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Early embryonic lethality of (PARP-1 +/- ; PARP-2 -/- ) females is associated

Early embryonic lethality of (PARP-1 +/- ; PARP-2 -/- ) females is associated with X chromosome instability. (PARP-1+/- ; PARP-2+/-). (PARP-1 +/- ; PARP-2 -/-). 2X. 4X + derX. 2X + derX. 1X + derX. • no instabilty in chromosomes 14 or 12 in (PARP-1 +/- ; PARP-2 -/- ) females

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Early embryonic lethality of (PARP-1 +/- ; PARP-2 -/- ) females is associated

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  1. Early embryonic lethality of (PARP-1+/- ; PARP-2-/-) females is associated with X chromosome instability (PARP-1+/- ; PARP-2+/-) (PARP-1 +/- ; PARP-2 -/-) 2X 4X + derX 2X + derX 1X + derX • no instabilty in chromosomes 14 or 12 in (PARP-1+/- ; PARP-2-/-) females • no X chromosome instability in (PARP-1+/- ; PARP-2-/-) males • no defect in X chromosome inactivation as detected with anti-macroH2A Ménissier - de Murcia et al. 2003, EMBO J. 22, 225

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