ISO 9001:2008 Certified U.S. Based Manufacturing Since 1928

1. Innovative Chemical Technology For Innovative Applications ISO 9001:2008 Certified U.S. Based Manufacturing Since 1928

2. Shipping/Receiving Columbus, OH Manufacturing Complex Leaders in Small Molecule Building Blocks

3. Why Source from GFS? • Manufacturer, since 1928 • ISO certified; non-cGMP • Depth and diversity of core product lines • Support for Research → Commercial volumes • Support for custom specifications and products Leaders in Small Molecule Building Blocks

4. Kilo Lab Scale Glassware up to 72 L scale Distillation support up to 50L scale Short path Bench Strip Rotary Evaporators Long path 18” to 48” packed columns Stainless, Hastelloy, Ceramic packing Equipment Capabilities and Scale(Organic Division) • Pilot Scale • 10 gal – 100 gal glass lined steel • 10 gal – 200 gal Stainless • Distillation Support • Rotary Evaporator • 30 gal – 50 gal glass lined steel distillation pots • 4’ to 12’ columns • Glass & stainless packing Leaders in Small Molecule Building Blocks

5. Plant Scale 350-500 gal Hastelloy 100-1000 gal Glass 200-1000 gal Stainless Distillation support Short path 50 gal-500 gal glass lined Long path 4’ to 16’ column Stainless, Hastelloy, Glass packing Solids Handling Hastelloy and Stainless centrifugation Equipment Capabilities and Scale(Organic Division) • Plant Scale Supports • Vacuum capabilities to < 10 Torr • Pressure handled to < 100 psi • Reaction conditions controlled from -40oC to +140oC • Distillation conditions controlled from 20oC to 250oC • Scrubbing supports for acid/base, ammonia and sulfide • Nitrogen used as inerting atmosphere Leaders in Small Molecule Building Blocks

6. Core Organic Technologies • Reactions in Liquid Ammonia • Acetylene Reactions • Alkyne Chemistry • Organometallic Chemistry (Mg, Li, Na) • Halogen Chemistry (Cl, Br, I) • Heteroaromatic Compounds Leaders in Small Molecule Building Blocks

7. Liquid Ammonia RC CH RC CR' RC CCCOH RNH2 NH3 Leaders in Small Molecule Building Blocks

8. Liquid Ammonia CCn Z n=2 to 7 R CCCN R NH3 Leaders in Small Molecule Building Blocks

9. Acetylene Reactions HC CR HC CC2OH HC CCnCl HC CCnC CH RC CC CCOH HC CH Leaders in Small Molecule Building Blocks

10. Alkyne Chemistry RC CCHO RC CC(O)R1 RC CCO2R1 RC CCO2H RC CCOH RC CC2OH RC CH Leaders in Small Molecule Building Blocks

11. Alkyne Chemistry RC CC CR RC CC CR’ RC CCnX RC CCnC CCmX RC CH Leaders in Small Molecule Building Blocks

12. Alkyne Chemistry Indoles Benzofurans Isocoumarins RC CH Pyrimidines Isoquinolines Furopyridines Leaders in Small Molecule Building Blocks

13. Organometallics (Mg, Li, Na) R R’ Ar R (Ar) RC CR’ R(CH2)nOTHP RMgX RLi Leaders in Small Molecule Building Blocks

14. Organometallics (Mg, Li, Na) RCHO RCCOH Z E O R’ R’ CC CR RMgX RLi Leaders in Small Molecule Building Blocks

15. Halogen Chemistry (Cl, Br, I) RCC CCBr CH3 CH3 CCH2I CH3 I Br(CH2)Cl Cl, Br, I Leaders in Small Molecule Building Blocks

16. Heteroaromatic Chemistry Phenanthrolines Quinolines Bipyridines Terpyridines Pyrimidines Pyridines Phenylenediamines Acetylenes Leaders in Small Molecule Building Blocks

17. Acetylene Chemistry Halogenation Dehydrohalogenation Alkylation(NH3) Sonogashira Reactions Kumada Couplings Cadiot-Chodkiewicz Suzuki Coupling Trans Reductions(NH3) Diels-Alder Synthesis Ethynylation Barbier Reaction Skraup Synthesis Birch Reduction Heck Reaction Grignard/Alkyl Lithium Synthesis Finklestein Reaction Phase Transfer Core Organic Synthetic Methods Performed at GFS Leaders in Small Molecule Building Blocks

18. Acetylene Ammonia,liq. Alkyllithium Carbon disulfide Chloroformates Chlorosulfonic acid Epichlorohydrin Ethylene oxide Bromine Lithium amide Lithium metal Magnesium Sodium amide Sodium hydride Sodium metal Trialkylsilanes Iodine Hydrogen Chloride Reagents Handled Routinely at GFS in > 100 kg Quantities Leaders in Small Molecule Building Blocks