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Means ± SD

DIETARY SODIUM INTAKE MODULATES RESPONSIVENESS OF DIASTOLIC FUNCTION TO ANGIOTENSIN II IN NORMAL HEALTHY INDIVIDUALS Jonathan S Williams 1 , Scott D. Solomon 2 , Marina Crivaro 2 , Marie Gerhard-Herman 2 , Paul R Conlin 1

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Means ± SD

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  1. DIETARY SODIUM INTAKE MODULATES RESPONSIVENESS OF DIASTOLIC FUNCTION TO ANGIOTENSIN II IN NORMAL HEALTHY INDIVIDUALS Jonathan S Williams1, Scott D. Solomon2, Marina Crivaro2, Marie Gerhard-Herman2, Paul R Conlin1 1Division of Endocrinology, Diabetes and Hypertension, and 2Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Means ± SD Figure 2. Effect of dietary sodium on diastolic function (Ea) and blood pressure (SBP). Note: Diastolic function improves despite increase in blood pressure. LS = Low sodium; HS = High sodium Figure 3. Proposed mechanisms of RAAS involvement in diastolic function. Upper panel: Teleologic basis for altered function; Lower panel: Interplay of Ang II and dietary sodium on diastolic function Figure 3. Effect of dietary sodium on responsiveness of diastolic function (Ea) to Ang II infusion.

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