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Mechanisms of Disease Environmental/Nutritional/ Diseases of Infancy and Childhood June 17, 2003. Stephen L. Putthoff, D.O., FCAP Chairman, Department of Pathology and Anatomy. Table 10-3, pg. 409 Table 10-4, pg. 409. Don't smoke and tell your patients not to.
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Mechanisms of DiseaseEnvironmental/Nutritional/ Diseases of Infancy and ChildhoodJune 17, 2003 Stephen L. Putthoff, D.O., FCAP Chairman, Department of Pathology and Anatomy
Don't smoke and tell your patients not to. Don't smoke, and tell your patients not to
How much do you drink? • Do you have an alcohol problem? It might be useful if you reflected upon it • Do you have any friends who youthink have, or may have a predilection for alcohol abuse – but they seem oblivious?
Common OTC agents • Acetaminophen • Aspirin
Pollution • Outdoor • Indoor
Industrial exposures • Volatile organics • Halogenated hydrocarbons • Plastics, rubber and polymers • Metals • Table 20-12, pg. 421 Table 10-11, p 419
Effects of lead • Clinical manifestations?
DDT Diazanon Malathion Nicotine Arsenic Paraquat Warfarin Strychnine Pesticides
Natural Toxins Radiation Injury UV irradiation Physical Environment Wounding = E x 1/T x 1/A x k abrasion laceration contusion gunshot wounds characteristics, range, etc. entries exits
Physical Injury [cont’d] Thermal injuries burns hyperthermia hypothermia Electrical injuries Atmospheric pressure injury
Food and Nutrition • Nutritional deficiencies • Protein-energy malnutrition Kwashiorkor Marasmus Table 10-20, pg. 438
Vitamin deficiencies • Fat soluble • Water soluble Table 10-21, pg. 440 Deficiency states vs. toxicity
Vit. A vs. Vit. C vs Vit. D • A: Fig. 10-23, pg. 442 • Eye; xerophthalmia, etc. • D: Fig. 10-24, pg. 443 • rickets, osteomalacia • C: Fig. 10-30, pg. 451 • scurvy Others: beriberi, chelitis, pellagra, macrocytic anemia,acrodermatitis enteropathica,
Diet • High protein/low carbohydrate • Low protein • High carbohydrate • Basic principle: eat less, exercise more
Chemoprevention of cancer • ??????
Congenital malformations Perinatal infections RDS-newborn Erythroblastosis fetalis PKU Galactosemia Cystic fibrosis SIDS Neuroblastoma Wilms tumor Diseases of Infancy and Childhood