Commitment from other Sources The requested budget is sufficient for the proposed outlined experiments.

11. IMPORTANT: • USE LAY LANGUAGE. • PROJECT SUMMARY WILL BE AVAILABLE TO THE PUBLIC. • DO NOT INCLUDE PROPRIETARY INFORMATION.

12. Plese be careful when preparing the budget strict rules about rebudgeting apply.

13. Attachment III Budget UCHC Applications Use Fringe Rates as listed on ORSP website: State Retirement 68% Alternate Retirement 38% Graduate Assistants/Foreign Nationals 20%

14. Attachment III BudgetUConn Storrs ApplicationsUse Fringe Rates as listed on OSP website:

15. Budget Justification • All budget items must be itemized with $ breakdown and explanation. • Personnel: use person months, list and justify all personnel; be careful with % effort for key personnel; any changes have to be approved by stem cell advisory committee NIH SALARY CAP DOES NOT APPLY. ACTUAL SALARY IS BEING USED. ALL COSTSHARE MUST BE APPROVED IN ADVANCE BY THE APPROPRIATE INSTITUTIONAL OFFICIAL. • Equipment: all items $1,000 and above.

16. Budget Justification (continued) • Materials and Supplies: itemize by category such as chemicals, reagents, disposables, etc. include a category for general supplies (if applicable) and list items such as; toner cartridges, paper, pens, etc. • Other: include items such as animal care, repair/maintenance, core services (translational core, stem cell core, facs), memberships, etc. • Travel: list as a separate line item, $5,000 max/per year • The following statement is suggested to be placed at the end of the budget justification: “Above costs were estimated based on current market pricing to achieve the milestones as described in the research plan”.

17. Budget: Subcontracts, Cost Share, and Indirect Cost • Subcontracts involving UCHC and Storrs, noadditional indirect cost will be charged on first $25,000 of sub grantee costs. • Subcontracts to all other entities (academic or commercial) are subject to 25% indirect cost on the first $25,000 of the total budget. • Please remember all subcontracts are limited to Connecticut unless extraordinary circumstances apply and prior approval was granted.

18. Budget: Subcontracts, Cost Share, and Indirect Cost (continued) • All cost-sharing must be approved before submission to ORSP/OSP (by Dr. Lalande at UCHC and Department Head/Dean/Provost at Storrs).

19. Seed Grants/Postdoctoral Fellows • Proposal must include a Letter of Support and Biosketch from the Faculty Sponsor(s). The sponsor’s letter must address the following • The post-doc's faculty mentor agrees in writing to commit the resources necessary for the project; • The post-doc's mentor agrees to assume full responsibility for completion of the project; for its orderly close-out/termination, including (but not limited to) responsibility for all reporting requirements; removal of hazardous/controlled substances that the post-doc may have left behind; arranging for euthanasia of animals left behind • The mentor agrees to assume responsibility for serving as PI on IRB/ACC applications, and the responsibilities associated with such status, e.g., reports, follow-up, etc.

20. Proposal Format • Pages numbered at the bottom • One-inch margins • 12 pointfont • Single-spaced • Printed on one side only • Any reprints, appendices, or other materials to be considered with the proposal must be attached to the original proposal. • Proposal and all attachments should be sent in one (1) PDF file.

21. Proposal Routing • Stem Cell proposals require completion of two routing forms (internal only, do not include with electronic submission to CI). • The first routing form is the standard ORSP/OSP form used for all grants. • The second routing form is the Supplemental Routing Form for Proposals Involving the Use or Creation of Human Stem Cells (UCHC)/Attachment for Human Stem Cell Research (Storrs). The respective form must accompany all stem cell applications. It can be downloaded from the ORSP/OSP websites. (http://orsp.uchc.edu/forms/index.html; http://www.osp.uconn.edu/forms.php#uconn)

22. Routing Continued • July 1, 2011 is the proposed start date. This is an estimated date. • Funded grants will not get awarded until all approvals are in place and CT Innovations receives final SCRO approval. • For the submission of the application SCRO, IRB, ACC, IBC approvals are not needed and can be listed as pending.

23. Submission • ORSP/OSP recommend to start the routing process no later then the week of January 3, 2011. • Due Date: Friday, January 14, 2011, 4:30PM • One signed electronic PDF copy to: stemcellinfo@ctinnovations.com • To be submitted by the investigator (Please copy UCSCI_Admin@uchc.edu, orsp@uchc.edu, Antje.Harnisch@uconn.edu as part of the submission)

24. CONTACTS FOR ADDITIONAL QUESTIONS IN REGARDS TO THE APPLICATION: Chelsey Sarnecky Connecticut Innovations Direct phone: 860-257-2355 E-mail: stemcellinfo@ctinnovations.com and ORSP, OSP and UConn Stem Cell Institute