crystallizers supplier

1. Freeze Drying vs Spray Drying: Is It Necessarily Quality vs Cost?  In an industry where productivity and profitability are becoming increasingly important, difficult decisions must be made from time to time, as evidenced by the debate over whether to use spray drying or freeze-drying when developing a product process, and it can come down to something as uncomplicated as overhead costs. Alaqua is a spray dryer supplier worldwide based in the US. In order to assist you to decide which is ideal for your project and product, we've weighed the benefits of each. www.alaquainc.com

2. Which One to Choose? When liquid stability is inadequate, storage requirements are too severe, or a solid form of the product is sought, freeze-drying is generally recognized in the biopharmaceutical sector as the optimum approach for preserving a wide range of pharmaceutical formulations. While freeze-drying is the most widely used drying method for a number of materials with varying degrees of sensitivity, research has been conducted to study alternate ways, such as spray drying, due to the costs and often large quantities associated with the approach . Spray drying, despite being new to the industry, has several advantages, such as the capacity to operate with higher throughput (more continuous than batch) and scalable volumes, making it a feasible alternative for lyophilization , but only in particular circumstances. www.alaquainc.com

3. Process of Drying Freeze drying works by freezing a product first, generally in a controlled manner to alter the ice crystal structure, and then placing it in a vacuum to remove the unbound water. The material is then subjected to secondary drying, which reduces the material's remaining moisture to a user-defined level. Given that the goal at this point is bound rather than unbound/free water, more energy is necessary to accelerate the process by elevating shelf temperatures to +20°C or higher, along with low air pressure, enabling ice to convert straight into water vapor (bypassing the liquid phase). www.alaquainc.com

4. Industry Usage Both processes have a wide variety of applications. Freeze drying is commonly used to preserve various fine chemicals/laboratory reagents, cell types, injectable vaccinations, as well as dairy and food products. This processing method is best suited for formulations that do not require further processing after drying, as it is typically performed with product directly filled in vials or other containers; additionally, avoiding potential contamination after the cycle is complete, vials can be sealed in-situ of the lyophilized. www.alaquainc.com

5. Quality, Efficiency, and Cost Furthermore, freeze drying's strength is in the consistent quality of the output. Low processing temperature accuracy reduces the possibility of inherent product features including eutectic melt, collapse, and glass transition temperatures being surpassed, resulting in high-quality freeze-dried goods. The shear stress that biopharmaceuticals are subjected to during spray drying when paired with the high processing temperatures necessary, can destabilize molecules like proteins and impair product characteristics, resulting in a reduction in product quality, according to research. Alaqua is processing equipment such as the evaporator, crystallizer, heat exchanger, distillation equipment, solvent recovery, and spray dryer supplier worldwide based in the USA. www.alaquainc.com

6. Thank you ! Address- Alaqua 7004 Boulevard East, Suite 28A,Guttenberg, NJ USA 07093 Mail id - alaquainc1@gmail.com Website - https://www.alaquainc.com