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Industrial Pharmaceutical Size Enlargement

Industrial Pharmaceutical Size Enlargement. Faculty of Pharmacy OCTOBER 6 University. AGGLOMERATION. The increase of PS combined with change in product shape . The action or process of gathering particulate matter in a conglomerate.

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Industrial Pharmaceutical Size Enlargement

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  1. Industrial Pharmaceutical Size Enlargement Faculty of Pharmacy OCTOBER 6 University

  2. AGGLOMERATION • The increase of PS combined with change in product shape . The action or process of gathering particulate matter in a conglomerate. APPLICATION :1- No or low content of dust (safety) . 2- Increase bulk density & lower bulk volume. 3- Free flowing powder. 4- Defined shape & improve product appear . 5- improved metering & dosing capabilities .

  3. EQUIPMENT & PROCESSES • Mechanisms applied to build agglomerates utilizing tumble & pressure agglomeration . • TUMBLE AGGLOMERATION : • Growth occurs after addition of liquid binders. Apparatus used are the balling disc , balling cone , & balling drum . • Mechanism : equipment rotates around its axis & a liquid binder is sprayed into the moving bed. • Agglomerates are built up during tumbling ,rolling & sliding .

  4. Tumble can be used in case of batch or continuous mixers. Powder & binder are fed into the fluidized bed. If fluidized gas is hot drying takes place . • PRESSURE AGGLOMERATION : • Very high force acting on a mass of particulate matter within defined volume. • No binders only a few dry or liquid binders & or lubricant .

  5. P AGG used in piston, roller, isostatic , & extrusion presses & pelleting machines . • Presses operate either mechanically or hydraulically . • Materials is densified in dies by oscillating pistons or shaped by reciprocating from halves . • In roller press, two rollers of equal size with smooth surface , rotate counter-currently . • In table ting . Two types of machines , the excenter press & the tablet press.

  6. OTHER SIZE EP • SINTERING : formation of agglomerate by heating exp. Formation of iron pellets . • SPRAY DRYING : hollow spheres from in the drying tower from dissolved or susp material , exp spray dried milk & spray dried lactose .

  7. MICROENCAPSULATION • PACKAGING METHOUD ; small portions of liquids, powder, agglomerates or even gases are wrapped into shell to form more or less spherical particles . • Additive to improve handling , taste & release characteristics . • Coacervation property, PPT Of colloid material by means of an electrolyte or another colloid polymeric material of opposite charge . • Simple coacerv. PPT of gelatin by sod. Sulphate , complex coacerv. PPT of gelatin with gum acacia

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