1 / 22

How Genomics is changing Business and Services of Associations

How Genomics is changing Business and Services of Associations. Dr. Josef Pott, Weser-Ems-Union eG, Germany. Associations. Member owned and directed Purpose: improve the Holstein breed Collect and analyze data and provide information and services to members.

ajaxe
Download Presentation

How Genomics is changing Business and Services of Associations

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. How Genomics is changing Business and Services of Associations Dr. Josef Pott, Weser-Ems-Union eG, Germany

  2. Associations • Member owned and directed • Purpose: improve the Holstein breed • Collect and analyze data and provide information and services to members

  3. Business activities of associations • Core services: • Registration • Shows • Classification • Other services: • Milk recording • Genetic evaluation and/or genotyping • A. I.

  4. Genomic Selection • Based on DNA sequences • - Genotyping of large number SNPs on low costs • Allows tracking the inheritance of short chromosomal segments • - Reference population: SNPs linked to EBVs of progeny proven bulls - - essential: verified parentage, good and complete data

  5. Genomic EBVs • Reliability:parent average < genomic EBVs < progeny proven EBVs • Earlier available=> decreasing the generation interval • Obtain acceptance by validation

  6. gEBV – validation in Germany(S. Rensing, vit 2012) progeny proof conformation, RZE production, RZM • 962 validation bulls – December 2010 – no daughter information • August 2012: at least a second daughter based proof Total Performance Index, RZG SCC, RZS gEBV

  7. Use of genomic bulls in Germany(Jan 2011 – May 2012, Rensing, vit 2012) regional differences: 20 % to 75 %

  8. LD-chip • LD-predictions: roughly 95% as accurate as predictions from the 50 k chip • Gained popularity due to lower price => testing females • More accurate and earlier information than parent average - production - conformation - productive life - SCC - calving ease - fertility - inbreeding and genetic defects

  9. Impact of Genomics on: • classification • progeny testing

  10. Objectives of classifications • Improve functional conformation - workability • - resistance to diseases - longer lifetime - natural ability to produce milk • Can enhance the value of an animal • Type EBVs

  11. Factors influencing the functional conformation/value of an animal

  12. Reliabilities of parent average and gEBVsvit 2009 gEBVs are of greater value than individual production records or classifications Genomic testing of females can reduce # of classifications

  13. How will progeny testing be affected? # young bulls entering AI in Germany (2011) (vit, 2012) - # of progeny groups is decreasing - Total # of inspected daughters is decreasing=> less progeny proven bulls/year in reference population - - increasing # of daughters/bull (?) – bias! => classification in representative sample herds

  14. Basic conditions of dairy farming • Decreasing # of farms • Increasing herd sizes • Farmers are: more progressive, less traditional, always short of time • Growing demand for services •  simple, complete solutions

  15. Genomic services • Genomic testing (i.e., different types of SNP panels) • Parent verification/identification • Replacement management • Improved mating service

  16. Genomic testing and parent verification Genomic testing (LD, 50K, HD) • EBVs for all traits • Parent verification- currently: DNA-micro satellite technology (animal itself + dam + sire required)- in future: SNP technology to confirm parentage for Herdbook validation all potential parents must be tested one sample for – genomic testing - parentage verification - genetic recessives - coat colour

  17. GENOID – Holstein Canada • Genomic testing and creating a record in the Herdbook in one step for non registered animals • Genomic EBVs • AI sires and previously genotyped dams will be identified • Registration confirmation and gEBVs to owner

  18. Genomic testing of females;replacement management • Low costs of genotyping required;to test all heifers is profitable at € 29; attractive at € 15 (Pryce et al. 2012) • Cost effective in particular- if pedigree information is unavailable(if pedigree information is available pre-sort animals based on pedigree data)Weigel (2011) - if available heifers exceeding replacement needs (sexed semen)

  19. Genomic testing of females; replacement management Applications: • Selection among heifer calves or springing heifers • Mating • Evaluation of elite females • Screening prior to purchase • Manage animals more individually

  20. Improved mating service • Up to now:based on production, pedigree,physical assessment • Now: based on genomic EBVs • Higher reliabilities for all traits • Avoid inbreeding • Deal adequate with recessives • Enhance genetic progress

  21. Conclusions • Genomic selection is widely introduced • gEBVs are gaining acceptance • Decreasing # of bulls entering AI • Female genotyping is getting popular • Threats: less classifications? + less progeny testing • Opportunities: genomic service

More Related