1 / 8

Voltage-dependent K+ channel beta subunit (W121A) in complex with cortisone 3EB3

Voltage-dependent K+ channel beta subunit (W121A) in complex with cortisone 3EB3. By Steven Shikhel. Shaker Family Voltage Dependent Potassium Channels . Denoted Kv1 Shaker Family because the Shaker (Sh) Gene plays a part in the role of the channel

aleta
Download Presentation

Voltage-dependent K+ channel beta subunit (W121A) in complex with cortisone 3EB3

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Voltage-dependent K+ channel beta subunit (W121A) in complex with cortisone 3EB3 By Steven Shikhel

  2. Shaker Family Voltage Dependent Potassium Channels • Denoted Kv1 • Shaker Family because the Shaker (Sh) Gene plays a part in the role of the channel • Shaker channel is voltage dependent and has four subunits which form a pore through which ions flow • Essential for cellular excitability 1QRQ- Beta Subunit

  3. Cortisone 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE PDN

  4. Cortisone • steroid hormone, C21 H26 O5 • increases activity by binding to Kv beta 1 subunits. This is important because loss of function causes hyperexcitability and this is linked with episodic ataxia and atrial fibrillation. • promotes dissociation of Kv beta subunits, dissociation of kv beta 1 should eliminate inactivation and thus promotes cellular excitability. C21 H26 O5

  5. NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUNADPH DIHYDRO- NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATECLEOTIDE NDPPHOSPHATE NDP

  6. NDP • Nothing specifically was said about NDP as it relates to the beta subunits • Most likely important in function of ion transport and structure since it is located centrally. C21 H30 N7 O17 P3

  7. N-terminus Amine • The N-terminus is start of protein terminated with free amine –NH2 • I first highlighted all amines in yellow and then found an amine on a terminal part and colored it cyan • I believe that the red arrow pointing at cyan color is the N-terminus • N-terminal segment closes channel by N-type inactivation mechanism

  8. The results found of Cortisone has launched a search to find other ligands that will fine tune cellular excitability

More Related