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BDNF. TRKB. GRB2. GAB1. PI3K. MEK1/2. Raf1. Akt. RSK. BAD. BCLXL. P. P. P. P. P. P. P. I P 3 R. 14-3-3. ERK1/2. SHC. SOS. BAD. Ca 2+. Ca 2+. Ca 2+. CREB. CREB. BCL2. Ras. BDNF Pathway. PLC γ. DAG. PKC Pathway. IP3. Cell Adhesion and Migration. Cell Survival.
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BDNF TRKB GRB2 GAB1 PI3K MEK1/2 Raf1 Akt RSK BAD BCLXL P P P P P P P IP3R 14-3-3 ERK1/2 SHC SOS BAD Ca2+ Ca2+ Ca2+ CREB CREB BCL2 Ras BDNF Pathway PLCγ DAG PKC Pathway IP3 Cell Adhesionand Migration Cell Survival Synaptic Plasticity and Neurogenesis Gene Expression