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Drug Resistance Surveillance

9/27/2012. MDR TB, INCLEN. 2. Anti-TB Drug Resistance in the World. Definition of resistance: ? A decrease in sensitivity to sufficient degree to be reasonably certain that the strain concerned is different from a sample of wild stains of human type that have never come in contact with the drugs"

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Drug Resistance Surveillance

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    1. 9/27/2012 MDR TB, INCLEN 1 Drug Resistance Surveillance

    2. 9/27/2012 MDR TB, INCLEN 2 Anti-TB Drug Resistance in the World

    3. 9/27/2012 MDR TB, INCLEN 3 Anti-TB Drug Resistance in the World

    4. 9/27/2012 MDR TB, INCLEN 4 Earlier studies from India

    5. 9/27/2012 MDR TB, INCLEN 5 Reports on combined resistance and their limitations Case selection Sample size Methodology Source of drugs Definition of resistance

    6. 9/27/2012 MDR TB, INCLEN 6 Studies Reported From NTI & AFMC

    7. 9/27/2012 MDR TB, INCLEN 7

    8. 9/27/2012 MDR TB, INCLEN 8 Drug Resistant TB in Armed Forces Chest Disease Hospital, Pune (1995 – 99) No of pts.: 2562

    9. 9/27/2012 MDR TB, INCLEN 9 TRC Studies

    10. 9/27/2012 MDR TB, INCLEN 10 Drug Resistance on Admission in Pondicherry

    11. 9/27/2012 MDR TB, INCLEN 11 Drug Resistance on Admission in N Arcot Dt.

    12. 9/27/2012 MDR TB, INCLEN 12 Drug Resistance Survey in N Arcot Dt.

    13. 9/27/2012 MDR TB, INCLEN 13 Drug Resistance Survey in N Arcot Dt.

    14. 9/27/2012 MDR TB, INCLEN 14 Drug Resistance Survey in Raichur Dt.

    15. 9/27/2012 MDR TB, INCLEN 15 Drug Resistance Survey in Raichur Dt.

    16. 9/27/2012 MDR TB, INCLEN 16

    17. 9/27/2012 MDR TB, INCLEN 17 Prevalence of Primary Drug Resistance TRC Studies – (1974 -2001)

    18. 9/27/2012 MDR TB, INCLEN 18 Recent Reports From TRC On DRS based on WHO/IUATLD Guidelines

    19. 9/27/2012 MDR TB, INCLEN 19 WHO / IUATLD Global Project on Anti TB Drug Resistance Objectives To collect data on the Worldwide extent on the severity of anti-TB drug resistance in a standardized manner at a country level To monitor drug resistance levels in countries identified as a priority for assistance or in countries where, for various reasons, knowledge of drug resistance levels may be important for global policy decisions

    20. 9/27/2012 MDR TB, INCLEN 20 Summary of Patterns of Resistance

    21. 9/27/2012 MDR TB, INCLEN 21 Summary of Patterns of Resistance

    22. 9/27/2012 MDR TB, INCLEN 22

    23. 9/27/2012 MDR TB, INCLEN 23

    24. 9/27/2012 MDR TB, INCLEN 24 Surveillance of primary drug resistance N.Arcot dt,TN,1999

    25. 9/27/2012 MDR TB, INCLEN 25 Primary Drug resistance - NArcot . Dt, TN

    26. 9/27/2012 MDR TB, INCLEN 26 Surveillance in Drug Resistance, Raichur Dt, Karnataka,1999 -2000

    27. 9/27/2012 MDR TB, INCLEN 27 Surveillance in Drug Resistance Raichur Dt. Karnataka 1999 -2000

    28. 9/27/2012 MDR TB, INCLEN 28 PRIMARY DRUG RESISTANCE-RAICHUR

    29. 9/27/2012 MDR TB, INCLEN 29 Surveillance in Drug Resistance Wardha District Maharashtra 2000 -2001

    30. 9/27/2012 MDR TB, INCLEN 30 Primary drug resistance Wardha district

    31. 9/27/2012 MDR TB, INCLEN 31

    32. 9/27/2012 MDR TB, INCLEN 32 Primary resistance in the Model DOTS area (1999- 2003)

    33. 9/27/2012 MDR TB, INCLEN 33 Drug Resistance in HIV/TB (2000-02)

    34. 9/27/2012 MDR TB, INCLEN 34 Recent reports from NTI

    35. 9/27/2012 MDR TB, INCLEN 35

    36. 9/27/2012 MDR TB, INCLEN 36 Primary Drug Resistance – NTI studies 2003

    37. 9/27/2012 MDR TB, INCLEN 37 Other Reports on ADR

    38. 9/27/2012 MDR TB, INCLEN 38 ADR- MDR TB - INDIAN STUDIES

    39. 9/27/2012 MDR TB, INCLEN 39 ADR-MDR TB-TRC RESULTS

    40. 9/27/2012 MDR TB, INCLEN 40 Anti-TB Drug Resistance in the World

    41. 9/27/2012 MDR TB, INCLEN 41 EVOLUTION OF THE GLOBAL PROJECT ON DRS (WHO/IUATLD & OTHER PARTNERS)

    42. 9/27/2012 MDR TB, INCLEN 42 DEVELOPMENT OF SRLN

    43. 9/27/2012 MDR TB, INCLEN 43 PROGRESS OF THE GLOBAL PROJECT ON DRS

    44. 9/27/2012 MDR TB, INCLEN 44 PROGRESS OF THE GLOBAL PROJECT ON DRS

    45. 9/27/2012 MDR TB, INCLEN 45 THIRD PHASE GLOBAL DRS 1999-02

    46. 9/27/2012 MDR TB, INCLEN 46 THIRD PHASE : GLOBAL DRS 1999-02

    47. 9/27/2012 MDR TB, INCLEN 47 WHO/IUATLD GLOBAL PROJECT 1999-2002

    48. 9/27/2012 MDR TB, INCLEN 48 WHO/IUATLD GLOBAL PROJECT 1999-2002

    49. 9/27/2012 MDR TB, INCLEN 49 DRS – Indonesia Primary Resistance % Year H R S E MDR 1996 1.3 5.2 2.9 - 5.8 1997 1.6 5.9 2.1 - 5.0 1998 5.4 1.7 5.4 0.9 6.6 PERSHABATAN HOSPITAL - JAKARTA

    50. 9/27/2012 MDR TB, INCLEN 50 DRS – Indonesia Secondary Resistance % Year H R S E MDR 1996 6.4 6.4 1.6 - 24.5 1997 6.0 5.8 0.7 - 41.8 1998 6.8 5.8 4.3 - 24.7 PERSHABATAN HOSPITAL - JAKARTA

    51. 9/27/2012 MDR TB, INCLEN 51 DRS – Few comments No evidence of an increase in the prevalence of primary resistance Reports on higher prevalence of ADR (Gujarat, N.Arcot, N.Delhi, Tamilnadu ,Bombay, UP.) Low level prevalence of MDR TB in TRC studies Paediatric cases low level resistance to H (5-10%) low level resistance to S (2-14%) absence of MDR TB Compared to global situation a lesser prevalence of primary resistance a much higher level of acquired resistance is observed

    52. 9/27/2012 MDR TB, INCLEN 52 Anti-TB Drug Resistance in the World

    53. 9/27/2012 MDR TB, INCLEN 53 DRUGS USED FOR THE THERAPY OF MYCOBACTERIAL INFECTION

    54. 9/27/2012 MDR TB, INCLEN 54 Drug susceptibility testing

    55. 9/27/2012 MDR TB, INCLEN 55 Antimicrobial susceptibility tests

    56. 9/27/2012 MDR TB, INCLEN 56 MOLECULAR BASIS OF DRUG RESISTANCE

    57. 9/27/2012 MDR TB, INCLEN 57 FACTORS ASSOCIATED WITH MDR TB

    58. 9/27/2012 MDR TB, INCLEN 58 RAPID DETECTION OF DRUG RESISTANT STRAINS

    59. 9/27/2012 MDR TB, INCLEN 59 RAPID DETECTION OF DRUG RESISTANT STRAIN

    60. 9/27/2012 MDR TB, INCLEN 60 Cost: MODS versus other methods

    61. 9/27/2012 MDR TB, INCLEN 61 Comparisons of turnaround-time

    62. 9/27/2012 MDR TB, INCLEN 62 What is feasible in DEC?

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