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Gene Silencing Model

Gene Silencing Model. Gene Silencing Model. Eukaryotic Cell. Gene Silencing Model. Unloaded dicers. Gene Silencing Model. BUT - If ds RNA enters cell. Unloaded dicers ignore ss RNA. Gene Silencing Model. Dicers recognise ds RNA. Gene Silencing Model.

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Gene Silencing Model

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  1. Gene Silencing Model

  2. Gene Silencing Model Eukaryotic Cell

  3. Gene Silencing Model Unloaded dicers

  4. Gene Silencing Model BUT - If ds RNA enters cell Unloaded dicers ignore ss RNA

  5. Gene Silencing Model Dicers recognise ds RNA

  6. Gene Silencing Model Dicers cleave ds RNA into 21 nt fragments

  7. Gene Silencing Model Loaded dicers transfer one 21 nt fragment to each RISC complex

  8. Gene Silencing Model Loaded dicers transfer one 21 nt fragment to each RISC complex

  9. Gene Silencing Model RISC complexes cleave ss RNA RISC complexes recognise complementary ss RNA

  10. Gene Silencing Model RNA destroyed and gene silenced!

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