1 / 8

Drugs for Peptic Ulcer Disease

Chapter 73. Drugs for Peptic Ulcer Disease. Drugs for Peptic Ulcer Disease. Peptic ulcer disease Upper GI disorders Degrees of erosion of the gut wall Cause Imbalance between mucosal and aggressive factors. Defensive factors Mucus Bicarbonate Blood flow Prostaglandins.

albina
Download Presentation

Drugs for Peptic Ulcer Disease

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Chapter 73 Drugs for Peptic Ulcer Disease

  2. Drugs for Peptic Ulcer Disease • Peptic ulcer disease • Upper GI disorders • Degrees of erosion of the gut wall • Cause • Imbalance between mucosal and aggressive factors

  3. Defensive factors Mucus Bicarbonate Blood flow Prostaglandins Aggressive factors Helicobacter NSAIDs Gastric acid Pepsin Smoking Pathogenesis of Peptic Ulcers

  4. Classes of Antiulcer Drugs • Antibiotics • Antisecretory agents • Mucosal protectants • Antisecretory agents that enhance mucosal defenses • Antacids

  5. Helicobacter pylori • Test: breath test or serum • Treatment—(two antibiotics are prescribed) • Bismuth • Clarithromycin • Amoxicillin • Tetracycline • Metronidazole

  6. Histamine-2 Receptor Antagonists • Cimetidine (Tagamet) • Ranitidine (Zantac) • Ranitidine bismuth citrate (Tritec) • Famotidine (Pepcid) • Nizatidine (Axid)

  7. Proton Pump Inhibitors • Omeprazole (Prilosec) • Inhibits gastric secretion • Short half-life • Used for short-term therapy • Adverse effects • Headache • Gastrointestinal

  8. Sucralfate (Carafate) • Protective barrier up to 6 hours • Uses • Acute ulcers • Adverse effects • Constipation • Drug interactions

More Related