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Speaker: Szu-Wei Huang

Speaker: Szu-Wei Huang. Tf: transferrin. DFO: deferoxamine. Deferoxamine enhances V. vulnificus growth. Clinical isolates. Enviromental isolates. The presence of deferoxamine under iron-limited condition induces desA expression. NL-HI: Normal heart infusion broth

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Speaker: Szu-Wei Huang

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  1. Speaker: Szu-Wei Huang

  2. Tf: transferrin

  3. DFO: deferoxamine

  4. Deferoxamine enhances V. vulnificus growth Clinical isolates Enviromental isolates

  5. The presence of deferoxamine under iron-limited condition induces desA expression NL-HI: Normal heart infusion broth DP: 200 mmole/L dipyridyl Df: deferoxamine DF-HI: deferrated HI broth CA: cirrhotic ascites

  6. Wild type desA mutation blocks the growth enhancement from deferoxamine PBS deferoxamine

  7. Deferoxamine can remove iron bound to tranferrin, especially MC and DF forms AP: apoferric transferrin MN: N’ terminal monferric transferrin MC: C’ terminal monoferric transferrin DF: diferric transferrin

  8. CMM2301: vulnibactin (siderophore) deficient strain Deferrated HI broth + partially iron-saturated transferrin (desA - ) (desA +) Cirrhotic ascites PBS deferoxamine

  9. ? desA mRNA

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